98 related articles for article (PubMed ID: 26452398)
1. Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead.
Kikumori M; Yanagita RC; Tokuda H; Suenaga K; Nagai H; Irie K
Biosci Biotechnol Biochem; 2016; 80(2):221-31. PubMed ID: 26452398
[TBL] [Abstract][Full Text] [Related]
2. Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.
Kikumori M; Yanagita RC; Tokuda H; Suzuki N; Nagai H; Suenaga K; Irie K
J Med Chem; 2012 Jun; 55(11):5614-26. PubMed ID: 22625994
[TBL] [Abstract][Full Text] [Related]
3. Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines.
Hanaki Y; Shikata Y; Kikumori M; Hotta N; Imoto M; Irie K
Biochem Biophys Res Commun; 2018 Jan; 495(1):438-445. PubMed ID: 29129688
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities.
Hanaki Y; Yanagita RC; Sugahara T; Aida M; Tokuda H; Suzuki N; Irie K
Biosci Biotechnol Biochem; 2015; 79(6):888-95. PubMed ID: 25612633
[TBL] [Abstract][Full Text] [Related]
5. Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.
Hanaki Y; Kikumori M; Tokuda H; Okamura M; Dan S; Adachi N; Saito N; Yanagita RC; Irie K
Molecules; 2017 Apr; 22(4):. PubMed ID: 28406454
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin.
Nakagawa Y; Kikumori M; Yanagita RC; Murakami A; Tokuda H; Nagai H; Irie K
Biosci Biotechnol Biochem; 2011; 75(6):1167-73. PubMed ID: 21670518
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/π interaction.
Kobayashi T; Yanagita RC; Irie K
Bioorg Med Chem Lett; 2020 Dec; 30(24):127657. PubMed ID: 33130291
[TBL] [Abstract][Full Text] [Related]
8. Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities.
Gonda A; Takada K; Yanagita RC; Dan S; Irie K
Biosci Biotechnol Biochem; 2021 Jan; 85(1):168-180. PubMed ID: 33577665
[TBL] [Abstract][Full Text] [Related]
9. Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.
Kamachi H; Tanaka K; Yanagita RC; Murakami A; Murakami K; Tokuda H; Suzuki N; Nakagawa Y; Irie K
Bioorg Med Chem; 2013 May; 21(10):2695-702. PubMed ID: 23582444
[TBL] [Abstract][Full Text] [Related]
10. Invivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest.
Hanaki Y; Shikata Y; Kikumori M; Okamura M; Dan S; Imoto M; Irie K
Biochem Biophys Res Commun; 2023 Oct; 675():19-25. PubMed ID: 37437496
[TBL] [Abstract][Full Text] [Related]
11. Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.
Yanagita RC; Kamachi H; Kikumori M; Tokuda H; Suzuki N; Suenaga K; Nagai H; Irie K
Bioorg Med Chem Lett; 2013 Aug; 23(15):4319-23. PubMed ID: 23803585
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.
Irie K; Yanagita RC
Chem Rec; 2014 Apr; 14(2):251-67. PubMed ID: 24677503
[TBL] [Abstract][Full Text] [Related]
13. A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.
Nakagawa Y; Yanagita RC; Hamada N; Murakami A; Takahashi H; Saito N; Nagai H; Irie K
J Am Chem Soc; 2009 Jun; 131(22):7573-9. PubMed ID: 19449873
[TBL] [Abstract][Full Text] [Related]
14. A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities.
Sekido T; Yamamoto K; Yanagita RC; Kawamani Y; Hanaki Y; Irie K
Bioorg Med Chem; 2022 Nov; 73():116988. PubMed ID: 36113282
[TBL] [Abstract][Full Text] [Related]
15. Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.
Yanagita RC; Kamachi H; Tanaka K; Murakami A; Nakagawa Y; Tokuda H; Nagai H; Irie K
Bioorg Med Chem Lett; 2010 Oct; 20(20):6064-6. PubMed ID: 20817520
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis, and biological activity of a synthetically accessible analog of aplysiatoxin with an (R)-(-)-carvone-based conformation-controlling unit.
Suzuki Y; Moritoki K; Kajiwara M; Yanagita RC; Kawanami Y; Hanaki Y; Irie K
Biosci Biotechnol Biochem; 2022 Jul; 86(8):1013-1023. PubMed ID: 35648459
[TBL] [Abstract][Full Text] [Related]
17. The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters.
Fujiki H; Suganuma M; Nakayasu M; Hoshino H; Moore RE; Sugimura T
Gan; 1982 Jun; 73(3):495-7. PubMed ID: 7129014
[TBL] [Abstract][Full Text] [Related]
18. Gamma-lactones alpha,beta- and beta,gamma-fused to carbocycles as novel antiproliferative drugs.
León LG; Machín RP; Rodríguez CM; Ravelo JL; Martín VS; Padrón JM
Bioorg Med Chem Lett; 2008 Oct; 18(19):5171-3. PubMed ID: 18789684
[TBL] [Abstract][Full Text] [Related]
19. 20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines.
Koike M; Koshizuka K; Kawabata H; Yang R; Taub HE; Said J; Uskokovic M; Tsuruoka N; Koeffler HP
Anticancer Res; 1999; 19(3A):1689-97. PubMed ID: 10470102
[TBL] [Abstract][Full Text] [Related]
20. Comparative effects of aplysiatoxin, debromoaplysiatoxin, and teleocidin on receptor binding and phospholipid metabolism.
Horowitz AD; Fujiki H; Weinstein IB; Jeffrey A; Okin E; Moore RE; Sugimura T
Cancer Res; 1983 Apr; 43(4):1529-35. PubMed ID: 6299522
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
