These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Rational design of viscosity reducing mutants of a monoclonal antibody: hydrophobic versus electrostatic inter-molecular interactions. Nichols P; Li L; Kumar S; Buck PM; Singh SK; Goswami S; Balthazor B; Conley TR; Sek D; Allen MJ MAbs; 2015; 7(1):212-30. PubMed ID: 25559441 [TBL] [Abstract][Full Text] [Related]
5. Specific interactions in high concentration antibody solutions resulting in high viscosity. Yadav S; Liu J; Shire SJ; Kalonia DS J Pharm Sci; 2010 Mar; 99(3):1152-68. PubMed ID: 19705420 [TBL] [Abstract][Full Text] [Related]
6. Liquid-Liquid Phase Separation in a Dual Variable Domain Immunoglobulin Protein Solution: Effect of Formulation Factors and Protein-Protein Interactions. Raut AS; Kalonia DS Mol Pharm; 2015 Sep; 12(9):3261-71. PubMed ID: 26237070 [TBL] [Abstract][Full Text] [Related]
7. The Effect of Low Ionic Strength on Diffusion and Viscosity of Monoclonal Antibodies. Pindrus MA; Shire SJ; Yadav S; Kalonia DS Mol Pharm; 2018 Aug; 15(8):3133-3142. PubMed ID: 29996057 [TBL] [Abstract][Full Text] [Related]
8. Highly viscous antibody solutions are a consequence of network formation caused by domain-domain electrostatic complementarities: insights from coarse-grained simulations. Buck PM; Chaudhri A; Kumar S; Singh SK Mol Pharm; 2015 Jan; 12(1):127-39. PubMed ID: 25383990 [TBL] [Abstract][Full Text] [Related]
9. Application of high-frequency rheology measurements for analyzing protein-protein interactions in high protein concentration solutions using a model monoclonal antibody (IgG2). Saluja A; Badkar AV; Zeng DL; Nema S; Kalonia DS J Pharm Sci; 2006 Sep; 95(9):1967-83. PubMed ID: 16847932 [TBL] [Abstract][Full Text] [Related]
10. Intermolecular Interactions and the Viscosity of Highly Concentrated Monoclonal Antibody Solutions. Binabaji E; Ma J; Zydney AL Pharm Res; 2015 Sep; 32(9):3102-9. PubMed ID: 25832501 [TBL] [Abstract][Full Text] [Related]
11. Impact of short range hydrophobic interactions and long range electrostatic forces on the aggregation kinetics of a monoclonal antibody and a dual-variable domain immunoglobulin at low and high concentrations. Kumar V; Dixit N; Zhou LL; Fraunhofer W Int J Pharm; 2011 Dec; 421(1):82-93. PubMed ID: 21959107 [TBL] [Abstract][Full Text] [Related]
12. Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution. Liu J; Nguyen MD; Andya JD; Shire SJ J Pharm Sci; 2005 Sep; 94(9):1928-40. PubMed ID: 16052543 [TBL] [Abstract][Full Text] [Related]
13. Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation. Salinas BA; Sathish HA; Bishop SM; Harn N; Carpenter JF; Randolph TW J Pharm Sci; 2010 Jan; 99(1):82-93. PubMed ID: 19475558 [TBL] [Abstract][Full Text] [Related]
14. Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass - prediction of viscosity through protein-protein interaction measurements. Neergaard MS; Kalonia DS; Parshad H; Nielsen AD; Møller EH; van de Weert M Eur J Pharm Sci; 2013 Jun; 49(3):400-10. PubMed ID: 23624326 [TBL] [Abstract][Full Text] [Related]
15. How Well Do Low- and High-Concentration Protein Interactions Predict Solution Viscosities of Monoclonal Antibodies? Woldeyes MA; Qi W; Razinkov VI; Furst EM; Roberts CJ J Pharm Sci; 2019 Jan; 108(1):142-154. PubMed ID: 30017887 [TBL] [Abstract][Full Text] [Related]
16. Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure. Chow CK; Allan BW; Chai Q; Atwell S; Lu J Mol Pharm; 2016 Mar; 13(3):915-23. PubMed ID: 26849155 [TBL] [Abstract][Full Text] [Related]
17. Characterization of the NISTmAb Reference Material using small-angle scattering and molecular simulation : Part II: Concentrated protein solutions. Castellanos MM; Mattison K; Krueger S; Curtis JE Anal Bioanal Chem; 2018 Mar; 410(8):2161-2171. PubMed ID: 29423596 [TBL] [Abstract][Full Text] [Related]