BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

274 related articles for article (PubMed ID: 26338984)

  • 1. New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.
    Ohshiro T; Ohtawa M; Nagamitsu T; Matsuda D; Yagyu H; Davis MA; Rudel LL; Ishibashi S; Tomoda H
    J Pharmacol Exp Ther; 2015 Nov; 355(2):299-307. PubMed ID: 26338984
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.
    Ohshiro T; Matsuda D; Sakai K; Degirolamo C; Yagyu H; Rudel LL; Omura S; Ishibashi S; Tomoda H
    Arterioscler Thromb Vasc Biol; 2011 May; 31(5):1108-15. PubMed ID: 21393580
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.
    Ohtawa M; Yamazaki H; Ohte S; Matsuda D; Ohshiro T; Rudel LL; Ōmura S; Tomoda H; Nagamitsu T
    Bioorg Med Chem Lett; 2013 Jul; 23(13):3798-801. PubMed ID: 23711919
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2.
    Zhang J; Sawyer JK; Marshall SM; Kelley KL; Davis MA; Wilson MD; Brown JM; Rudel LL
    Circ Res; 2014 Oct; 115(10):826-33. PubMed ID: 25239141
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors.
    Ohtawa M; Arima S; Ichida N; Terayama T; Ohno H; Yamazaki T; Ohshiro T; Sato N; Omura S; Tomoda H; Nagamitsu T
    ChemMedChem; 2018 Mar; 13(5):411-421. PubMed ID: 29323466
    [TBL] [Abstract][Full Text] [Related]  

  • 6. PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice.
    Lopez AM; Chuang JC; Posey KS; Ohshiro T; Tomoda H; Rudel LL; Turley SD
    J Pharmacol Exp Ther; 2015 Nov; 355(2):159-67. PubMed ID: 26283692
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.
    Ohtawa M; Yamazaki H; Ohte S; Matsuda D; Ohshiro T; Rudel LL; Omura S; Tomoda H; Nagamitsu T
    Bioorg Med Chem Lett; 2013 Mar; 23(5):1285-7. PubMed ID: 23369538
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice.
    Bell TA; Kelley K; Wilson MD; Sawyer JK; Rudel LL
    Arterioscler Thromb Vasc Biol; 2007 Jun; 27(6):1396-402. PubMed ID: 17431188
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.
    Lee RG; Kelley KL; Sawyer JK; Farese RV; Parks JS; Rudel LL
    Circ Res; 2004 Nov; 95(10):998-1004. PubMed ID: 15486318
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme.
    Ohshiro T; Ohte S; Matsuda D; Ohtawa M; Nagamitsu T; Sunazuka T; Harigaya Y; Rudel LL; Omura S; Tomoda H
    J Antibiot (Tokyo); 2008 Aug; 61(8):503-8. PubMed ID: 18997389
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice.
    Bell TA; Brown JM; Graham MJ; Lemonidis KM; Crooke RM; Rudel LL
    Arterioscler Thromb Vasc Biol; 2006 Aug; 26(8):1814-20. PubMed ID: 16675724
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol O-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice.
    Ohshiro T; Imuta S; Hijikuro I; Yagyu H; Takahashi T; Doi T; Ishibashi S; Tomoda H
    Biol Pharm Bull; 2020; 43(6):951-958. PubMed ID: 32475917
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Direct effect of an acyl-CoA:cholesterol acyltransferase inhibitor, F-1394, on atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice.
    Chiwata T; Aragane K; Fujinami K; Kojima K; Ishibashi S; Yamada N; Kusunoki J
    Br J Pharmacol; 2001 Aug; 133(7):1005-12. PubMed ID: 11487509
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia.
    Xu L; Dai Perrard X; Perrard JL; Yang D; Xiao X; Teng BB; Simon SI; Ballantyne CM; Wu H
    Arterioscler Thromb Vasc Biol; 2015 Aug; 35(8):1787-97. PubMed ID: 26112011
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.
    Ohtawa M; Yamazaki H; Matsuda D; Ohshiro T; Rudel LL; Ōmura S; Tomoda H; Nagamitsu T
    Bioorg Med Chem Lett; 2013 May; 23(9):2659-62. PubMed ID: 23535327
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).
    Zhan Y; Zhang XW; Xiong Y; Li BL; Nan FJ
    Org Biomol Chem; 2016 Jan; 14(2):747-751. PubMed ID: 26584338
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.
    Marshall SM; Gromovsky AD; Kelley KL; Davis MA; Wilson MD; Lee RG; Crooke RM; Graham MJ; Rudel LL; Brown JM; Temel RE
    PLoS One; 2014; 9(6):e98953. PubMed ID: 24901470
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
    Accad M; Smith SJ; Newland DL; Sanan DA; King LE; Linton MF; Fazio S; Farese RV
    J Clin Invest; 2000 Mar; 105(6):711-9. PubMed ID: 10727439
    [TBL] [Abstract][Full Text] [Related]  

  • 19. LDL cholesteryl oleate: a biomarker for atherosclerosis?
    Spector AA; Haynes WG
    Arterioscler Thromb Vasc Biol; 2007 Jun; 27(6):1228-30. PubMed ID: 17522395
    [No Abstract]   [Full Text] [Related]  

  • 20. Identification of the interaction site within acyl-CoA:cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A.
    Das A; Davis MA; Tomoda H; Omura S; Rudel LL
    J Biol Chem; 2008 Apr; 283(16):10453-60. PubMed ID: 18285335
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.