217 related articles for article (PubMed ID: 26443011)
1. Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking.
Rettenmaier TJ; Fan H; Karpiak J; Doak A; Sali A; Shoichet BK; Wells JA
J Med Chem; 2015 Oct; 58(20):8285-8291. PubMed ID: 26443011
[TBL] [Abstract][Full Text] [Related]
2. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
Rettenmaier TJ; Sadowsky JD; Thomsen ND; Chen SC; Doak AK; Arkin MR; Wells JA
Proc Natl Acad Sci U S A; 2014 Dec; 111(52):18590-5. PubMed ID: 25518860
[TBL] [Abstract][Full Text] [Related]
3. Discovery of SBF1 as an allosteric inhibitor targeting the PIF-pocket of 3-phosphoinositide-dependent protein kinase-1.
Liu W; Li P; Mei Y
J Mol Model; 2019 Jun; 25(7):187. PubMed ID: 31197600
[TBL] [Abstract][Full Text] [Related]
4. Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Schulze JO; Saladino G; Busschots K; Neimanis S; Süß E; Odadzic D; Zeuzem S; Hindie V; Herbrand AK; Lisa MN; Alzari PM; Gervasio FL; Biondi RM
Cell Chem Biol; 2016 Oct; 23(10):1193-1205. PubMed ID: 27693059
[TBL] [Abstract][Full Text] [Related]
5. 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.
Wilhelm A; Lopez-Garcia LA; Busschots K; Fröhner W; Maurer F; Boettcher S; Zhang H; Schulze JO; Biondi RM; Engel M
J Med Chem; 2012 Nov; 55(22):9817-30. PubMed ID: 23106316
[TBL] [Abstract][Full Text] [Related]
6. Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H-15N TROSY experiments.
Stockman BJ; Kothe M; Kohls D; Weibley L; Connolly BJ; Sheils AL; Cao Q; Cheng AC; Yang L; Kamath AV; Ding YH; Charlton ME
Chem Biol Drug Des; 2009 Feb; 73(2):179-88. PubMed ID: 19207420
[TBL] [Abstract][Full Text] [Related]
7. High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.
Biondi RM; Komander D; Thomas CC; Lizcano JM; Deak M; Alessi DR; van Aalten DM
EMBO J; 2002 Aug; 21(16):4219-28. PubMed ID: 12169624
[TBL] [Abstract][Full Text] [Related]
8. The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1.
Xu X; Chen Y; Fu Q; Ni D; Zhang J; Li X; Lu S
J Enzyme Inhib Med Chem; 2019 Dec; 34(1):361-374. PubMed ID: 30734603
[TBL] [Abstract][Full Text] [Related]
9. Structure-based drug design and molecular dynamics studies of an allosteric modulator targeting the protein-protein interaction site of PDK1.
Kailasam Natesan V; Kuppannagounder Pitchaimuthu E
J Mol Model; 2024 Jan; 30(2):51. PubMed ID: 38277080
[TBL] [Abstract][Full Text] [Related]
10. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.
Busschots K; Lopez-Garcia LA; Lammi C; Stroba A; Zeuzem S; Piiper A; Alzari PM; Neimanis S; Arencibia JM; Engel M; Schulze JO; Biondi RM
Chem Biol; 2012 Sep; 19(9):1152-63. PubMed ID: 22999883
[TBL] [Abstract][Full Text] [Related]
11. Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
Sadowsky JD; Burlingame MA; Wolan DW; McClendon CL; Jacobson MP; Wells JA
Proc Natl Acad Sci U S A; 2011 Apr; 108(15):6056-61. PubMed ID: 21430264
[TBL] [Abstract][Full Text] [Related]
12. Structure-based discovery of the first allosteric inhibitors of cyclin-dependent kinase 2.
Rastelli G; Anighoro A; Chripkova M; Carrassa L; Broggini M
Cell Cycle; 2014; 13(14):2296-305. PubMed ID: 24911186
[TBL] [Abstract][Full Text] [Related]
13. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.
Hindie V; Stroba A; Zhang H; Lopez-Garcia LA; Idrissova L; Zeuzem S; Hirschberg D; Schaeffer F; Jørgensen TJ; Engel M; Alzari PM; Biondi RM
Nat Chem Biol; 2009 Oct; 5(10):758-64. PubMed ID: 19718043
[TBL] [Abstract][Full Text] [Related]
14. PDK1 disruptors and modulators: a patent review.
Hossen MJ; Kim SC; Yang S; Kim HG; Jeong D; Yi YS; Sung NY; Lee JO; Kim JH; Cho JY
Expert Opin Ther Pat; 2015 May; 25(5):513-37. PubMed ID: 25684022
[TBL] [Abstract][Full Text] [Related]
15. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.
Stroba A; Schaeffer F; Hindie V; Lopez-Garcia L; Adrian I; Fröhner W; Hartmann RW; Biondi RM; Engel M
J Med Chem; 2009 Aug; 52(15):4683-93. PubMed ID: 19606904
[TBL] [Abstract][Full Text] [Related]
16. Use of a fluorescent ATP analog to probe the allosteric conformational change in the active site of the protein kinase PDK1.
Hindie V; Lopez-Garcia LA; Biondi RM
Methods Mol Biol; 2012; 928():133-41. PubMed ID: 22956138
[TBL] [Abstract][Full Text] [Related]
17. Discovery of novel tubulin inhibitors via structure-based hierarchical virtual screening.
Cao R; Liu M; Yin M; Liu Q; Wang Y; Huang N
J Chem Inf Model; 2012 Oct; 52(10):2730-40. PubMed ID: 22992059
[TBL] [Abstract][Full Text] [Related]
18. Probing an Allosteric Pocket of CDK2 with Small Molecules.
Christodoulou MS; Caporuscio F; Restelli V; Carlino L; Cannazza G; Costanzi E; Citti C; Lo Presti L; Pisani P; Battistutta R; Broggini M; Passarella D; Rastelli G
ChemMedChem; 2017 Jan; 12(1):33-41. PubMed ID: 27860401
[TBL] [Abstract][Full Text] [Related]
19. Homology modeling, docking, and molecular dynamics simulation of the receptor GALR2 and its interactions with galanin and a positive allosteric modulator.
Hui WQ; Cheng Q; Liu TY; Ouyang Q
J Mol Model; 2016 Apr; 22(4):90. PubMed ID: 27021209
[TBL] [Abstract][Full Text] [Related]
20. Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening.
Zhou Q; Guo W; Dai A; Cai X; Vass M; de Graaf C; Shui W; Zhao S; Yang D; Wang MW
Biomolecules; 2021 Jun; 11(7):. PubMed ID: 34201418
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
