230 related articles for article (PubMed ID: 26283546)
21. Activation of mammalian terget of rapamycin kinase and glycogen synthase kinase-3β accompanies abnormal accumulation of cholesterol in fibroblasts from Niemann-Pick type C patients.
Wos M; Komiażyk M; Pikula S; Tylki-Szymanska A; Bandorowicz-Pikula J
J Cell Biochem; 2019 Apr; 120(4):6580-6588. PubMed ID: 30390318
[TBL] [Abstract][Full Text] [Related]
22. Sterol-modulated glycolipid sorting occurs in niemann-pick C1 late endosomes.
Zhang M; Dwyer NK; Neufeld EB; Love DC; Cooney A; Comly M; Patel S; Watari H; Strauss JF; Pentchev PG; Hanover JA; Blanchette-Mackie EJ
J Biol Chem; 2001 Feb; 276(5):3417-25. PubMed ID: 11032830
[TBL] [Abstract][Full Text] [Related]
23. Cholesterol trafficking is required for mTOR activation in endothelial cells.
Xu J; Dang Y; Ren YR; Liu JO
Proc Natl Acad Sci U S A; 2010 Mar; 107(10):4764-9. PubMed ID: 20176935
[TBL] [Abstract][Full Text] [Related]
24. Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts.
Hu Y; Carraro-Lacroix LR; Wang A; Owen C; Bajenova E; Corey PN; Brumell JH; Voronov I
J Cell Biochem; 2016 Feb; 117(2):413-25. PubMed ID: 26212375
[TBL] [Abstract][Full Text] [Related]
25. Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle.
Joassard OR; Amirouche A; Gallot YS; Desgeorges MM; Castells J; Durieux AC; Berthon P; Freyssenet DG
Int J Biochem Cell Biol; 2013 Nov; 45(11):2444-55. PubMed ID: 23916784
[TBL] [Abstract][Full Text] [Related]
26. Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons.
Trilck M; Peter F; Zheng C; Frank M; Dobrenis K; Mascher H; Rolfs A; Frech MJ
Brain Res; 2017 Feb; 1657():52-61. PubMed ID: 27923633
[TBL] [Abstract][Full Text] [Related]
27. The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts.
Garver WS; Jelinek D; Francis GA; Murphy BD
J Lipid Res; 2008 May; 49(5):1090-102. PubMed ID: 18272927
[TBL] [Abstract][Full Text] [Related]
28. ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation.
Parrales A; López E; Lee-Rivera I; López-Colomé AM
Cell Signal; 2013 Apr; 25(4):829-38. PubMed ID: 23291002
[TBL] [Abstract][Full Text] [Related]
29. mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy.
Zhao J; Zhai B; Gygi SP; Goldberg AL
Proc Natl Acad Sci U S A; 2015 Dec; 112(52):15790-7. PubMed ID: 26669439
[TBL] [Abstract][Full Text] [Related]
30. Fisetin regulates obesity by targeting mTORC1 signaling.
Jung CH; Kim H; Ahn J; Jeon TI; Lee DH; Ha TY
J Nutr Biochem; 2013 Aug; 24(8):1547-54. PubMed ID: 23517912
[TBL] [Abstract][Full Text] [Related]
31. Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking.
Lyu J; Yang EJ; Head SA; Ai N; Zhang B; Wu C; Li RJ; Liu Y; Chakravarty H; Zhang S; Tam KY; Dang Y; Kwon HJ; Ge W; Liu JO; Shim JS
Int J Biol Sci; 2018; 14(10):1175-1185. PubMed ID: 30123067
[TBL] [Abstract][Full Text] [Related]
32. A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele.
Praggastis M; Tortelli B; Zhang J; Fujiwara H; Sidhu R; Chacko A; Chen Z; Chung C; Lieberman AP; Sikora J; Davidson C; Walkley SU; Pipalia NH; Maxfield FR; Schaffer JE; Ory DS
J Neurosci; 2015 May; 35(21):8091-106. PubMed ID: 26019327
[TBL] [Abstract][Full Text] [Related]
33. Identification of lysosomal Npc1-binding proteins: Cathepsin D activity is regulated by NPC1.
Macías-Vidal J; Guerrero-Hernández M; Estanyol JM; Aguado C; Knecht E; Coll MJ; Bachs O
Proteomics; 2016 Jan; 16(1):150-8. PubMed ID: 26507101
[TBL] [Abstract][Full Text] [Related]
34. Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments.
Jelinek D; Patrick SM; Kitt KN; Chan T; Francis GA; Garver WS
J Cell Biochem; 2009 Dec; 108(5):1102-16. PubMed ID: 19746448
[TBL] [Abstract][Full Text] [Related]
35. NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Davis OB; Shin HR; Lim CY; Wu EY; Kukurugya M; Maher CF; Perera RM; Ordonez MP; Zoncu R
Dev Cell; 2021 Feb; 56(3):260-276.e7. PubMed ID: 33308480
[TBL] [Abstract][Full Text] [Related]
36. Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.
Pipalia NH; Cosner CC; Huang A; Chatterjee A; Bourbon P; Farley N; Helquist P; Wiest O; Maxfield FR
Proc Natl Acad Sci U S A; 2011 Apr; 108(14):5620-5. PubMed ID: 21436030
[TBL] [Abstract][Full Text] [Related]
37. HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts.
Pipalia NH; Saad SZ; Subramanian K; Cross A; Al-Motawa A; Garg K; Blagg BSJ; Neckers L; Helquist P; Wiest O; Ory DS; Maxfield FR
J Lipid Res; 2021; 62():100114. PubMed ID: 34481829
[TBL] [Abstract][Full Text] [Related]
38. A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.
Korkolopoulou P; Levidou G; Trigka EA; Prekete N; Karlou M; Thymara I; Sakellariou S; Fragkou P; Isaiadis D; Pavlopoulos P; Patsouris E; Saetta AA
BJU Int; 2012 Dec; 110(11 Pt C):E1237-48. PubMed ID: 23107319
[TBL] [Abstract][Full Text] [Related]
39. miR-218 inhibits the invasion and migration of colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway.
Zhang X; Shi H; Tang H; Fang Z; Wang J; Cui S
Int J Mol Med; 2015 May; 35(5):1301-8. PubMed ID: 25760926
[TBL] [Abstract][Full Text] [Related]
40. Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease.
Lloyd-Evans E; Platt FM
Traffic; 2010 Apr; 11(4):419-28. PubMed ID: 20059748
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]