87 related articles for article (PubMed ID: 26370527)
1. Combination of immunoprecipitation (IP)-ATP_Glo kinase assay and melanogenesis for the assessment of potent and safe PAK1-blockers in cell culture.
Nguyen BC; Be Tu PT; Tawata S; Maruta H
Drug Discov Ther; 2015 Aug; 9(4):289-95. PubMed ID: 26370527
[TBL] [Abstract][Full Text] [Related]
2. CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice.
Demestre M; Messerli SM; Celli N; Shahhossini M; Kluwe L; Mautner V; Maruta H
Phytother Res; 2009 Feb; 23(2):226-30. PubMed ID: 18726924
[TBL] [Abstract][Full Text] [Related]
3. Artepillin C and Other Herbal PAK1-blockers: Effects on Hair Cell Proliferation and Related PAK1-dependent Biological Function in Cell Culture.
Nguyen BC; Taira N; Maruta H; Tawata S
Phytother Res; 2016 Jan; 30(1):120-7. PubMed ID: 26537230
[TBL] [Abstract][Full Text] [Related]
4. Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice.
Messerli SM; Ahn MR; Kunimasa K; Yanagihara M; Tatefuji T; Hashimoto K; Mautner V; Uto Y; Hori H; Kumazawa S; Kaji K; Ohta T; Maruta H
Phytother Res; 2009 Mar; 23(3):423-7. PubMed ID: 19003952
[TBL] [Abstract][Full Text] [Related]
5. The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay.
Be Tu PT; Nguyen BC; Tawata S; Yun CY; Kim EG; Maruta H
Drug Discov Ther; 2017 Jan; 10(6):314-322. PubMed ID: 27746419
[TBL] [Abstract][Full Text] [Related]
6. Effect of Okinawa Propolis on PAK1 Activity, Caenorhabditis elegans Longevity, Melanogenesis, and Growth of Cancer Cells.
Taira N; Nguyen BC; Be Tu PT; Tawata S
J Agric Food Chem; 2016 Jul; 64(27):5484-9. PubMed ID: 27337169
[TBL] [Abstract][Full Text] [Related]
7. 1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability.
Takahashi H; Nguyen BCQ; Uto Y; Shahinozzaman M; Tawata S; Maruta H
Drug Discov Ther; 2017 May; 11(2):104-109. PubMed ID: 28442677
[TBL] [Abstract][Full Text] [Related]
8. From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy.
Maruta H; Ahn MR
Eur J Med Chem; 2017 Dec; 142():229-243. PubMed ID: 28814374
[TBL] [Abstract][Full Text] [Related]
9. Several herbal compounds in Okinawa plants directly inhibit the oncogenic/aging kinase PAK1.
Nguyen BC; Taira N; Tawata S
Drug Discov Ther; 2014 Dec; 8(6):238-44. PubMed ID: 25639302
[TBL] [Abstract][Full Text] [Related]
10. 1,2,3-Triazolyl ester of Ketorolac: A "Click Chemistry"-based highly potent PAK1-blocking cancer-killer.
Nguyen BCQ; Takahashi H; Uto Y; Shahinozzaman MD; Tawata S; Maruta H
Eur J Med Chem; 2017 Jan; 126():270-276. PubMed ID: 27889630
[TBL] [Abstract][Full Text] [Related]
11. Rapamycin vs TORin-1 or Gleevec vs Nilotinib: Simple chemical evolution that converts PAK1-blockers to TOR-blockers or vice versa?
Maruta H; He H
Drug Discov Ther; 2024 Jun; 18(2):134-139. PubMed ID: 38569833
[TBL] [Abstract][Full Text] [Related]
12. Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro.
Nguyen BCQ; Yoshimura K; Kumazawa S; Tawata S; Maruta H
Drug Discov Ther; 2017 May; 11(2):110-114. PubMed ID: 28442678
[TBL] [Abstract][Full Text] [Related]
13. PAK1-deficiency/down-regulation reduces brood size, activates HSP16.2 gene and extends lifespan in Caenorhabditis elegans.
Yanase S; Luo Y; Maruta H
Drug Discov Ther; 2013 Feb; 7(1):29-35. PubMed ID: 23524941
[TBL] [Abstract][Full Text] [Related]
14. Hispidin and related herbal compounds from Alpinia zerumbet inhibit both PAK1-dependent melanogenesis in melanocytes and reactive oxygen species (ROS) production in adipocytes.
Be Tu PT; Chompoo J; Tawata S
Drug Discov Ther; 2015 Jun; 9(3):197-204. PubMed ID: 26193942
[TBL] [Abstract][Full Text] [Related]
15. Antitumor progression potential of caffeic acid phenethyl ester involving p75(NTR) in C6 glioma cells.
Lin WL; Liang WH; Lee YJ; Chuang SK; Tseng TH
Chem Biol Interact; 2010 Dec; 188(3):607-15. PubMed ID: 20836997
[TBL] [Abstract][Full Text] [Related]
16. Hair Growth Promoting and Anticancer Effects of p21-activated kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia zerumbet.
Taira N; Nguyen BC; Tawata S
Molecules; 2017 Jan; 22(1):. PubMed ID: 28098826
[TBL] [Abstract][Full Text] [Related]
17. Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).
Hirokawa Y; Levitzki A; Lessene G; Baell J; Xiao Y; Zhu H; Maruta H
Cancer Lett; 2007 Jan; 245(1-2):242-51. PubMed ID: 16540233
[TBL] [Abstract][Full Text] [Related]
18. In vivo and in vitro antıneoplastic actions of caffeic acid phenethyl ester (CAPE): therapeutic perspectives.
Akyol S; Ozturk G; Ginis Z; Armutcu F; Yigitoglu MR; Akyol O
Nutr Cancer; 2013; 65(4):515-26. PubMed ID: 23659443
[TBL] [Abstract][Full Text] [Related]
19. Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo.
Kuo HC; Kuo WH; Lee YJ; Lin WL; Chou FP; Tseng TH
Cancer Lett; 2006 Mar; 234(2):199-208. PubMed ID: 15885897
[TBL] [Abstract][Full Text] [Related]
20. Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.
Tabusa H; Brooks T; Massey AJ
Mol Cancer Res; 2013 Feb; 11(2):109-21. PubMed ID: 23233484
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]