BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

347 related articles for article (PubMed ID: 26334499)

  • 41. Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison.
    Kunwar S; Hwang SY; Katila P; Park S; Jeon KH; Kim D; Kadayat TM; Kwon Y; Lee ES
    Eur J Med Chem; 2021 Dec; 226():113860. PubMed ID: 34597897
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors.
    Cheng P; Zhu L; Guo W; Liu W; Yao J; Dong G; Zhang Y; Zhuang C; Sheng C; Miao Z; Zhang W
    J Enzyme Inhib Med Chem; 2012 Jun; 27(3):437-42. PubMed ID: 21770860
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors.
    Ibrahim MK; Taghour MS; Metwaly AM; Belal A; Mehany ABM; Elhendawy MA; Radwan MM; Yassin AM; El-Deeb NM; Hafez EE; ElSohly MA; Eissa IH
    Eur J Med Chem; 2018 Jul; 155():117-134. PubMed ID: 29885574
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Synthesis, Biological Evaluation and Molecular Docking Study of Cyclic Diarylheptanoids as Potential Anticancer Therapeutics.
    Lu Y; Yin W; Alam MS; Kadi AA; Jahng Y; Kwon Y; Rahman AFMM
    Anticancer Agents Med Chem; 2020; 20(4):464-475. PubMed ID: 31763968
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors.
    El-Adl K; El-Helby AA; Sakr H; Elwan A
    Bioorg Chem; 2020 Dec; 105():104399. PubMed ID: 33113414
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents.
    Thapa P; Jun KY; Kadayat TM; Park C; Zheng Z; Thapa Magar TB; Bist G; Shrestha A; Na Y; Kwon Y; Lee ES
    Bioorg Med Chem; 2015 Oct; 23(19):6454-66. PubMed ID: 26361737
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones.
    Ahn G; Schifano-Faux N; Goossens JF; Baldeyrou B; Couture A; Grandclaudon P; Lansiaux A; Ryckebusch A
    Bioorg Med Chem Lett; 2011 Apr; 21(8):2259-63. PubMed ID: 21439821
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Design, synthesis, biological evaluation, structure-activity relationship study, and mode of action of 2-phenol-4,6-dichlorophenyl-pyridines.
    Shrestha A; Park S; Shin S; Man Kadayat T; Bist G; Katila P; Kwon Y; Lee ES
    Bioorg Chem; 2018 Sep; 79():1-18. PubMed ID: 29715635
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Design, synthesis and biological evaluation of lapachol derivatives possessing indole scaffolds as topoisomerase I inhibitors.
    Zhang C; Qu Y; Niu B
    Bioorg Med Chem; 2016 Nov; 24(22):5781-5786. PubMed ID: 27667553
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Design, synthesis, cytotoxicity, HuTopoIIα inhibitory activity and molecular docking studies of pyrazole derivatives as potential anticancer agents.
    Alam R; Wahi D; Singh R; Sinha D; Tandon V; Grover A; Rahisuddin
    Bioorg Chem; 2016 Dec; 69():77-90. PubMed ID: 27744115
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Synthesis of aryl-substituted naphthalenoids as potent topoisomerase inhibitors.
    Shen Y; Chen W; Li Z; Shen Y
    Med Chem; 2014; 10(5):533-9. PubMed ID: 24047216
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships.
    Kunwar S; Hwang SY; Katila P; Man Kadayat T; Jung AR; Kwon Y; Lee ES
    Bioorg Med Chem Lett; 2022 Mar; 60():128606. PubMed ID: 35123005
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Inhibition of human topoisomerase I and II and anti-proliferative effects on MCF-7 cells by new titanocene complexes.
    Chimento A; Saturnino C; Iacopetta D; Mazzotta R; Caruso A; Plutino MR; Mariconda A; Ramunno A; Sinicropi MS; Pezzi V; Longo P
    Bioorg Med Chem; 2015 Nov; 23(22):7302-12. PubMed ID: 26526741
    [TBL] [Abstract][Full Text] [Related]  

  • 54. New modulated design and synthesis of quercetin-Cu(II)/Zn(II)-Sn2(IV) scaffold as anticancer agents: in vitro DNA binding profile, DNA cleavage pathway and Topo-I activity.
    Tabassum S; Zaki M; Afzal M; Arjmand F
    Dalton Trans; 2013 Jul; 42(27):10029-41. PubMed ID: 23715526
    [TBL] [Abstract][Full Text] [Related]  

  • 55. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
    Zhao W; Chen L; Li HM; Wang DJ; Li DS; Chen T; Yuan ZP; Tang YJ
    Bioorg Med Chem; 2014 Jun; 22(11):2998-3007. PubMed ID: 24775914
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Synthesis and biological research of novel azaacridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors.
    Li D; Yuan Z; Chen S; Zhang C; Song L; Gao C; Chen Y; Tan C; Jiang Y
    Bioorg Med Chem; 2017 Jul; 25(13):3437-3446. PubMed ID: 28511910
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents.
    Magar TBT; Seo SH; Kadayat TM; Jo H; Shrestha A; Bist G; Katila P; Kwon Y; Lee ES
    Bioorg Med Chem; 2018 May; 26(8):1909-1919. PubMed ID: 29510948
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Novel diindoloazepinone derivatives as DNA minor groove binding agents with selective topoisomerase I inhibition: Design, synthesis, biological evaluation and docking studies.
    Kadagathur M; Devi GP; Grewal P; Sigalapalli DK; Makhal PN; Banerjee UC; Bathini NB; Tangellamudi ND
    Bioorg Chem; 2020 Jun; 99():103629. PubMed ID: 32272367
    [TBL] [Abstract][Full Text] [Related]  

  • 59. A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships.
    Shrestha A; Park S; Jang HJ; Katila P; Shrestha R; Kwon Y; Lee ES
    Bioorg Med Chem; 2018 Oct; 26(18):5212-5223. PubMed ID: 30262132
    [TBL] [Abstract][Full Text] [Related]  

  • 60. 4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships.
    Kunwar S; Hwang SY; Katila P; Seo M; Man Kadayat T; Kwon Y; Lee ES
    Bioorg Chem; 2021 Nov; 116():105349. PubMed ID: 34536927
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 18.