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4. Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis. Wang X; Lai P; Zhang Z; Huang M; Wang L; Yin M; Jin D; Zhou R; Bai X Oncol Rep; 2014 Jul; 32(1):382-8. PubMed ID: 24840134 [TBL] [Abstract][Full Text] [Related]
5. ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma. Neil J; Shannon C; Mohan A; Laurent D; Murali R; Jhanwar-Uniyal M Int J Oncol; 2016 Mar; 48(3):1045-52. PubMed ID: 26719046 [TBL] [Abstract][Full Text] [Related]
6. Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis. Farhan MA; Carmine-Simmen K; Lewis JD; Moore RB; Murray AG PLoS One; 2015; 10(8):e0135245. PubMed ID: 26295809 [TBL] [Abstract][Full Text] [Related]
7. Rapamycin, proliferation and geroconversion to senescence. Blagosklonny MV Cell Cycle; 2018; 17(24):2655-2665. PubMed ID: 30541374 [TBL] [Abstract][Full Text] [Related]
8. Targeting of mTORC2 may have advantages over selective targeting of mTORC1 in the treatment of malignant pheochromocytoma. Zhang X; Wang X; Xu T; Zhong S; Shen Z Tumour Biol; 2015 Jul; 36(7):5273-81. PubMed ID: 25666752 [TBL] [Abstract][Full Text] [Related]
9. The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. Zhang X; Wang X; Qin L; Xu T; Zhu Z; Zhong S; Zhang M; Shen Z Urology; 2015 Jan; 85(1):273.e1-7. PubMed ID: 25440763 [TBL] [Abstract][Full Text] [Related]
10. Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island. Arriola Apelo SI; Lamming DW J Gerontol A Biol Sci Med Sci; 2016 Jul; 71(7):841-9. PubMed ID: 27208895 [TBL] [Abstract][Full Text] [Related]
11. Effect of mTORC1/mTORC2 inhibition on T cell function: potential role in graft-versus-host disease control. Herrero-Sánchez MC; Rodríguez-Serrano C; Almeida J; San-Segundo L; Inogés S; Santos-Briz Á; García-Briñón J; SanMiguel JF; Del Cañizo C; Blanco B Br J Haematol; 2016 Jun; 173(5):754-68. PubMed ID: 26914848 [TBL] [Abstract][Full Text] [Related]
12. Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer. Li H; Lin J; Wang X; Yao G; Wang L; Zheng H; Yang C; Jia C; Liu A; Bai X Breast Cancer Res Treat; 2012 Aug; 134(3):1057-66. PubMed ID: 22476852 [TBL] [Abstract][Full Text] [Related]
13. Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes. Jhanwar-Uniyal M; Gillick JL; Neil J; Tobias M; Thwing ZE; Murali R Adv Biol Regul; 2015 Jan; 57():64-74. PubMed ID: 25442674 [TBL] [Abstract][Full Text] [Related]
14. Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells. Sini P; James D; Chresta C; Guichard S Autophagy; 2010 May; 6(4):553-4. PubMed ID: 20364113 [TBL] [Abstract][Full Text] [Related]
15. Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects. Jhanwar-Uniyal M; Amin AG; Cooper JB; Das K; Schmidt MH; Murali R Adv Biol Regul; 2017 May; 64():39-48. PubMed ID: 28189457 [TBL] [Abstract][Full Text] [Related]
16. From rapalogs to anti-aging formula. Blagosklonny MV Oncotarget; 2017 May; 8(22):35492-35507. PubMed ID: 28548953 [TBL] [Abstract][Full Text] [Related]
17. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Yu K; Toral-Barza L; Shi C; Zhang WG; Lucas J; Shor B; Kim J; Verheijen J; Curran K; Malwitz DJ; Cole DC; Ellingboe J; Ayral-Kaloustian S; Mansour TS; Gibbons JJ; Abraham RT; Nowak P; Zask A Cancer Res; 2009 Aug; 69(15):6232-40. PubMed ID: 19584280 [TBL] [Abstract][Full Text] [Related]
18. Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014. Pike KG; Malagu K; Hummersone MG; Menear KA; Duggan HM; Gomez S; Martin NM; Ruston L; Pass SL; Pass M Bioorg Med Chem Lett; 2013 Mar; 23(5):1212-6. PubMed ID: 23375793 [TBL] [Abstract][Full Text] [Related]
19. mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition. Limon JJ; So L; Jellbauer S; Chiu H; Corado J; Sykes SM; Raffatellu M; Fruman DA Proc Natl Acad Sci U S A; 2014 Nov; 111(47):E5076-85. PubMed ID: 25385646 [TBL] [Abstract][Full Text] [Related]
20. Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer. Qian J; Chen Y; Meng T; Ma L; Meng L; Wang X; Yu T; Zask A; Shen J; Yu K Oncotarget; 2016 Oct; 7(41):67071-67086. PubMed ID: 27563814 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]