411 related articles for article (PubMed ID: 26453300)
1. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
Lu S; Banerjee A; Jang H; Zhang J; Gaponenko V; Nussinov R
J Biol Chem; 2015 Nov; 290(48):28887-900. PubMed ID: 26453300
[TBL] [Abstract][Full Text] [Related]
2. The higher level of complexity of K-Ras4B activation at the membrane.
Jang H; Banerjee A; Chavan TS; Lu S; Zhang J; Gaponenko V; Nussinov R
FASEB J; 2016 Apr; 30(4):1643-55. PubMed ID: 26718888
[TBL] [Abstract][Full Text] [Related]
3. The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.
Lu S; Jang H; Nussinov R; Zhang J
Sci Rep; 2016 Feb; 6():21949. PubMed ID: 26902995
[TBL] [Abstract][Full Text] [Related]
4. Conformational Dynamics Allows Sampling of an "Active-like" State by Oncogenic K-Ras-GDP.
Grudzien P; Jang H; Leschinsky N; Nussinov R; Gaponenko V
J Mol Biol; 2022 Sep; 434(17):167695. PubMed ID: 35752212
[TBL] [Abstract][Full Text] [Related]
5. Markov State Models and Molecular Dynamics Simulations Reveal the Conformational Transition of the Intrinsically Disordered Hypervariable Region of K-Ras4B to the Ordered Conformation.
Zhang H; Ni D; Fan J; Li M; Zhang J; Hua C; Nussinov R; Lu S
J Chem Inf Model; 2022 Sep; 62(17):4222-4231. PubMed ID: 35994329
[TBL] [Abstract][Full Text] [Related]
6. High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
Chavan TS; Jang H; Khavrutskii L; Abraham SJ; Banerjee A; Freed BC; Johannessen L; Tarasov SG; Gaponenko V; Nussinov R; Tarasova NI
Biophys J; 2015 Dec; 109(12):2602-2613. PubMed ID: 26682817
[TBL] [Abstract][Full Text] [Related]
7. Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.
Jang H; Abraham SJ; Chavan TS; Hitchinson B; Khavrutskii L; Tarasova NI; Nussinov R; Gaponenko V
J Biol Chem; 2015 Apr; 290(15):9465-77. PubMed ID: 25713064
[TBL] [Abstract][Full Text] [Related]
8. Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Mazhab-Jafari MT; Marshall CB; Smith MJ; Gasmi-Seabrook GM; Stathopulos PB; Inagaki F; Kay LE; Neel BG; Ikura M
Proc Natl Acad Sci U S A; 2015 May; 112(21):6625-30. PubMed ID: 25941399
[TBL] [Abstract][Full Text] [Related]
9. The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.
Banerjee A; Jang H; Nussinov R; Gaponenko V
Curr Opin Struct Biol; 2016 Feb; 36():10-7. PubMed ID: 26709496
[TBL] [Abstract][Full Text] [Related]
10. Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling.
Dudas B; Merzel F; Jang H; Nussinov R; Perahia D; Balog E
Front Mol Biosci; 2020; 7():145. PubMed ID: 32754617
[TBL] [Abstract][Full Text] [Related]
11. Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
Jang H; Banerjee A; Chavan T; Gaponenko V; Nussinov R
J Biol Chem; 2017 Jul; 292(30):12544-12559. PubMed ID: 28623230
[TBL] [Abstract][Full Text] [Related]
12. Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences.
Chakrabarti M; Jang H; Nussinov R
J Phys Chem B; 2016 Feb; 120(4):667-79. PubMed ID: 26761128
[TBL] [Abstract][Full Text] [Related]
13. Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.
Muratcioglu S; Aydin C; Odabasi E; Ozdemir ES; Firat-Karalar EN; Jang H; Tsai CJ; Nussinov R; Kavakli IH; Gursoy A; Keskin O
J Mol Biol; 2020 Feb; 432(4):1199-1215. PubMed ID: 31931009
[TBL] [Abstract][Full Text] [Related]
14. Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.
Spoerner M; Hozsa C; Poetzl JA; Reiss K; Ganser P; Geyer M; Kalbitzer HR
J Biol Chem; 2010 Dec; 285(51):39768-78. PubMed ID: 20937837
[TBL] [Abstract][Full Text] [Related]
15. Electrostatic control of GTP and GDP binding in the oncoprotein p21ras.
Muegge I; Schweins T; Langen R; Warshel A
Structure; 1996 Apr; 4(4):475-89. PubMed ID: 8740369
[TBL] [Abstract][Full Text] [Related]
16. NMR
Sharma AK; Lee SJ; Rigby AC; Townson SA
Biomol NMR Assign; 2018 Oct; 12(2):269-272. PubMed ID: 29721757
[TBL] [Abstract][Full Text] [Related]
17. Guanine-nucleotide binding activity, interaction with GTPase-activating protein and solution conformation of the human c-Ha-Ras protein catalytic domain are retained upon deletion of C-terminal 18 amino acid residues.
Fujita-Yoshigaki J; Ito Y; Yamasaki K; Muto Y; Miyazawa T; Nishimura S; Yokoyama S
J Protein Chem; 1992 Dec; 11(6):731-9. PubMed ID: 1466766
[TBL] [Abstract][Full Text] [Related]
18. Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics.
Mello LV; van Aalten DM; Findlay JB
Protein Eng; 1997 Apr; 10(4):381-7. PubMed ID: 9194162
[TBL] [Abstract][Full Text] [Related]
19. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
Gentile DR; Rathinaswamy MK; Jenkins ML; Moss SM; Siempelkamp BD; Renslo AR; Burke JE; Shokat KM
Cell Chem Biol; 2017 Dec; 24(12):1455-1466.e14. PubMed ID: 29033317
[TBL] [Abstract][Full Text] [Related]
20. Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms.
Weise K; Kapoor S; Denter C; Nikolaus J; Opitz N; Koch S; Triola G; Herrmann A; Waldmann H; Winter R
J Am Chem Soc; 2011 Feb; 133(4):880-7. PubMed ID: 21141956
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]