BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

566 related articles for article (PubMed ID: 26402604)

  • 1. Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS.
    Tran H; Almeida S; Moore J; Gendron TF; Chalasani U; Lu Y; Du X; Nickerson JA; Petrucelli L; Weng Z; Gao FB
    Neuron; 2015 Sep; 87(6):1207-1214. PubMed ID: 26402604
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.
    Moens TG; Mizielinska S; Niccoli T; Mitchell JS; Thoeng A; Ridler CE; Grönke S; Esser J; Heslegrave A; Zetterberg H; Partridge L; Isaacs AM
    Acta Neuropathol; 2018 Mar; 135(3):445-457. PubMed ID: 29380049
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Insights into C9ORF72-Related ALS/FTD from Drosophila and iPSC Models.
    Yuva-Aydemir Y; Almeida S; Gao FB
    Trends Neurosci; 2018 Jul; 41(7):457-469. PubMed ID: 29729808
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.
    Wen X; Tan W; Westergard T; Krishnamurthy K; Markandaiah SS; Shi Y; Lin S; Shneider NA; Monaghan J; Pandey UB; Pasinelli P; Ichida JK; Trotti D
    Neuron; 2014 Dec; 84(6):1213-25. PubMed ID: 25521377
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.
    Wen X; Westergard T; Pasinelli P; Trotti D
    Neurosci Lett; 2017 Jan; 636():16-26. PubMed ID: 27619540
    [TBL] [Abstract][Full Text] [Related]  

  • 6. RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3.
    Ramesh N; Daley EL; Gleixner AM; Mann JR; Kour S; Mawrie D; Anderson EN; Kofler J; Donnelly CJ; Kiskinis E; Pandey UB
    Acta Neuropathol Commun; 2020 Oct; 8(1):177. PubMed ID: 33129345
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Reduced autophagy upon C9ORF72 loss synergizes with dipeptide repeat protein toxicity in G4C2 repeat expansion disorders.
    Boivin M; Pfister V; Gaucherot A; Ruffenach F; Negroni L; Sellier C; Charlet-Berguerand N
    EMBO J; 2020 Feb; 39(4):e100574. PubMed ID: 31930538
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD.
    Yuva-Aydemir Y; Almeida S; Krishnan G; Gendron TF; Gao FB
    Nat Commun; 2019 Nov; 10(1):5466. PubMed ID: 31784536
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD.
    Taminato T; Takeuchi T; Ueyama M; Mori K; Ikeda M; Mochizuki H; Nagai Y
    Hum Mol Genet; 2023 May; 32(10):1673-1682. PubMed ID: 36611007
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD.
    He F; Flores BN; Krans A; Frazer M; Natla S; Niraula S; Adefioye O; Barmada SJ; Todd PK
    Acta Neuropathol Commun; 2020 Aug; 8(1):122. PubMed ID: 32753055
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity.
    Bennett CL; Dastidar S; Arnold FJ; McKinstry SU; Stockford C; Freibaum BD; Sopher BL; Wu M; Seidner G; Joiner W; Taylor JP; West RJH; La Spada AR
    Acta Neuropathol Commun; 2023 Oct; 11(1):164. PubMed ID: 37845749
    [TBL] [Abstract][Full Text] [Related]  

  • 12. RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.
    Zu T; Liu Y; Bañez-Coronel M; Reid T; Pletnikova O; Lewis J; Miller TM; Harms MB; Falchook AE; Subramony SH; Ostrow LW; Rothstein JD; Troncoso JC; Ranum LP
    Proc Natl Acad Sci U S A; 2013 Dec; 110(51):E4968-77. PubMed ID: 24248382
    [TBL] [Abstract][Full Text] [Related]  

  • 13. C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
    Licata NV; Cristofani R; Salomonsson S; Wilson KM; Kempthorne L; Vaizoglu D; D'Agostino VG; Pollini D; Loffredo R; Pancher M; Adami V; Bellosta P; Ratti A; Viero G; Quattrone A; Isaacs AM; Poletti A; Provenzani A
    EMBO J; 2022 Jan; 41(1):e105026. PubMed ID: 34791698
    [TBL] [Abstract][Full Text] [Related]  

  • 14. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport.
    Freibaum BD; Lu Y; Lopez-Gonzalez R; Kim NC; Almeida S; Lee KH; Badders N; Valentine M; Miller BL; Wong PC; Petrucelli L; Kim HJ; Gao FB; Taylor JP
    Nature; 2015 Sep; 525(7567):129-33. PubMed ID: 26308899
    [TBL] [Abstract][Full Text] [Related]  

  • 15. DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD.
    Fu X; Zhang Z; Hayes LR; Wright N; Asbury J; Li S; Ye Y; Sun S
    Exp Neurol; 2024 Jun; 376():114768. PubMed ID: 38556190
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration.
    Solomon DA; Stepto A; Au WH; Adachi Y; Diaper DC; Hall R; Rekhi A; Boudi A; Tziortzouda P; Lee YB; Smith B; Bridi JC; Spinelli G; Dearlove J; Humphrey DM; Gallo JM; Troakes C; Fanto M; Soller M; Rogelj B; Parsons RB; Shaw CE; Hortobágyi T; Hirth F
    Brain; 2018 Oct; 141(10):2908-2924. PubMed ID: 30239641
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy.
    Chew J; Cook C; Gendron TF; Jansen-West K; Del Rosso G; Daughrity LM; Castanedes-Casey M; Kurti A; Stankowski JN; Disney MD; Rothstein JD; Dickson DW; Fryer JD; Zhang YJ; Petrucelli L
    Mol Neurodegener; 2019 Feb; 14(1):9. PubMed ID: 30767771
    [TBL] [Abstract][Full Text] [Related]  

  • 18. BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model.
    Quezada E; Cappelli C; Diaz I; Jury N; Wightman N; Brown RH; Montecino M; van Zundert B
    Clin Epigenetics; 2021 Mar; 13(1):56. PubMed ID: 33726839
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G
    Czuppa M; Dhingra A; Zhou Q; Schludi C; König L; Scharf E; Farny D; Dalmia A; Täger J; Castillo-Lizardo M; Katona E; Mori K; Aumer T; Schelter F; Müller M; Carell T; Kalliokoski T; Messinger J; Rizzu P; Heutink P; Edbauer D
    Cell Rep; 2022 Jun; 39(10):110913. PubMed ID: 35675776
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nuclear RNA foci from
    Bajc Česnik A; Darovic S; Prpar Mihevc S; Štalekar M; Malnar M; Motaln H; Lee YB; Mazej J; Pohleven J; Grosch M; Modic M; Fonovič M; Turk B; Drukker M; Shaw CE; Rogelj B
    J Cell Sci; 2019 Mar; 132(5):. PubMed ID: 30745340
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 29.