167 related articles for article (PubMed ID: 26299827)
1. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands.
Deekonda S; Wugalter L; Kulkarni V; Rankin D; Largent-Milnes TM; Davis P; Bassirirad NM; Lai J; Vanderah TW; Porreca F; Hruby VJ
Bioorg Med Chem; 2015 Sep; 23(18):6185-94. PubMed ID: 26299827
[TBL] [Abstract][Full Text] [Related]
2. Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands.
Deekonda S; Rankin D; Davis P; Lai J; Vanderah TW; Porecca F; Hruby VJ
Bioorg Med Chem; 2016 Jan; 24(2):85-91. PubMed ID: 26712115
[TBL] [Abstract][Full Text] [Related]
3. Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations.
Deekonda S; Cole J; Sunna S; Rankin D; Largent-Milnes TM; Davis P; BassiriRad NM; Lai J; Vanderah TW; Porecca F; Hruby VJ
Bioorg Med Chem Lett; 2016 Jan; 26(1):222-7. PubMed ID: 26611918
[TBL] [Abstract][Full Text] [Related]
4. Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Ananthan S; Johnson CA; Carter RL; Clayton SD; Rice KC; Xu H; Davis P; Porreca F; Rothman RB
J Med Chem; 1998 Jul; 41(15):2872-81. PubMed ID: 9667975
[TBL] [Abstract][Full Text] [Related]
5. Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays.
Bonner GG; Davis P; Stropova D; Edsall S; Yamamura HI; Porreca F; Hruby VJ
J Med Chem; 2000 Feb; 43(4):569-80. PubMed ID: 10691683
[TBL] [Abstract][Full Text] [Related]
6. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.
Deekonda S; Wugalter L; Rankin D; Largent-Milnes TM; Davis P; Wang Y; Bassirirad NM; Lai J; Kulkarni V; Vanderah TW; Porreca F; Hruby VJ
Bioorg Med Chem Lett; 2015 Oct; 25(20):4683-8. PubMed ID: 26323872
[TBL] [Abstract][Full Text] [Related]
7. Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors.
Zaveri NT; Journigan VB; Polgar WE
ACS Chem Neurosci; 2015 Apr; 6(4):646-57. PubMed ID: 25635572
[TBL] [Abstract][Full Text] [Related]
8. Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans.
Ananthan S; Khare NK; Saini SK; Davis P; Dersch CM; Porreca F; Rothman RB
Bioorg Med Chem; 2003 Sep; 11(18):4143-54. PubMed ID: 12927876
[TBL] [Abstract][Full Text] [Related]
9. Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
Lee YS; Petrov R; Park CK; Ma SW; Davis P; Lai J; Porreca F; Vardanyan R; Hruby VJ
J Med Chem; 2007 Nov; 50(22):5528-32. PubMed ID: 17927164
[TBL] [Abstract][Full Text] [Related]
10. Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.
McLamore S; Ullrich T; Rothman RB; Xu H; Dersch C; Coop A; Davis P; Porreca F; Jacobson AE; Rice KC
J Med Chem; 2001 Apr; 44(9):1471-4. PubMed ID: 11311071
[TBL] [Abstract][Full Text] [Related]
11. Evaluation of N-substituent structural variations in opioid receptor profile of LP1.
Pasquinucci L; Turnaturi R; Aricò G; Parenti C; Pallaki P; Georgoussi Z; Ronsisvalle S
Bioorg Med Chem; 2016 Jun; 24(12):2832-42. PubMed ID: 27234885
[TBL] [Abstract][Full Text] [Related]
12. Development of potent μ and δ opioid agonists with high lipophilicity.
Lee YS; Kulkarani V; Cowell SM; Ma SW; Davis P; Hanlon KE; Vanderah TW; Lai J; Porreca F; Vardanyan R; Hruby VJ
J Med Chem; 2011 Jan; 54(1):382-6. PubMed ID: 21128594
[TBL] [Abstract][Full Text] [Related]
13. Propionamide Derivatives as Dual μ-Opioid Receptor Agonists and σ
García M; Llorente V; Garriga L; Christmann U; Rodríguez-Escrich S; Virgili M; Fernández B; Bordas M; Ayet E; Burgueño J; Pujol M; Dordal A; Portillo-Salido E; Gris G; Vela JM; Almansa C
J Med Chem; 2021 Jul; 64(14):10139-10154. PubMed ID: 34236190
[TBL] [Abstract][Full Text] [Related]
14. Piperidine propionamide as a scaffold for potent sigma-1 receptor antagonists and mu opioid receptor agonists for treating neuropathic pain.
Xiong J; Jin J; Gao L; Hao C; Liu X; Liu BF; Chen Y; Zhang G
Eur J Med Chem; 2020 Apr; 191():112144. PubMed ID: 32087465
[TBL] [Abstract][Full Text] [Related]
15. Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities.
Healy JR; Bezawada P; Shim J; Jones JW; Kane MA; MacKerell AD; Coop A; Matsumoto RR
ACS Chem Neurosci; 2013 Sep; 4(9):1256-66. PubMed ID: 23713721
[TBL] [Abstract][Full Text] [Related]
16. Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships.
Journigan VB; Polgar WE; Tuan EW; Lu J; Daga PR; Zaveri NT
Sci Rep; 2017 Oct; 7(1):13255. PubMed ID: 29038479
[TBL] [Abstract][Full Text] [Related]
17. Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.
Lee YS; Nyberg J; Moye S; Agnes RS; Davis P; Ma SW; Lai J; Porreca F; Vardanyan R; Hruby VJ
Bioorg Med Chem Lett; 2007 Apr; 17(8):2161-5. PubMed ID: 17329100
[TBL] [Abstract][Full Text] [Related]
18. Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Salvadori S; Balboni G; Guerrini R; Tomatis R; Bianchi C; Bryant SD; Cooper PS; Lazarus LH
J Med Chem; 1997 Sep; 40(19):3100-8. PubMed ID: 9301674
[TBL] [Abstract][Full Text] [Related]
19. Structure-activity relationships of dermorphin analogues containing N-substituted amino acids in the 2-position of the peptide sequence.
Schmidt R; Kálmán A; Chung NN; Lemieux C; Horváth C; Schiller PW
Int J Pept Protein Res; 1995 Jul; 46(1):47-55. PubMed ID: 7558596
[TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies.
Watanabe Y; Kitazawa S; Nemoto T; Hirayama S; Iwai T; Fujii H; Nagase H
Bioorg Med Chem; 2013 Jun; 21(11):3032-50. PubMed ID: 23623711
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]