395 related articles for article (PubMed ID: 26386696)
1. BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans.
Sajan MP; Ivey RA; Farese RV
Metabolism; 2015 Nov; 64(11):1454-65. PubMed ID: 26386696
[TBL] [Abstract][Full Text] [Related]
2. Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance.
Sajan MP; Lee MC; Foufelle F; Sajan J; Cleland C; Farese RV
Cell Signal; 2018 Mar; 43():62-70. PubMed ID: 29269047
[TBL] [Abstract][Full Text] [Related]
3. Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
Sajan MP; Ivey RA; Lee MC; Farese RV
J Lipid Res; 2015 Jan; 56(1):70-80. PubMed ID: 25395359
[TBL] [Abstract][Full Text] [Related]
4. Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity.
Sajan MP; Acevedo-Duncan ME; Standaert ML; Ivey RA; Lee M; Farese RV
Diabetes; 2014 Aug; 63(8):2690-701. PubMed ID: 24705403
[TBL] [Abstract][Full Text] [Related]
5. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.
Sajan M; Hansen B; Ivey R; Sajan J; Ari C; Song S; Braun U; Leitges M; Farese-Higgs M; Farese RV
Diabetes; 2016 Jul; 65(7):1892-903. PubMed ID: 26895791
[TBL] [Abstract][Full Text] [Related]
6. Endurance exercise training increases APPL1 expression and improves insulin signaling in the hepatic tissue of diet-induced obese mice, independently of weight loss.
Marinho R; Ropelle ER; Cintra DE; De Souza CT; Da Silva AS; Bertoli FC; Colantonio E; D'Almeida V; Pauli JR
J Cell Physiol; 2012 Jul; 227(7):2917-26. PubMed ID: 21938726
[TBL] [Abstract][Full Text] [Related]
7. ALAS1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice.
Oliveri LM; Davio C; Batlle AM; Gerez EN
Biochem J; 2012 Mar; 442(2):303-10. PubMed ID: 22070747
[TBL] [Abstract][Full Text] [Related]
8. Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors.
Sajan MP; Farese RV
Diabetologia; 2012 May; 55(5):1446-57. PubMed ID: 22349071
[TBL] [Abstract][Full Text] [Related]
9. Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.
Sajan MP; Nimal S; Mastorides S; Acevedo-Duncan M; Kahn CR; Fields AP; Braun U; Leitges M; Farese RV
Metabolism; 2012 Apr; 61(4):459-69. PubMed ID: 22225955
[TBL] [Abstract][Full Text] [Related]
10. PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.
Southgate RJ; Bruce CR; Carey AL; Steinberg GR; Walder K; Monks R; Watt MJ; Hawley JA; Birnbaum MJ; Febbraio MA
FASEB J; 2005 Dec; 19(14):2072-4. PubMed ID: 16203862
[TBL] [Abstract][Full Text] [Related]
11. Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects.
Rametta R; Mozzi E; Dongiovanni P; Motta BM; Milano M; Roviaro G; Fargion S; Valenti L
Int J Obes (Lond); 2013 Jul; 37(7):986-92. PubMed ID: 23147115
[TBL] [Abstract][Full Text] [Related]
12. Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.
Farese RV; Sajan MP; Standaert ML
Exp Biol Med (Maywood); 2005 Oct; 230(9):593-605. PubMed ID: 16179727
[TBL] [Abstract][Full Text] [Related]
13. PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
Sajan MP; Ivey RA; Lee M; Mastorides S; Jurczak MJ; Samuels VT; Shulman GI; Braun U; Leitges M; Farese RV
Mol Endocrinol; 2014 Jul; 28(7):1097-107. PubMed ID: 24877563
[TBL] [Abstract][Full Text] [Related]
14. Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.
Sajan MP; Ivey RA; Farese RV
Diabetologia; 2013 Nov; 56(11):2507-16. PubMed ID: 23933835
[TBL] [Abstract][Full Text] [Related]
15. Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice.
Chen Z; Ding L; Yang W; Wang J; Chen L; Chang Y; Geng B; Cui Q; Guan Y; Yang J
Diabetes; 2017 May; 66(5):1185-1197. PubMed ID: 28246289
[TBL] [Abstract][Full Text] [Related]
16. Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.
Temofonte N; Sajan MP; Nimal S; Pastoor T; Fumero C; Casaubon L; Powe JL; Standaert ML; Farese RV
Diabetologia; 2009 Jan; 52(1):60-4. PubMed ID: 18972094
[TBL] [Abstract][Full Text] [Related]
17. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Puigserver P; Rhee J; Donovan J; Walkey CJ; Yoon JC; Oriente F; Kitamura Y; Altomonte J; Dong H; Accili D; Spiegelman BM
Nature; 2003 May; 423(6939):550-5. PubMed ID: 12754525
[TBL] [Abstract][Full Text] [Related]
18. IGF-II-mediated downregulation of peroxisome proliferator-activated receptor-γ coactivator-1α in myoblast cells involves PI3K/Akt/FoxO1 signaling pathway.
Mu X; Qi W; Liu Y; Zhou J; Li Y; Rong X; Lu L
Mol Cell Biochem; 2017 Aug; 432(1-2):199-208. PubMed ID: 28374141
[TBL] [Abstract][Full Text] [Related]
19. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
Valverde AM; Burks DJ; Fabregat I; Fisher TL; Carretero J; White MF; Benito M
Diabetes; 2003 Sep; 52(9):2239-48. PubMed ID: 12941762
[TBL] [Abstract][Full Text] [Related]
20. Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice.
Souza Pauli LS; Ropelle EC; de Souza CT; Cintra DE; da Silva AS; de Almeida Rodrigues B; de Moura LP; Marinho R; de Oliveira V; Katashima CK; Pauli JR; Ropelle ER
J Physiol; 2014 Mar; 592(6):1325-40. PubMed ID: 24396063
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
