BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

352 related articles for article (PubMed ID: 26368822)

  • 1. Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation.
    Ding Q; Zhao M; Yu B; Bai C; Huang Z
    PLoS One; 2015; 10(9):e0137711. PubMed ID: 26368822
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of RORγt activity and Th17 differentiation by a set of novel compounds.
    Ding Q; Zhao M; Bai C; Yu B; Huang Z
    BMC Immunol; 2015 May; 16():32. PubMed ID: 26021566
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
    Skepner J; Ramesh R; Trocha M; Schmidt D; Baloglu E; Lobera M; Carlson T; Hill J; Orband-Miller LA; Barnes A; Boudjelal M; Sundrud M; Ghosh S; Yang J
    J Immunol; 2014 Mar; 192(6):2564-75. PubMed ID: 24516202
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production.
    Fujita-Sato S; Ito S; Isobe T; Ohyama T; Wakabayashi K; Morishita K; Ando O; Isono F
    J Biol Chem; 2011 Sep; 286(36):31409-17. PubMed ID: 21733845
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.
    Huh JR; Leung MW; Huang P; Ryan DA; Krout MR; Malapaka RR; Chow J; Manel N; Ciofani M; Kim SV; Cuesta A; Santori FR; Lafaille JJ; Xu HE; Gin DY; Rastinejad F; Littman DR
    Nature; 2011 Apr; 472(7344):486-90. PubMed ID: 21441909
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses.
    Ecoeur F; Weiss J; Kaupmann K; Hintermann S; Orain D; Guntermann C
    Front Immunol; 2019; 10():577. PubMed ID: 30972071
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity.
    Pastwińska J; Karaś K; Sałkowska A; Karwaciak I; Chałaśkiewicz K; Wojtczak BA; Bachorz RA; Ratajewski M
    Int J Mol Sci; 2022 Feb; 23(3):. PubMed ID: 35163824
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.
    Guendisch U; Weiss J; Ecoeur F; Riker JC; Kaupmann K; Kallen J; Hintermann S; Orain D; Dawson J; Billich A; Guntermann C
    PLoS One; 2017; 12(11):e0188391. PubMed ID: 29155882
    [TBL] [Abstract][Full Text] [Related]  

  • 9. High Throughput Screening Assay to Identify Modulators of IL-17 Expression.
    Boudjelal M; Ruiz-Avendano AM; Colmenarejo G; Senar-Sancho SA; Barnes A; Harrison SA
    Comb Chem High Throughput Screen; 2017; 20(9):804-819. PubMed ID: 28571538
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibiting RORγt/Th17 axis for autoimmune disorders.
    Isono F; Fujita-Sato S; Ito S
    Drug Discov Today; 2014 Aug; 19(8):1205-11. PubMed ID: 24792721
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeting Th17 Cells with Small Molecules and Small Interference RNA.
    Lin H; Song P; Zhao Y; Xue LJ; Liu Y; Chu CQ
    Mediators Inflamm; 2015; 2015():290657. PubMed ID: 26792955
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting Th17 cells in autoimmune diseases.
    Yang J; Sundrud MS; Skepner J; Yamagata T
    Trends Pharmacol Sci; 2014 Oct; 35(10):493-500. PubMed ID: 25131183
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt.
    Lao C; Zhou X; Chen H; Wei F; Huang Z; Bai C
    Bioorg Chem; 2019 Sep; 90():103077. PubMed ID: 31323598
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003.
    Sasaki Y; Odan M; Yamamoto S; Kida S; Ueyama A; Shimizu M; Haruna T; Watanabe A; Okuno T
    Bioorg Med Chem Lett; 2018 Dec; 28(22):3549-3553. PubMed ID: 30301676
    [TBL] [Abstract][Full Text] [Related]  

  • 15. AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor γt-induced Th17 cell differentiation.
    Saito Y; Kagami S; Sanayama Y; Ikeda K; Suto A; Kashiwakuma D; Furuta S; Iwamoto I; Nonaka K; Ohara O; Nakajima H
    Arthritis Rheumatol; 2014 May; 66(5):1185-94. PubMed ID: 24782182
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation.
    Tan J; Liu H; Huang M; Li N; Tang S; Meng J; Tang S; Zhou H; Kijlstra A; Yang P; Hou S
    Cell Death Dis; 2020 Aug; 11(8):697. PubMed ID: 32829384
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists.
    Skepner J; Trocha M; Ramesh R; Qu XA; Schmidt D; Baloglu E; Lobera M; Davis S; Nolan MA; Carlson TJ; Hill J; Ghosh S; Sundrud MS; Yang J
    Immunology; 2015 Jul; 145(3):347-56. PubMed ID: 25604624
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Concomitant suppression of T
    Na H; Lim H; Choi G; Kim BK; Kim SH; Chang YS; Nurieva R; Dong C; Chang SH; Chung Y
    J Allergy Clin Immunol; 2018 Jun; 141(6):2061-2073.e5. PubMed ID: 28943467
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
    Solt LA; Kumar N; Nuhant P; Wang Y; Lauer JL; Liu J; Istrate MA; Kamenecka TM; Roush WR; Vidović D; Schürer SC; Xu J; Wagoner G; Drew PD; Griffin PR; Burris TP
    Nature; 2011 Apr; 472(7344):491-4. PubMed ID: 21499262
    [TBL] [Abstract][Full Text] [Related]  

  • 20. IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis.
    Yamashita T; Iwakura T; Matsui K; Kawaguchi H; Obana M; Hayama A; Maeda M; Izumi Y; Komuro I; Ohsugi Y; Fujimoto M; Naka T; Kishimoto T; Nakayama H; Fujio Y
    Cardiovasc Res; 2011 Sep; 91(4):640-8. PubMed ID: 21622681
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.