These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
95 related articles for article (PubMed ID: 26294260)
1. Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor. Rioux N; Duncan KW; Lantz RJ; Miao X; Chan-Penebre E; Moyer MP; Munchhof MJ; Copeland RA; Chesworth R; Waters NJ Xenobiotica; 2016; 46(3):268-77. PubMed ID: 26294260 [TBL] [Abstract][Full Text] [Related]
2. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. Niwa T; Shiraga T; Mitani Y; Terakawa M; Tokuma Y; Kagayama A Drug Metab Dispos; 2000 Sep; 28(9):1128-34. PubMed ID: 10950860 [TBL] [Abstract][Full Text] [Related]
3. Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL. Kamath AV; Wang J; Lee FY; Marathe PH Cancer Chemother Pharmacol; 2008 Mar; 61(3):365-76. PubMed ID: 17429625 [TBL] [Abstract][Full Text] [Related]
4. Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652. Rioux N; Mitchell LH; Tiller P; Plant K; Shaw J; Frost K; Ribich S; Moyer MP; Copeland RA; Chesworth R; Waters NJ Drug Metab Dispos; 2015 Jul; 43(7):936-43. PubMed ID: 25887455 [TBL] [Abstract][Full Text] [Related]
5. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes. Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915 [TBL] [Abstract][Full Text] [Related]
6. EPZ015666, a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an antitumour effect in retinoblastoma. Liu X; He J; Mao L; Zhang Y; Cui W; Duan S; Jiang A; Gao Y; Sang Y; Huang G Exp Eye Res; 2021 Jan; 202():108286. PubMed ID: 33035554 [TBL] [Abstract][Full Text] [Related]
7. Metabolism and Disposition of Pacritinib (SB1518), an Orally Active Janus Kinase 2 Inhibitor in Preclinical Species and Humans. Jayaraman R; Pasha MK; Williams A; Goh KC; Ethirajulu K Drug Metab Lett; 2015; 9(1):28-47. PubMed ID: 25600203 [TBL] [Abstract][Full Text] [Related]
8. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Chan-Penebre E; Kuplast KG; Majer CR; Boriack-Sjodin PA; Wigle TJ; Johnston LD; Rioux N; Munchhof MJ; Jin L; Jacques SL; West KA; Lingaraj T; Stickland K; Ribich SA; Raimondi A; Scott MP; Waters NJ; Pollock RM; Smith JJ; Barbash O; Pappalardi M; Ho TF; Nurse K; Oza KP; Gallagher KT; Kruger R; Moyer MP; Copeland RA; Chesworth R; Duncan KW Nat Chem Biol; 2015 Jun; 11(6):432-7. PubMed ID: 25915199 [TBL] [Abstract][Full Text] [Related]
9. Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human. Sharma R; Sun H; Piotrowski DW; Ryder TF; Doran SD; Dai H; Prakash C Drug Metab Dispos; 2012 Nov; 40(11):2143-61. PubMed ID: 22896728 [TBL] [Abstract][Full Text] [Related]
10. In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human. Erickson DA; Hollfelder S; Tenge J; Gohdes M; Burkhardt JJ; Krieter PA Drug Metab Dispos; 2007 Dec; 35(12):2232-41. PubMed ID: 17881661 [TBL] [Abstract][Full Text] [Related]
11. Metabolism of aildenafil in vivo in rats and in vitro in mouse, rat, dog, and human liver microsomes. Li Y; Wu L; Gu Y; Si D; Liu C Drug Test Anal; 2014 Jun; 6(6):552-62. PubMed ID: 24311535 [TBL] [Abstract][Full Text] [Related]
12. Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data. Walker DK; Alabaster CT; Congrave GS; Hargreaves MB; Hyland R; Jones BC; Reed LJ; Smith DA Drug Metab Dispos; 1996 Apr; 24(4):447-55. PubMed ID: 8801060 [TBL] [Abstract][Full Text] [Related]
13. Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation. Obach RS Drug Metab Dispos; 2000 Sep; 28(9):1069-76. PubMed ID: 10950851 [TBL] [Abstract][Full Text] [Related]
14. Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans. Reid JM; Kuffel MJ; Ruben SL; Morales JJ; Rinehart KL; Squillace DP; Ames MM Clin Cancer Res; 2002 Sep; 8(9):2952-62. PubMed ID: 12231541 [TBL] [Abstract][Full Text] [Related]
15. Metabolism of dictamnine in liver microsomes from mouse, rat, dog, monkey, and human. Wang P; Zhao Y; Zhu Y; Sun J; Yerke A; Sang S; Yu Z J Pharm Biomed Anal; 2016 Feb; 119():166-74. PubMed ID: 26683990 [TBL] [Abstract][Full Text] [Related]
16. Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor. Liu L; Halladay JS; Shin Y; Wong S; Coraggio M; La H; Baumgardner M; Le H; Gopaul S; Boggs J; Kuebler P; Davis JC; Liao XC; Lubach JW; Deese A; Sowell CG; Currie KS; Young WB; Khojasteh SC; Hop CE; Wong H Drug Metab Dispos; 2011 Oct; 39(10):1840-9. PubMed ID: 21742900 [TBL] [Abstract][Full Text] [Related]
17. Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. Wong H; Chen JZ; Chou B; Halladay JS; Kenny JR; La H; Marsters JC; Plise E; Rudewicz PJ; Robarge K; Shin Y; Wong S; Zhang C; Khojasteh SC Xenobiotica; 2009 Nov; 39(11):850-61. PubMed ID: 19845436 [TBL] [Abstract][Full Text] [Related]
18. In vitro metabolism of tirilazad mesylate in male and female rats. Contribution of cytochrome P4502C11 and delta 4-5 alpha-reductase. Wienkers LC; Steenwyk RC; Mizsak SA; Pearson PG Drug Metab Dispos; 1995 Mar; 23(3):383-92. PubMed ID: 7628305 [TBL] [Abstract][Full Text] [Related]
19. Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor. Lin JH; Chiba M; Balani SK; Chen IW; Kwei GY; Vastag KJ; Nishime JA Drug Metab Dispos; 1996 Oct; 24(10):1111-20. PubMed ID: 8894513 [TBL] [Abstract][Full Text] [Related]
20. Comparative metabolism of cinobufagin in liver microsomes from mouse, rat, dog, minipig, monkey, and human. Ma XC; Ning J; Ge GB; Liang SC; Wang XL; Zhang BJ; Huang SS; Li JK; Yang L Drug Metab Dispos; 2011 Apr; 39(4):675-82. PubMed ID: 21205911 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]