BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

665 related articles for article (PubMed ID: 26433932)

  • 1. APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.
    Maulik M; Peake K; Chung J; Wang Y; Vance JE; Kar S
    Hum Mol Genet; 2015 Dec; 24(24):7132-50. PubMed ID: 26433932
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Effects of Extracellular Serum Concentration on APP Processing in Npc1-Deficient APP-Overexpressing N2a Cells.
    Maulik M; Vergote D; Phukan G; Chung J; Thinakaran G; Kar S
    Mol Neurobiol; 2018 Jul; 55(7):5757-5766. PubMed ID: 29052144
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin.
    Maulik M; Ghoshal B; Kim J; Wang Y; Yang J; Westaway D; Kar S
    Hum Mol Genet; 2012 Nov; 21(22):4857-75. PubMed ID: 22869680
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins.
    Cermak S; Kosicek M; Mladenovic-Djordjevic A; Smiljanic K; Kanazir S; Hecimovic S
    PLoS One; 2016; 11(11):e0167428. PubMed ID: 27902765
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells.
    Chung J; Phukan G; Vergote D; Mohamed A; Maulik M; Stahn M; Andrew RJ; Thinakaran G; Posse de Chaves E; Kar S
    Mol Cell Biol; 2018 Jun; 38(11):. PubMed ID: 29530923
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Macroautophagy is not directly involved in the metabolism of amyloid precursor protein.
    Boland B; Smith DA; Mooney D; Jung SS; Walsh DM; Platt FM
    J Biol Chem; 2010 Nov; 285(48):37415-26. PubMed ID: 20864542
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Alterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 protein.
    Maulik M; Thinakaran G; Kar S
    PLoS One; 2013; 8(1):e54605. PubMed ID: 23382922
    [TBL] [Abstract][Full Text] [Related]  

  • 8. TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons.
    Yamamoto F; Taniguchi K; Mamada N; Tamaoka A; Kametani F; Lakshmana MK; Araki W
    Neuroscience; 2019 Mar; 402():11-22. PubMed ID: 30677488
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.
    Xiao Q; Yan P; Ma X; Liu H; Perez R; Zhu A; Gonzales E; Tripoli DL; Czerniewski L; Ballabio A; Cirrito JR; Diwan A; Lee JM
    J Neurosci; 2015 Sep; 35(35):12137-51. PubMed ID: 26338325
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells.
    Malnar M; Kosicek M; Lisica A; Posavec M; Krolo A; Njavro J; Omerbasic D; Tahirovic S; Hecimovic S
    Biochim Biophys Acta; 2012 Aug; 1822(8):1270-83. PubMed ID: 22551668
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of cholesterol transport inhibitor U18666A on APP metabolism in rat primary astrocytes.
    Yang H; Wang Y; Kar S
    Glia; 2017 Nov; 65(11):1728-1743. PubMed ID: 28722194
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.
    Burns M; Gaynor K; Olm V; Mercken M; LaFrancois J; Wang L; Mathews PM; Noble W; Matsuoka Y; Duff K
    J Neurosci; 2003 Jul; 23(13):5645-9. PubMed ID: 12843267
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Neurons die with heightened but functional macro- and chaperone mediated autophagy upon increased amyloid-ß induced toxicity with region-specific protection in prolonged intermittent fasting.
    Ntsapi CM; Loos B
    Exp Cell Res; 2021 Nov; 408(2):112840. PubMed ID: 34624324
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities.
    Jin LW; Shie FS; Maezawa I; Vincent I; Bird T
    Am J Pathol; 2004 Mar; 164(3):975-85. PubMed ID: 14982851
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains.
    Vaillant-Beuchot L; Mary A; Pardossi-Piquard R; Bourgeois A; Lauritzen I; Eysert F; Kinoshita PF; Cazareth J; Badot C; Fragaki K; Bussiere R; Martin C; Mary R; Bauer C; Pagnotta S; Paquis-Flucklinger V; Buée-Scherrer V; Buée L; Lacas-Gervais S; Checler F; Chami M
    Acta Neuropathol; 2021 Jan; 141(1):39-65. PubMed ID: 33079262
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.
    Kwart D; Gregg A; Scheckel C; Murphy EA; Paquet D; Duffield M; Fak J; Olsen O; Darnell RB; Tessier-Lavigne M
    Neuron; 2019 Oct; 104(2):256-270.e5. PubMed ID: 31416668
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 18. α-secretase cleaved amyloid precursor protein (APP) accumulates in cholinergic dystrophic neurites in normal, aged hippocampus.
    Yoon SY; Choi JU; Cho MH; Yang KM; Ha H; Chung IJ; Cho GS; Kim DH
    Neuropathol Appl Neurobiol; 2013 Dec; 39(7):800-16. PubMed ID: 23414335
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.
    Bretou M; Sannerud R; Escamilla-Ayala A; Leroy T; Vrancx C; Van Acker ZP; Perdok A; Vermeire W; Vorsters I; Van Keymolen S; Maxson M; Pavie B; Wierda K; Eskelinen EL; Annaert W
    Dev Cell; 2024 Jun; 59(12):1571-1592.e9. PubMed ID: 38626765
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability.
    Wang Y; Buggia-Prévot V; Zavorka ME; Bleackley RC; MacDonald RG; Thinakaran G; Kar S
    Mol Cell Biol; 2015 Jul; 35(14):2368-84. PubMed ID: 25939386
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 34.