118 related articles for article (PubMed ID: 26314925)
1. Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors.
Li YL; Qi XY; Jiang H; Deng XD; Dong YP; Ding TB; Zhou L; Men P; Chu Y; Wang RX; Jiang XC; Ye DY
Bioorg Med Chem; 2015 Sep; 23(18):6173-84. PubMed ID: 26314925
[TBL] [Abstract][Full Text] [Related]
2. Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine.
Qi XY; Cao Y; Li YL; Mo MG; Zhou L; Ye DY
Bioorg Med Chem Lett; 2017 Aug; 27(15):3511-3515. PubMed ID: 28619536
[TBL] [Abstract][Full Text] [Related]
3. Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors.
Adachi R; Ogawa K; Matsumoto SI; Satou T; Tanaka Y; Sakamoto J; Nakahata T; Okamoto R; Kamaura M; Kawamoto T
Eur J Med Chem; 2017 Aug; 136():283-293. PubMed ID: 28505533
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.
Li Z; Hailemariam TK; Zhou H; Li Y; Duckworth DC; Peake DA; Zhang Y; Kuo MS; Cao G; Jiang XC
Biochim Biophys Acta; 2007 Sep; 1771(9):1186-94. PubMed ID: 17616479
[TBL] [Abstract][Full Text] [Related]
5. Identification of small molecule sphingomyelin synthase inhibitors.
Deng X; Lin F; Zhang Y; Li Y; Zhou L; Lou B; Li Y; Dong J; Ding T; Jiang X; Wang R; Ye D
Eur J Med Chem; 2014 Feb; 73():1-7. PubMed ID: 24374347
[TBL] [Abstract][Full Text] [Related]
6. Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death.
Lafont E; Milhas D; Carpentier S; Garcia V; Jin ZX; Umehara H; Okazaki T; Schulze-Osthoff K; Levade T; Benoist H; Ségui B
Cell Death Differ; 2010 Apr; 17(4):642-54. PubMed ID: 19779494
[TBL] [Abstract][Full Text] [Related]
7. Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
Wu M; Takemoto M; Taniguchi M; Takumi T; Okazaki T; Song WJ
Am J Physiol Cell Physiol; 2016 Jul; 311(1):C15-23. PubMed ID: 27194473
[TBL] [Abstract][Full Text] [Related]
8. Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage.
Separovic D; Semaan L; Tarca AL; Awad Maitah MY; Hanada K; Bielawski J; Villani M; Luberto C
Exp Cell Res; 2008 May; 314(8):1860-8. PubMed ID: 18374917
[TBL] [Abstract][Full Text] [Related]
9. Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometry.
Chen Y; Yurek DA; Yu L; Wang H; Ehsani ME; Qian YW; Konrad RJ; Jiang XC; Kuo MS; Cao G; Wang J
Anal Biochem; 2013 Jul; 438(1):61-6. PubMed ID: 23535273
[TBL] [Abstract][Full Text] [Related]
10. Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes.
Tani M; Kuge O
Biochem Biophys Res Commun; 2009 Apr; 381(3):328-32. PubMed ID: 19233134
[TBL] [Abstract][Full Text] [Related]
11. The domain responsible for sphingomyelin synthase (SMS) activity.
Yeang C; Varshney S; Wang R; Zhang Y; Ye D; Jiang XC
Biochim Biophys Acta; 2008 Oct; 1781(10):610-7. PubMed ID: 18694848
[TBL] [Abstract][Full Text] [Related]
12. Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels.
Hayashi Y; Nemoto-Sasaki Y; Matsumoto N; Hama K; Tanikawa T; Oka S; Saeki T; Kumasaka T; Koizumi T; Arai S; Wada I; Yokoyama K; Sugiura T; Yamashita A
J Biol Chem; 2018 Nov; 293(45):17505-17522. PubMed ID: 30242129
[TBL] [Abstract][Full Text] [Related]
13. Comparative analysis of sphingomyelin synthase 1 gene expression at the transcriptional and translational levels in human tissues.
Sudarkina OY; Filippenkov IB; Brodsky IB; Limborska SA; Dergunova LV
Mol Cell Biochem; 2015 Aug; 406(1-2):91-9. PubMed ID: 25912551
[TBL] [Abstract][Full Text] [Related]
14. SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis.
Ding T; Li Z; Hailemariam T; Mukherjee S; Maxfield FR; Wu MP; Jiang XC
J Lipid Res; 2008 Feb; 49(2):376-85. PubMed ID: 17982138
[TBL] [Abstract][Full Text] [Related]
15. Novel Interconnections in Lipid Metabolism Revealed by Overexpression of Sphingomyelin Synthase-1.
Deevska GM; Dotson PP; Karakashian AA; Isaac G; Wrona M; Kelly SB; Merrill AH; Nikolova-Karakashian MN
J Biol Chem; 2017 Mar; 292(12):5110-5122. PubMed ID: 28087695
[TBL] [Abstract][Full Text] [Related]
16. Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells.
Jin ZX; Huang CR; Dong L; Goda S; Kawanami T; Sawaki T; Sakai T; Tong XP; Masaki Y; Fukushima T; Tanaka M; Mimori T; Tojo H; Bloom ET; Okazaki T; Umehara H
Int Immunol; 2008 Nov; 20(11):1427-37. PubMed ID: 18820264
[TBL] [Abstract][Full Text] [Related]
17. Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells.
Tafesse FG; Huitema K; Hermansson M; van der Poel S; van den Dikkenberg J; Uphoff A; Somerharju P; Holthuis JC
J Biol Chem; 2007 Jun; 282(24):17537-47. PubMed ID: 17449912
[TBL] [Abstract][Full Text] [Related]
18. Human sphingomyelin synthase 1 gene (SMS1): organization, multiple mRNA splice variants and expression in adult tissues.
Rozhkova AV; Dmitrieva VG; Zhapparova ON; Sudarkina OY; Nadezhdina ES; Limborska SA; Dergunova LV
Gene; 2011 Aug; 481(2):65-75. PubMed ID: 21549185
[TBL] [Abstract][Full Text] [Related]
19. Discovery of 2-((3-cyanopyridin-2-yl)thio)acetamides as human lactate dehydrogenase A inhibitors to reduce the growth of MG-63 osteosarcoma cells: Virtual screening and biological validation.
Cui W; Lv W; Qu Y; Ma R; Wang YW; Xu YJ; Wu D; Chen X
Bioorg Med Chem Lett; 2016 Aug; 26(16):3984-7. PubMed ID: 27406795
[TBL] [Abstract][Full Text] [Related]
20. Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice.
Mo M; Yang J; Jiang XC; Cao Y; Fei J; Chen Y; Qi X; Chu Y; Zhou L; Ye D
J Med Chem; 2018 Sep; 61(18):8241-8254. PubMed ID: 30074791
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]