352 related articles for article (PubMed ID: 26368822)
1. Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation.
Ding Q; Zhao M; Yu B; Bai C; Huang Z
PLoS One; 2015; 10(9):e0137711. PubMed ID: 26368822
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of RORγt activity and Th17 differentiation by a set of novel compounds.
Ding Q; Zhao M; Bai C; Yu B; Huang Z
BMC Immunol; 2015 May; 16():32. PubMed ID: 26021566
[TBL] [Abstract][Full Text] [Related]
3. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
Skepner J; Ramesh R; Trocha M; Schmidt D; Baloglu E; Lobera M; Carlson T; Hill J; Orband-Miller LA; Barnes A; Boudjelal M; Sundrud M; Ghosh S; Yang J
J Immunol; 2014 Mar; 192(6):2564-75. PubMed ID: 24516202
[TBL] [Abstract][Full Text] [Related]
4. Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production.
Fujita-Sato S; Ito S; Isobe T; Ohyama T; Wakabayashi K; Morishita K; Ando O; Isono F
J Biol Chem; 2011 Sep; 286(36):31409-17. PubMed ID: 21733845
[TBL] [Abstract][Full Text] [Related]
5. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.
Huh JR; Leung MW; Huang P; Ryan DA; Krout MR; Malapaka RR; Chow J; Manel N; Ciofani M; Kim SV; Cuesta A; Santori FR; Lafaille JJ; Xu HE; Gin DY; Rastinejad F; Littman DR
Nature; 2011 Apr; 472(7344):486-90. PubMed ID: 21441909
[TBL] [Abstract][Full Text] [Related]
6. Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses.
Ecoeur F; Weiss J; Kaupmann K; Hintermann S; Orain D; Guntermann C
Front Immunol; 2019; 10():577. PubMed ID: 30972071
[TBL] [Abstract][Full Text] [Related]
7. Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity.
Pastwińska J; Karaś K; Sałkowska A; Karwaciak I; Chałaśkiewicz K; Wojtczak BA; Bachorz RA; Ratajewski M
Int J Mol Sci; 2022 Feb; 23(3):. PubMed ID: 35163824
[TBL] [Abstract][Full Text] [Related]
8. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.
Guendisch U; Weiss J; Ecoeur F; Riker JC; Kaupmann K; Kallen J; Hintermann S; Orain D; Dawson J; Billich A; Guntermann C
PLoS One; 2017; 12(11):e0188391. PubMed ID: 29155882
[TBL] [Abstract][Full Text] [Related]
9. High Throughput Screening Assay to Identify Modulators of IL-17 Expression.
Boudjelal M; Ruiz-Avendano AM; Colmenarejo G; Senar-Sancho SA; Barnes A; Harrison SA
Comb Chem High Throughput Screen; 2017; 20(9):804-819. PubMed ID: 28571538
[TBL] [Abstract][Full Text] [Related]
10. Inhibiting RORγt/Th17 axis for autoimmune disorders.
Isono F; Fujita-Sato S; Ito S
Drug Discov Today; 2014 Aug; 19(8):1205-11. PubMed ID: 24792721
[TBL] [Abstract][Full Text] [Related]
11. Targeting Th17 Cells with Small Molecules and Small Interference RNA.
Lin H; Song P; Zhao Y; Xue LJ; Liu Y; Chu CQ
Mediators Inflamm; 2015; 2015():290657. PubMed ID: 26792955
[TBL] [Abstract][Full Text] [Related]
12. Targeting Th17 cells in autoimmune diseases.
Yang J; Sundrud MS; Skepner J; Yamagata T
Trends Pharmacol Sci; 2014 Oct; 35(10):493-500. PubMed ID: 25131183
[TBL] [Abstract][Full Text] [Related]
13. 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt.
Lao C; Zhou X; Chen H; Wei F; Huang Z; Bai C
Bioorg Chem; 2019 Sep; 90():103077. PubMed ID: 31323598
[TBL] [Abstract][Full Text] [Related]
14. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003.
Sasaki Y; Odan M; Yamamoto S; Kida S; Ueyama A; Shimizu M; Haruna T; Watanabe A; Okuno T
Bioorg Med Chem Lett; 2018 Dec; 28(22):3549-3553. PubMed ID: 30301676
[TBL] [Abstract][Full Text] [Related]
15. AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor γt-induced Th17 cell differentiation.
Saito Y; Kagami S; Sanayama Y; Ikeda K; Suto A; Kashiwakuma D; Furuta S; Iwamoto I; Nonaka K; Ohara O; Nakajima H
Arthritis Rheumatol; 2014 May; 66(5):1185-94. PubMed ID: 24782182
[TBL] [Abstract][Full Text] [Related]
16. Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation.
Tan J; Liu H; Huang M; Li N; Tang S; Meng J; Tang S; Zhou H; Kijlstra A; Yang P; Hou S
Cell Death Dis; 2020 Aug; 11(8):697. PubMed ID: 32829384
[TBL] [Abstract][Full Text] [Related]
17. In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists.
Skepner J; Trocha M; Ramesh R; Qu XA; Schmidt D; Baloglu E; Lobera M; Davis S; Nolan MA; Carlson TJ; Hill J; Ghosh S; Sundrud MS; Yang J
Immunology; 2015 Jul; 145(3):347-56. PubMed ID: 25604624
[TBL] [Abstract][Full Text] [Related]
18. Concomitant suppression of T
Na H; Lim H; Choi G; Kim BK; Kim SH; Chang YS; Nurieva R; Dong C; Chang SH; Chung Y
J Allergy Clin Immunol; 2018 Jun; 141(6):2061-2073.e5. PubMed ID: 28943467
[TBL] [Abstract][Full Text] [Related]
19. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
Solt LA; Kumar N; Nuhant P; Wang Y; Lauer JL; Liu J; Istrate MA; Kamenecka TM; Roush WR; Vidović D; Schürer SC; Xu J; Wagoner G; Drew PD; Griffin PR; Burris TP
Nature; 2011 Apr; 472(7344):491-4. PubMed ID: 21499262
[TBL] [Abstract][Full Text] [Related]
20. IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis.
Yamashita T; Iwakura T; Matsui K; Kawaguchi H; Obana M; Hayama A; Maeda M; Izumi Y; Komuro I; Ohsugi Y; Fujimoto M; Naka T; Kishimoto T; Nakayama H; Fujio Y
Cardiovasc Res; 2011 Sep; 91(4):640-8. PubMed ID: 21622681
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]