BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

121 related articles for article (PubMed ID: 26307943)

  • 1. Design, characterization and cellular uptake studies of fluorescence-labeled prototypic cathepsin inhibitors.
    Kohl F; Schmitz J; Furtmann N; Schulz-Fincke AC; Mertens MD; Küppers J; Benkhoff M; Tobiasch E; Bartz U; Bajorath J; Stirnberg M; Gütschow M
    Org Biomol Chem; 2015 Nov; 13(41):10310-23. PubMed ID: 26307943
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fluorescent nitrile-based inhibitors of cysteine cathepsins.
    Frizler M; Mertens MD; Gütschow M
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7715-8. PubMed ID: 23122525
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl.
    Alper PB; Liu H; Chatterjee AK; Nguyen KT; Tully DC; Tumanut C; Li J; Harris JL; Tuntland T; Chang J; Gordon P; Hollenbeck T; Karanewsky DS
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1486-90. PubMed ID: 16412634
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The consequences of lysosomotropism on the design of selective cathepsin K inhibitors.
    Black WC; Percival MD
    Chembiochem; 2006 Oct; 7(10):1525-35. PubMed ID: 16921579
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors.
    Yadav MR; Shinde AK; Chouhan BS; Giridhar R; Menard R
    J Enzyme Inhib Med Chem; 2008 Apr; 23(2):190-7. PubMed ID: 18343903
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic.
    Thompson SK; Smith WW; Zhao B; Halbert SM; Tomaszek TA; Tew DG; Levy MA; Janson CA; DAlessio KJ; McQueney MS; Kurdyla J; Jones CS; DesJarlais RL; Abdel-Meguid SS; Veber DF
    J Med Chem; 1998 Oct; 41(21):3923-7. PubMed ID: 9767629
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K.
    Marquis RW; Yamashita DS; Ru Y; LoCastro SM; Oh HJ; Erhard KF; DesJarlais RL; Head MS; Smith WW; Zhao B; Janson CA; Abdel-Meguid SS; Tomaszek TA; Levy MA; Veber DF
    J Med Chem; 1998 Sep; 41(19):3563-7. PubMed ID: 9733481
    [No Abstract]   [Full Text] [Related]  

  • 8. Discovery of selective and nonpeptidic cathepsin S inhibitors.
    Irie O; Ehara T; Iwasaki A; Yokokawa F; Sakaki J; Hirao H; Kanazawa T; Teno N; Horiuchi M; Umemura I; Gunji H; Masuya K; Hitomi Y; Iwasaki G; Nonomura K; Tanabe K; Fukaya H; Kosaka T; Snell CR; Hallett A
    Bioorg Med Chem Lett; 2008 Jul; 18(14):3959-62. PubMed ID: 18572405
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Active Site Mapping of Human Cathepsin F with Dipeptide Nitrile Inhibitors.
    Schmitz J; Furtmann N; Ponert M; Frizler M; Löser R; Bartz U; Bajorath J; Gütschow M
    ChemMedChem; 2015 Aug; 10(8):1365-77. PubMed ID: 26119278
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Highly selective azadipeptide nitrile inhibitors for cathepsin K: design, synthesis and activity assays.
    Ren XF; Li HW; Fang X; Wu Y; Wang L; Zou S
    Org Biomol Chem; 2013 Feb; 11(7):1143-8. PubMed ID: 23299878
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K.
    Duffy KJ; Ridgers LH; DesJarlais RL; Tomaszek TA; Bossard MJ; Thompson SK; Keenan RM; Veber DF
    Bioorg Med Chem Lett; 1999 Jul; 9(14):1907-10. PubMed ID: 10450951
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dipeptide-derived nitriles containing additional electrophilic sites: potentially irreversible inhibitors of cysteine proteases.
    Löser R; Gütschow M
    J Enzyme Inhib Med Chem; 2009 Dec; 24(6):1245-52. PubMed ID: 19912058
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design.
    Ménard R; Therrien C; Lachance P; Sulea T; Qo H; Alvarez-Hernandez AD; Roush WR
    Biol Chem; 2001 May; 382(5):839-45. PubMed ID: 11517939
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation.
    Caglič D; Globisch A; Kindermann M; Lim NH; Jeske V; Juretschke HP; Bartnik E; Weithmann KU; Nagase H; Turk B; Wendt KU
    Bioorg Med Chem; 2011 Feb; 19(3):1055-61. PubMed ID: 21130662
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity.
    Setti EL; Davis D; Janc JW; Jeffery DA; Cheung H; Yu W
    Bioorg Med Chem Lett; 2005 Mar; 15(5):1529-34. PubMed ID: 15713422
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design of potent, selective, and orally bioavailable inhibitors of cysteine protease cathepsin k.
    Tavares FX; Boncek V; Deaton DN; Hassell AM; Long ST; Miller AB; Payne AA; Miller LR; Shewchuk LM; Wells-Knecht K; Willard DH; Wright LL; Zhou HQ
    J Med Chem; 2004 Jan; 47(3):588-99. PubMed ID: 14736240
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of cell-active non-peptidyl inhibitors of cysteine cathepsins.
    Dana D; Davalos AR; De S; Rathod P; Gamage RK; Huestis J; Afzal N; Zavlanov Y; Paroly SS; Rotenberg SA; Subramaniam G; Mark KJ; Chang EJ; Kumar S
    Bioorg Med Chem; 2013 Jun; 21(11):2975-87. PubMed ID: 23623677
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.
    Myers MC; Shah PP; Beavers MP; Napper AD; Diamond SL; Smith AB; Huryn DM
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3646-51. PubMed ID: 18499453
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis.
    Robichaud J; Black WC; Thérien M; Paquet J; Oballa RM; Bayly CI; McKay DJ; Wang Q; Isabel E; Léger S; Mellon C; Kimmel DB; Wesolowski G; Percival MD; Massé F; Desmarais S; Falgueyret JP; Crane SN
    J Med Chem; 2008 Oct; 51(20):6410-20. PubMed ID: 18811135
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Benzodioxocin-3-ones and N-acyl-3-amino-3-buten-2-ones: novel classes of cathepsin K cysteine protease inhibitors.
    Yamashita DS; Xie R; Lin H; Wang B; Shi SD; Quinn CJ; Hemling ME; Hissong C; Tomaszek TA; Veber DF
    J Pept Res; 2004 Mar; 63(3):265-9. PubMed ID: 15049838
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.