BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

182 related articles for article (PubMed ID: 26322631)

  • 1. Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
    Eadsforth TC; Pinto A; Luciani R; Tamborini L; Cullia G; De Micheli C; Marinelli L; Cosconati S; Novellino E; Lo Presti L; Cordeiro da Silva A; Conti P; Hunter WN; Costi MP
    J Med Chem; 2015 Oct; 58(20):7938-48. PubMed ID: 26322631
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.
    Spinks D; Torrie LS; Thompson S; Harrison JR; Frearson JA; Read KD; Fairlamb AH; Wyatt PG; Gilbert IH
    ChemMedChem; 2012 Jan; 7(1):95-106. PubMed ID: 22162199
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro.
    Ferrigno F; Biancofiore I; Malancona S; Ponzi S; Paonessa G; Graziani R; Bresciani A; Gennari N; Di Marco A; Kaiser M; Summa V; Harper S; Ontoria JM
    Bioorg Med Chem Lett; 2018 Dec; 28(23-24):3689-3692. PubMed ID: 30482621
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
    Bayliss T; Robinson DA; Smith VC; Brand S; McElroy SP; Torrie LS; Mpamhanga C; Norval S; Stojanovski L; Brenk R; Frearson JA; Read KD; Gilbert IH; Wyatt PG
    J Med Chem; 2017 Dec; 60(23):9790-9806. PubMed ID: 29125744
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.
    Maiwald F; Benítez D; Charquero D; Dar MA; Erdmann H; Preu L; Koch O; Hölscher C; Loaëc N; Meijer L; Comini MA; Kunick C
    Eur J Med Chem; 2014 Aug; 83():274-83. PubMed ID: 24973661
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.
    Bressi JC; Choe J; Hough MT; Buckner FS; Van Voorhis WC; Verlinde CL; Hol WG; Gelb MH
    J Med Chem; 2000 Nov; 43(22):4135-50. PubMed ID: 11063610
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates.
    Yang G; Zhu W; Kim K; Byun SY; Choi G; Wang K; Cha JS; Cho HS; Oldfield E; No JH
    Antimicrob Agents Chemother; 2015 Dec; 59(12):7530-9. PubMed ID: 26392508
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents.
    Ding D; Meng Q; Gao G; Zhao Y; Wang Q; Nare B; Jacobs R; Rock F; Alley MR; Plattner JJ; Chen G; Li D; Zhou H
    J Med Chem; 2011 Mar; 54(5):1276-87. PubMed ID: 21322634
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
    Huang W; Zhang Z; Barros-Álvarez X; Koh CY; Ranade RM; Gillespie JR; Creason SA; Shibata S; Verlinde CLMJ; Hol WGJ; Buckner FS; Fan E
    Eur J Med Chem; 2016 Nov; 124():1081-1092. PubMed ID: 27788467
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei.
    Wu P; Zhang J; Meng Q; Nare B; Jacobs RT; Zhou H
    Eur J Med Chem; 2014 Jun; 81():59-75. PubMed ID: 24826816
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
    Lepesheva GI; Park HW; Hargrove TY; Vanhollebeke B; Wawrzak Z; Harp JM; Sundaramoorthy M; Nes WD; Pays E; Chaudhuri M; Villalta F; Waterman MR
    J Biol Chem; 2010 Jan; 285(3):1773-80. PubMed ID: 19923211
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors.
    Xin W; Li Z; Wang Q; Du J; Zhu M; Zhou H
    Eur J Med Chem; 2020 Jan; 185():111827. PubMed ID: 31732256
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi.
    Belluti F; Uliassi E; Veronesi G; Bergamini C; Kaiser M; Brun R; Viola A; Fato R; Michels PA; Krauth-Siegel RL; Cavalli A; Bolognesi ML
    ChemMedChem; 2014 Feb; 9(2):371-82. PubMed ID: 24403089
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis.
    Dardonville C; Rinaldi E; Hanau S; Barrett MP; Brun R; Gilbert IH
    Bioorg Med Chem; 2003 Jul; 11(14):3205-14. PubMed ID: 12818683
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor.
    Valenciano AL; Ramsey AC; Santos WL; Mackey ZB
    Bioorg Med Chem; 2016 Oct; 24(19):4647-4651. PubMed ID: 27519462
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.
    Aronov AM; Verlinde CL; Hol WG; Gelb MH
    J Med Chem; 1998 Nov; 41(24):4790-9. PubMed ID: 9822549
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei.
    Pham T; Walden M; Butler C; Diaz-Gonzalez R; Pérez-Moreno G; Ceballos-Pérez G; Gomez-Pérez V; García-Hernández R; Zecca H; Krakoff E; Kopec B; Ichire O; Mackenzie C; Pitot M; Ruiz LM; Gamarro F; González-Pacanowska D; Navarro M; Dounay AB
    Bioorg Med Chem Lett; 2017 Aug; 27(16):3629-3635. PubMed ID: 28729055
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.
    Tatipaka HB; Gillespie JR; Chatterjee AK; Norcross NR; Hulverson MA; Ranade RM; Nagendar P; Creason SA; McQueen J; Duster NA; Nagle A; Supek F; Molteni V; Wenzler T; Brun R; Glynne R; Buckner FS; Gelb MH
    J Med Chem; 2014 Feb; 57(3):828-35. PubMed ID: 24354316
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT.
    Ciammaichella A; Ferrigno F; Basta A; D'Amico M; Biancofiore I; Nardi V; Ponzi S; Graziani R; Gennari N; Vittoria Orsale M; Fini I; Paonessa G; Summa V; Harper S; Ontoria JM
    Bioorg Med Chem Lett; 2020 Jun; 30(12):127207. PubMed ID: 32354566
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.
    Ferrins L; Rahmani R; Sykes ML; Jones AJ; Avery VM; Teston E; Almohaywi B; Yin J; Smith J; Hyland C; White KL; Ryan E; Campbell M; Charman SA; Kaiser M; Baell JB
    Eur J Med Chem; 2013 Aug; 66():450-65. PubMed ID: 23831695
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.