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2. N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity. Kehlen A; Haegele M; Böhme L; Cynis H; Hoffmann T; Demuth HU Biosci Rep; 2017 Aug; 37(4):. PubMed ID: 28739588 [TBL] [Abstract][Full Text] [Related]
3. Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC. Höfling C; Indrischek H; Höpcke T; Waniek A; Cynis H; Koch B; Schilling S; Morawski M; Demuth HU; Roßner S; Hartlage-Rübsamen M Int J Dev Neurosci; 2014 Aug; 36():64-73. PubMed ID: 24886834 [TBL] [Abstract][Full Text] [Related]
4. Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics. Stephan A; Wermann M; von Bohlen A; Koch B; Cynis H; Demuth HU; Schilling S FEBS J; 2009 Nov; 276(22):6522-36. PubMed ID: 19804409 [TBL] [Abstract][Full Text] [Related]
5. Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development. Schilling S; Kohlmann S; Bäuscher C; Sedlmeier R; Koch B; Eichentopf R; Becker A; Cynis H; Hoffmann T; Berg S; Freyse EJ; von Hörsten S; Rossner S; Graubner S; Demuth HU J Biol Chem; 2011 Apr; 286(16):14199-208. PubMed ID: 21330373 [TBL] [Abstract][Full Text] [Related]
6. Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease. Hartlage-Rübsamen M; Waniek A; Meissner J; Morawski M; Schilling S; Jäger C; Kleinschmidt M; Cynis H; Kehlen A; Arendt T; Demuth HU; Rossner S Acta Neuropathol; 2015 Apr; 129(4):565-83. PubMed ID: 25666182 [TBL] [Abstract][Full Text] [Related]
7. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. Cynis H; Rahfeld JU; Stephan A; Kehlen A; Koch B; Wermann M; Demuth HU; Schilling S J Mol Biol; 2008 Jun; 379(5):966-80. PubMed ID: 18486145 [TBL] [Abstract][Full Text] [Related]
8. The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions. Cynis H; Hoffmann T; Friedrich D; Kehlen A; Gans K; Kleinschmidt M; Rahfeld JU; Wolf R; Wermann M; Stephan A; Haegele M; Sedlmeier R; Graubner S; Jagla W; Müller A; Eichentopf R; Heiser U; Seifert F; Quax PH; de Vries MR; Hesse I; Trautwein D; Wollert U; Berg S; Freyse EJ; Schilling S; Demuth HU EMBO Mol Med; 2011 Sep; 3(9):545-58. PubMed ID: 21774078 [TBL] [Abstract][Full Text] [Related]
9. Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice. Cynis H; Kehlen A; Haegele M; Hoffmann T; Heiser U; Fujii M; Shibazaki Y; Yoneyama H; Schilling S; Demuth HU Int J Exp Pathol; 2013 Jun; 94(3):217-25. PubMed ID: 23560443 [TBL] [Abstract][Full Text] [Related]
10. Role of glutaminyl cyclases in thyroid carcinomas. Kehlen A; Haegele M; Menge K; Gans K; Immel UD; Hoang-Vu C; Klonisch T; Demuth HU Endocr Relat Cancer; 2013 Feb; 20(1):79-90. PubMed ID: 23183267 [TBL] [Abstract][Full Text] [Related]
11. Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes. Waniek A; Hartlage-Rübsamen M; Höfling C; Kehlen A; Schilling S; Demuth HU; Roßner S Biochim Biophys Acta; 2015 Jan; 1852(1):146-55. PubMed ID: 25446989 [TBL] [Abstract][Full Text] [Related]
12. Focal Cerebral Ischemia Induces Expression of Glutaminyl Cyclase along with Downstream Molecular and Cellular Inflammatory Responses. Höfling C; Ulrich L; Burghardt S; Donkersloot P; Opitz M; Geissler S; Schilling S; Cynis H; Michalski D; Roßner S Cells; 2024 Aug; 13(17):. PubMed ID: 39272984 [TBL] [Abstract][Full Text] [Related]
13. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta. Cynis H; Scheel E; Saido TC; Schilling S; Demuth HU Biochemistry; 2008 Jul; 47(28):7405-13. PubMed ID: 18570439 [TBL] [Abstract][Full Text] [Related]
14. Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms. Hartlage-Rübsamen M; Morawski M; Waniek A; Jäger C; Zeitschel U; Koch B; Cynis H; Schilling S; Schliebs R; Demuth HU; Rossner S Acta Neuropathol; 2011 Jun; 121(6):705-19. PubMed ID: 21301857 [TBL] [Abstract][Full Text] [Related]
15. Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease. Morawski M; Schilling S; Kreuzberger M; Waniek A; Jäger C; Koch B; Cynis H; Kehlen A; Arendt T; Hartlage-Rübsamen M; Demuth HU; Roßner S J Alzheimers Dis; 2014; 39(2):385-400. PubMed ID: 24164736 [TBL] [Abstract][Full Text] [Related]
16. Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization. Schilling S; Lindner C; Koch B; Wermann M; Rahfeld JU; von Bohlen A; Rudolph T; Reuter G; Demuth HU Biochemistry; 2007 Sep; 46(38):10921-30. PubMed ID: 17722885 [TBL] [Abstract][Full Text] [Related]
17. Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells. Cynis H; Schilling S; Bodnár M; Hoffmann T; Heiser U; Saido TC; Demuth HU Biochim Biophys Acta; 2006 Oct; 1764(10):1618-25. PubMed ID: 17005457 [TBL] [Abstract][Full Text] [Related]
18. Substrate specificity of glutaminyl cyclases from plants and animals. Schilling S; Manhart S; Hoffmann T; Ludwig HH; Wasternack C; Demuth HU Biol Chem; 2003 Dec; 384(12):1583-92. PubMed ID: 14719800 [TBL] [Abstract][Full Text] [Related]
19. Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Morawski M; Hartlage-Rübsamen M; Jäger C; Waniek A; Schilling S; Schwab C; McGeer PL; Arendt T; Demuth HU; Rossner S Acta Neuropathol; 2010 Aug; 120(2):195-207. PubMed ID: 20383514 [TBL] [Abstract][Full Text] [Related]
20. Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ. Schilling S; Appl T; Hoffmann T; Cynis H; Schulz K; Jagla W; Friedrich D; Wermann M; Buchholz M; Heiser U; von Hörsten S; Demuth HU J Neurochem; 2008 Aug; 106(3):1225-36. PubMed ID: 18627432 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]