447 related articles for article (PubMed ID: 26341912)
1. New screening strategy and analysis for identification of allosteric modulators for glucagon-like peptide-1 receptor using GLP-1 (9-36) amide.
Nakane A; Gotoh Y; Ichihara J; Nagata H
Anal Biochem; 2015 Dec; 491():23-30. PubMed ID: 26341912
[TBL] [Abstract][Full Text] [Related]
2. A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors.
Morris LC; Days EL; Turney M; Mi D; Lindsley CW; Weaver CD; Niswender KD
J Biomol Screen; 2014 Jul; 19(6):847-58. PubMed ID: 24525870
[TBL] [Abstract][Full Text] [Related]
3. Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site.
Wang J; Yang D; Cheng X; Yang L; Wang Z; Dai A; Cai X; Zhang C; Yuliantie E; Liu Q; Jiang H; Liu H; Wang MW; Yang H
ACS Chem Biol; 2021 Nov; 16(11):2444-2452. PubMed ID: 34570476
[TBL] [Abstract][Full Text] [Related]
4. Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles.
Bueno AB; Showalter AD; Wainscott DB; Stutsman C; Marín A; Ficorilli J; Cabrera O; Willard FS; Sloop KW
J Biol Chem; 2016 May; 291(20):10700-15. PubMed ID: 26975372
[TBL] [Abstract][Full Text] [Related]
5. Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1.
Hager MV; Clydesdale L; Gellman SH; Sexton PM; Wootten D
Biochem Pharmacol; 2017 Jul; 136():99-108. PubMed ID: 28363772
[TBL] [Abstract][Full Text] [Related]
6. Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor.
Li N; Lu J; Willars GB
PLoS One; 2012; 7(10):e47936. PubMed ID: 23094100
[TBL] [Abstract][Full Text] [Related]
7. Discovery of a potential positive allosteric modulator of glucagon-like peptide 1 receptor through virtual screening and experimental study.
Redij T; Ma J; Li Z; Hua X; Li Z
J Comput Aided Mol Des; 2019 Nov; 33(11):973-981. PubMed ID: 31758355
[TBL] [Abstract][Full Text] [Related]
8. The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively.
Al-Sabah S; Al-Fulaij M; Shaaban G; Ahmed HA; Mann RJ; Donnelly D; Bünemann M; Krasel C
PLoS One; 2014; 9(9):e106890. PubMed ID: 25191754
[TBL] [Abstract][Full Text] [Related]
9. Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors.
Jones B; McGlone ER; Fang Z; Pickford P; Corrêa IR; Oishi A; Jockers R; Inoue A; Kumar S; Görlitz F; Dunsby C; French PMW; Rutter GA; Tan T; Tomas A; Bloom SR
J Biol Chem; 2021; 296():100133. PubMed ID: 33268378
[TBL] [Abstract][Full Text] [Related]
10. Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.
Willard FS; Wootten D; Showalter AD; Savage EE; Ficorilli J; Farb TB; Bokvist K; Alsina-Fernandez J; Furness SG; Christopoulos A; Sexton PM; Sloop KW
Mol Pharmacol; 2012 Dec; 82(6):1066-73. PubMed ID: 22930710
[TBL] [Abstract][Full Text] [Related]
11. GRK Inhibition Potentiates Glucagon-Like Peptide-1 Action.
Lee SP; Qi J; Xu G; Rankin MM; Littrell J; Xu JZ; Bakaj I; Pocai A
Front Endocrinol (Lausanne); 2021; 12():652628. PubMed ID: 34054727
[TBL] [Abstract][Full Text] [Related]
12. Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.
Koole C; Wootten D; Simms J; Miller LJ; Christopoulos A; Sexton PM
J Pharmacol Exp Ther; 2015 Apr; 353(1):52-63. PubMed ID: 25630467
[TBL] [Abstract][Full Text] [Related]
13. Design, Synthesis, and Pharmacological Evaluation of Potent Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor (GLP-1R).
Méndez M; Matter H; Defossa E; Kurz M; Lebreton S; Li Z; Lohmann M; Löhn M; Mors H; Podeschwa M; Rackelmann N; Riedel J; Safar P; Thorpe DS; Schäfer M; Weitz D; Breitschopf K
J Med Chem; 2020 Mar; 63(5):2292-2307. PubMed ID: 31596080
[TBL] [Abstract][Full Text] [Related]
14. Identifying glucagon-like peptide-1 mimetics using a novel functional reporter gene high-throughput screening assay.
Chen J; Bai G; Yang Y; Geng P; Cao Y; Zhu Y
Peptides; 2007 Apr; 28(4):928-34. PubMed ID: 17267075
[TBL] [Abstract][Full Text] [Related]
15. Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).
Yang D; de Graaf C; Yang L; Song G; Dai A; Cai X; Feng Y; Reedtz-Runge S; Hanson MA; Yang H; Jiang H; Stevens RC; Wang MW
J Biol Chem; 2016 Jun; 291(25):12991-3004. PubMed ID: 27059958
[TBL] [Abstract][Full Text] [Related]
16. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.
Estall JL; Koehler JA; Yusta B; Drucker DJ
J Biol Chem; 2005 Jun; 280(23):22124-34. PubMed ID: 15817468
[TBL] [Abstract][Full Text] [Related]
17. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.
Koole C; Wootten D; Simms J; Miller LJ; Christopoulos A; Sexton PM
J Biol Chem; 2012 Feb; 287(6):3642-58. PubMed ID: 22147710
[TBL] [Abstract][Full Text] [Related]
18. Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism.
Lei S; Clydesdale L; Dai A; Cai X; Feng Y; Yang D; Liang YL; Koole C; Zhao P; Coudrat T; Christopoulos A; Wang MW; Wootten D; Sexton PM
J Biol Chem; 2018 Jun; 293(24):9370-9387. PubMed ID: 29717000
[TBL] [Abstract][Full Text] [Related]
19. Identification of expression and function of the glucagon-like peptide-1 receptor in colonic smooth muscle.
May AT; Crowe MS; Blakeney BA; Mahavadi S; Wang H; Grider JR; Murthy KS
Peptides; 2019 Feb; 112():48-55. PubMed ID: 30508636
[TBL] [Abstract][Full Text] [Related]
20. Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor.
Willard FS; Wainscott DB; Showalter AD; Stutsman C; Ma W; Cardona GR; Zink RW; Corkins CM; Chen Q; Yumibe N; Agejas J; Cumming GR; Minguez JM; Jiménez A; Mateo AI; Castaño AM; Briere DA; Sloop KW; Bueno AB
J Med Chem; 2021 Mar; 64(6):3439-3448. PubMed ID: 33721487
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
