BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1056 related articles for article (PubMed ID: 26392287)

  • 21. Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
    Kuo SH; Tasset I; Cheng MM; Diaz A; Pan MK; Lieberman OJ; Hutten SJ; Alcalay RN; Kim S; Ximénez-Embún P; Fan L; Kim D; Ko HS; Yacoubian T; Kanter E; Liu L; Tang G; Muñoz J; Sardi SP; Li A; Gan L; Cuervo AM; Sulzer D
    Sci Adv; 2022 Feb; 8(6):eabm6393. PubMed ID: 35138901
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson's disease.
    Papadopoulos VE; Nikolopoulou G; Antoniadou I; Karachaliou A; Arianoglou G; Emmanouilidou E; Sardi SP; Stefanis L; Vekrellis K
    Hum Mol Genet; 2018 May; 27(10):1696-1710. PubMed ID: 29547959
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson's Disease.
    He Q; Koprich JB; Wang Y; Yu WB; Xiao BG; Brotchie JM; Wang J
    Mol Neurobiol; 2016 May; 53(4):2258-68. PubMed ID: 25972237
    [TBL] [Abstract][Full Text] [Related]  

  • 24. LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients.
    Ysselstein D; Nguyen M; Young TJ; Severino A; Schwake M; Merchant K; Krainc D
    Nat Commun; 2019 Dec; 10(1):5570. PubMed ID: 31804465
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The effect of mutant GBA1 on accumulation and aggregation of α-synuclein.
    Maor G; Rapaport D; Horowitz M
    Hum Mol Genet; 2019 Jun; 28(11):1768-1781. PubMed ID: 30615125
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation.
    Bae EJ; Yang NY; Lee C; Lee HJ; Kim S; Sardi SP; Lee SJ
    Exp Mol Med; 2015 Mar; 47(3):e153. PubMed ID: 25813221
    [TBL] [Abstract][Full Text] [Related]  

  • 27. GBA1 mutations: Prospects for exosomal biomarkers in α-synuclein pathologies.
    Johnson PH; Weinreb NJ; Cloyd JC; Tuite PJ; Kartha RV
    Mol Genet Metab; 2020 Feb; 129(2):35-46. PubMed ID: 31761523
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.
    Mahoney-Crane CL; Viswanathan M; Russell D; Curtiss RAC; Freire J; Bobba SS; Coyle SD; Kandebo M; Yao L; Wan BL; Hatcher NG; Smith SM; Marcus JN; Volpicelli-Daley LA
    J Neurosci; 2023 Jan; 43(3):501-521. PubMed ID: 36639889
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Mutant GBA1 expression and synucleinopathy risk: first insights from cellular and mouse models.
    Sardi SP; Singh P; Cheng SH; Shihabuddin LS; Schlossmacher MG
    Neurodegener Dis; 2012; 10(1-4):195-202. PubMed ID: 22327140
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Lysosomal functions and dysfunctions: Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease.
    Horowitz M; Braunstein H; Zimran A; Revel-Vilk S; Goker-Alpan O
    Adv Drug Deliv Rev; 2022 Aug; 187():114402. PubMed ID: 35764179
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels.
    Gündner AL; Duran-Pacheco G; Zimmermann S; Ruf I; Moors T; Baumann K; Jagasia R; van de Berg WDJ; Kremer T
    Neurobiol Dis; 2019 Jan; 121():205-213. PubMed ID: 30236861
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies.
    Chiasserini D; Paciotti S; Eusebi P; Persichetti E; Tasegian A; Kurzawa-Akanbi M; Chinnery PF; Morris CM; Calabresi P; Parnetti L; Beccari T
    Mol Neurodegener; 2015 Mar; 10():15. PubMed ID: 25881142
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
    Glajch KE; Moors TE; Chen Y; Bechade PA; Nam AY; Rajsombath MM; McCaffery TD; Dettmer U; Weihofen A; Hirst WD; Selkoe DJ; Nuber S
    Proc Natl Acad Sci U S A; 2021 Aug; 118(31):. PubMed ID: 34326260
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease.
    Magalhaes J; Gegg ME; Migdalska-Richards A; Doherty MK; Whitfield PD; Schapira AH
    Hum Mol Genet; 2016 Aug; 25(16):3432-3445. PubMed ID: 27378698
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model.
    Yang SY; Taanman JW; Gegg M; Schapira AHV
    Hum Mol Genet; 2022 Jul; 31(14):2396-2405. PubMed ID: 35179198
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Heat shock protein 70 reduces α-synuclein-induced predegenerative neuronal dystrophy in the α-synuclein viral gene transfer rat model of Parkinson's disease.
    Moloney TC; Hyland R; O'Toole D; Paucard A; Kirik D; O'Doherty A; Gorman AM; Dowd E
    CNS Neurosci Ther; 2014 Jan; 20(1):50-8. PubMed ID: 24279716
    [TBL] [Abstract][Full Text] [Related]  

  • 37. A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers.
    Yang SY; Beavan M; Chau KY; Taanman JW; Schapira AHV
    Stem Cell Reports; 2017 Mar; 8(3):728-742. PubMed ID: 28216145
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance.
    Blanz J; Saftig P
    J Neurochem; 2016 Oct; 139 Suppl 1():198-215. PubMed ID: 26860955
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Targeting the GBA1 pathway to slow Parkinson disease: Insights into clinical aspects, pathogenic mechanisms and new therapeutic avenues.
    Menozzi E; Toffoli M; Schapira AHV
    Pharmacol Ther; 2023 Jun; 246():108419. PubMed ID: 37080432
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Gaucher-related synucleinopathies: the examination of sporadic neurodegeneration from a rare (disease) angle.
    Sardi SP; Cheng SH; Shihabuddin LS
    Prog Neurobiol; 2015 Feb; 125():47-62. PubMed ID: 25573151
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 53.