325 related articles for article (PubMed ID: 26401053)
1. Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.
Li Y; Lu Y; Polak U; Lin K; Shen J; Farmer J; Seyer L; Bhalla AD; Rozwadowska N; Lynch DR; Butler JS; Napierala M
Hum Mol Genet; 2015 Dec; 24(24):6932-43. PubMed ID: 26401053
[TBL] [Abstract][Full Text] [Related]
2. Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming.
Polak U; Li Y; Butler JS; Napierala M
Stem Cells Dev; 2016 Dec; 25(23):1788-1800. PubMed ID: 27615158
[TBL] [Abstract][Full Text] [Related]
3. Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia.
Kim E; Napierala M; Dent SY
Nucleic Acids Res; 2011 Oct; 39(19):8366-77. PubMed ID: 21745819
[TBL] [Abstract][Full Text] [Related]
4. Altered nucleosome positioning at the transcription start site and deficient transcriptional initiation in Friedreich ataxia.
Chutake YK; Costello WN; Lam C; Bidichandani SI
J Biol Chem; 2014 May; 289(22):15194-202. PubMed ID: 24737321
[TBL] [Abstract][Full Text] [Related]
5. A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.
Lufino MM; Silva AM; Németh AH; Alegre-Abarrategui J; Russell AJ; Wade-Martins R
Hum Mol Genet; 2013 Dec; 22(25):5173-87. PubMed ID: 23943791
[TBL] [Abstract][Full Text] [Related]
6. Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3.
Chan PK; Torres R; Yandim C; Law PP; Khadayate S; Mauri M; Grosan C; Chapman-Rothe N; Giunti P; Pook M; Festenstein R
Hum Mol Genet; 2013 Jul; 22(13):2662-75. PubMed ID: 23474817
[TBL] [Abstract][Full Text] [Related]
7. Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells.
Silva AM; Brown JM; Buckle VJ; Wade-Martins R; Lufino MM
Hum Mol Genet; 2015 Jun; 24(12):3457-71. PubMed ID: 25814655
[TBL] [Abstract][Full Text] [Related]
8. The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues.
Al-Mahdawi S; Pinto RM; Ismail O; Varshney D; Lymperi S; Sandi C; Trabzuni D; Pook M
Hum Mol Genet; 2008 Mar; 17(5):735-46. PubMed ID: 18045775
[TBL] [Abstract][Full Text] [Related]
9. A novel GAA-repeat-expansion-based mouse model of Friedreich's ataxia.
Anjomani Virmouni S; Ezzatizadeh V; Sandi C; Sandi M; Al-Mahdawi S; Chutake Y; Pook MA
Dis Model Mech; 2015 Mar; 8(3):225-35. PubMed ID: 25681319
[TBL] [Abstract][Full Text] [Related]
10. Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation.
Punga T; Bühler M
EMBO Mol Med; 2010 Apr; 2(4):120-9. PubMed ID: 20373285
[TBL] [Abstract][Full Text] [Related]
11. A Comprehensive Transcriptome Analysis Identifies FXN and BDNF as Novel Targets of miRNAs in Friedreich's Ataxia Patients.
Misiorek JO; Schreiber AM; Urbanek-Trzeciak MO; Jazurek-Ciesiołka M; Hauser LA; Lynch DR; Napierala JS; Napierala M
Mol Neurobiol; 2020 Jun; 57(6):2639-2653. PubMed ID: 32291635
[TBL] [Abstract][Full Text] [Related]
12. Friedreich's ataxia--a case of aberrant transcription termination?
Butler JS; Napierala M
Transcription; 2015; 6(2):33-6. PubMed ID: 25831023
[TBL] [Abstract][Full Text] [Related]
13. Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells.
Gerhardt J; Bhalla AD; Butler JS; Puckett JW; Dervan PB; Rosenwaks Z; Napierala M
Cell Rep; 2016 Aug; 16(5):1218-1227. PubMed ID: 27425605
[TBL] [Abstract][Full Text] [Related]
14. Compound heterozygosity for an expanded (GAA) and a (GAAGGA) repeat at FXN locus: from a diagnostic pitfall to potential clues to the pathogenesis of Friedreich ataxia.
Santoro M; Perna A; La Rosa P; Petrillo S; Piemonte F; Rossi S; Riso V; Nicoletti TF; Modoni A; Pomponi MG; Chiurazzi P; Silvestri G
Neurogenetics; 2020 Oct; 21(4):279-287. PubMed ID: 32638185
[TBL] [Abstract][Full Text] [Related]
15. Premature transcription termination at the expanded GAA repeats and aberrant alternative polyadenylation contributes to the Frataxin transcriptional deficit in Friedreich's ataxia.
Li Y; Li J; Wang J; Zhang S; Giles K; Prakash TP; Rigo F; Napierala JS; Napierala M
Hum Mol Genet; 2022 Oct; 31(20):3539-3557. PubMed ID: 35708503
[TBL] [Abstract][Full Text] [Related]
16. Comprehensive analysis of gene expression patterns in Friedreich's ataxia fibroblasts by RNA sequencing reveals altered levels of protein synthesis factors and solute carriers.
Napierala JS; Li Y; Lu Y; Lin K; Hauser LA; Lynch DR; Napierala M
Dis Model Mech; 2017 Nov; 10(11):1353-1369. PubMed ID: 29125828
[TBL] [Abstract][Full Text] [Related]
17. Long intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia.
Soragni E; Herman D; Dent SY; Gottesfeld JM; Wells RD; Napierala M
Nucleic Acids Res; 2008 Nov; 36(19):6056-65. PubMed ID: 18820300
[TBL] [Abstract][Full Text] [Related]
18. Somatic instability of the expanded GAA repeats in Friedreich's ataxia.
Long A; Napierala JS; Polak U; Hauser L; Koeppen AH; Lynch DR; Napierala M
PLoS One; 2017; 12(12):e0189990. PubMed ID: 29261783
[TBL] [Abstract][Full Text] [Related]
19. Cis-silencing of PIP5K1B evidenced in Friedreich's ataxia patient cells results in cytoskeleton anomalies.
Bayot A; Reichman S; Lebon S; Csaba Z; Aubry L; Sterkers G; Husson I; Rak M; Rustin P
Hum Mol Genet; 2013 Jul; 22(14):2894-904. PubMed ID: 23552101
[TBL] [Abstract][Full Text] [Related]
20. The Regulation of the Disease-Causing Gene
Dong YN; Mercado-Ayón E; Coulman J; Flatley L; Ngaba LV; Adeshina MW; Lynch DR
Cells; 2024 Jun; 13(12):. PubMed ID: 38920668
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
