245 related articles for article (PubMed ID: 26363026)
1. Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists.
Hutzler JM; Ring BJ; Anderson SR
Drug Metab Dispos; 2015 Dec; 43(12):1917-28. PubMed ID: 26363026
[TBL] [Abstract][Full Text] [Related]
2. Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac.
Chan TS; Yu H; Moore A; Khetani SR; Tweedie D
Drug Metab Dispos; 2013 Dec; 41(12):2024-32. PubMed ID: 23959596
[TBL] [Abstract][Full Text] [Related]
3. Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.
Wang WW; Khetani SR; Krzyzewski S; Duignan DB; Obach RS
Drug Metab Dispos; 2010 Oct; 38(10):1900-5. PubMed ID: 20595376
[TBL] [Abstract][Full Text] [Related]
4. Assessment of the Biotransformation of Low-Turnover Drugs in the H
Burton RD; Hieronymus T; Chamem T; Heim D; Anderson S; Zhu X; Hutzler JM
Drug Metab Dispos; 2018 Nov; 46(11):1617-1625. PubMed ID: 30135244
[TBL] [Abstract][Full Text] [Related]
5. Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG.
Bonn B; Svanberg P; Janefeldt A; Hultman Ia; Grime K
Drug Metab Dispos; 2016 Apr; 44(4):527-33. PubMed ID: 26851239
[TBL] [Abstract][Full Text] [Related]
6. Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations.
Jones HM; Houston JB
Drug Metab Dispos; 2004 Sep; 32(9):973-82. PubMed ID: 15319339
[TBL] [Abstract][Full Text] [Related]
7. Generation of major human excretory and circulating drug metabolites using a hepatocyte relay method.
Ballard TE; Orozco CC; Obach RS
Drug Metab Dispos; 2014 May; 42(5):899-902. PubMed ID: 24608634
[TBL] [Abstract][Full Text] [Related]
8. Reaction Phenotyping of Low-Turnover Compounds in Long-Term Hepatocyte Cultures Through Persistent Selective Inhibition of Cytochromes P450.
Smith S; Lyman M; Ma B; Tweedie D; Menzel K
Drug Metab Dispos; 2021 Nov; 49(11):995-1002. PubMed ID: 34407991
[TBL] [Abstract][Full Text] [Related]
9. Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac.
Chan TS; Yu H; Moore A; Khetani SR; Tweedie D
Drug Metab Dispos; 2019 Jan; 47(1):58-66. PubMed ID: 30552098
[TBL] [Abstract][Full Text] [Related]
10. Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds.
Preiss LC; Georgi K; Lauschke VM; Petersson C
Drug Metab Dispos; 2024 May; 52(6):539-547. PubMed ID: 38604730
[TBL] [Abstract][Full Text] [Related]
11. Prediction of in vivo rat biliary drug clearance from an in vitro hepatocyte efflux model.
Lundquist P; Lööf J; Fagerholm U; Sjögren I; Johansson J; Briem S; Hoogstraate J; Afzelius L; Andersson TB
Drug Metab Dispos; 2014 Mar; 42(3):459-68. PubMed ID: 24396143
[TBL] [Abstract][Full Text] [Related]
12. The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions.
Lundquist P; Lööf J; Sohlenius-Sternbeck AK; Floby E; Johansson J; Bylund J; Hoogstraate J; Afzelius L; Andersson TB
Drug Metab Dispos; 2014 Mar; 42(3):469-80. PubMed ID: 24396146
[TBL] [Abstract][Full Text] [Related]
13. Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism.
Liu Y; Wei J; Lu J; Lei D; Yan S; Li X
Mater Sci Eng C Mater Biol Appl; 2016 Jun; 63():475-84. PubMed ID: 27040241
[TBL] [Abstract][Full Text] [Related]
14. In Vitro Metabolism of Slowly Cleared G Protein-Coupled Receptor 139 Agonist TAK-041 Using Rat, Dog, Monkey, and Human Hepatocyte Models (HepatoPac): Correlation with In Vivo Metabolism.
Kamel A; Bowlin S; Hosea N; Arkilo D; Laurenza A
Drug Metab Dispos; 2021 Feb; 49(2):121-132. PubMed ID: 33273044
[TBL] [Abstract][Full Text] [Related]
15. Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds.
Hultman Ia; Vedin C; Abrahamsson A; Winiwarter S; Darnell M
Mol Pharm; 2016 Aug; 13(8):2796-807. PubMed ID: 27377099
[TBL] [Abstract][Full Text] [Related]
16. Advances in Engineered Human Liver Platforms for Drug Metabolism Studies.
Underhill GH; Khetani SR
Drug Metab Dispos; 2018 Nov; 46(11):1626-1637. PubMed ID: 30135245
[TBL] [Abstract][Full Text] [Related]
17. Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance.
McGinnity DF; Soars MG; Urbanowicz RA; Riley RJ
Drug Metab Dispos; 2004 Nov; 32(11):1247-53. PubMed ID: 15286053
[TBL] [Abstract][Full Text] [Related]
18. Application of chimeric mice with humanized liver for study of human-specific drug metabolism.
Bateman TJ; Reddy VG; Kakuni M; Morikawa Y; Kumar S
Drug Metab Dispos; 2014 Jun; 42(6):1055-65. PubMed ID: 24700822
[TBL] [Abstract][Full Text] [Related]
19. A novel relay method for determining low-clearance values.
Di L; Trapa P; Obach RS; Atkinson K; Bi YA; Wolford AC; Tan B; McDonald TS; Lai Y; Tremaine LM
Drug Metab Dispos; 2012 Sep; 40(9):1860-5. PubMed ID: 22645091
[TBL] [Abstract][Full Text] [Related]
20. Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.
Di L; Keefer C; Scott DO; Strelevitz TJ; Chang G; Bi YA; Lai Y; Duckworth J; Fenner K; Troutman MD; Obach RS
Eur J Med Chem; 2012 Nov; 57():441-8. PubMed ID: 22840492
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
