BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

209 related articles for article (PubMed ID: 26456302)

  • 1. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas.
    Gruosso T; Garnier C; Abelanet S; Kieffer Y; Lemesre V; Bellanger D; Bieche I; Marangoni E; Sastre-Garau X; Mieulet V; Mechta-Grigoriou F
    Nat Commun; 2015 Oct; 6():8583. PubMed ID: 26456302
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Low Grade Serous Ovarian Carcinoma: from the molecular characterization to the best therapeutic strategy.
    Della Pepa C; Tonini G; Santini D; Losito S; Pisano C; Di Napoli M; Cecere SC; Gargiulo P; Pignata S
    Cancer Treat Rev; 2015 Feb; 41(2):136-43. PubMed ID: 25573350
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting the mitogen-activated protein kinase pathway in low-grade serous carcinoma of the ovary.
    McLachlan J; Gore M; Banerjee S
    Pharmacogenomics; 2016 Aug; 17(12):1353-63. PubMed ID: 27469379
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer.
    Grisham RN; Sylvester BE; Won H; McDermott G; DeLair D; Ramirez R; Yao Z; Shen R; Dao F; Bogomolniy F; Makker V; Sala E; Soumerai TE; Hyman DM; Socci ND; Viale A; Gershenson DM; Farley J; Levine DA; Rosen N; Berger MF; Spriggs DR; Aghajanian CA; Solit DB; Iyer G
    J Clin Oncol; 2015 Dec; 33(34):4099-105. PubMed ID: 26324360
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Registered Report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
    Sharma V; Young L; Cavadas M; Owen K;
    Elife; 2016 Mar; 5():. PubMed ID: 26999821
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Multiomics Characterization of Low-Grade Serous Ovarian Carcinoma Identifies Potential Biomarkers of MEK Inhibitor Sensitivity and Therapeutic Vulnerability.
    Shrestha R; Llaurado Fernandez M; Dawson A; Hoenisch J; Volik S; Lin YY; Anderson S; Kim H; Haegert AM; Colborne S; Wong NKY; McConeghy B; Bell RH; Brahmbhatt S; Lee CH; DiMattia GE; Le Bihan S; Morin GB; Collins CC; Carey MS
    Cancer Res; 2021 Apr; 81(7):1681-1694. PubMed ID: 33441310
    [TBL] [Abstract][Full Text] [Related]  

  • 7. γ-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway.
    Li Y; Wu T; Wang Y; Yang L; Hu C; Chen L; Wu S
    Gynecol Oncol; 2018 Apr; 149(1):163-172. PubMed ID: 29429592
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway overcomes cisplatin resistance in ovarian carcinoma cells.
    Nonaka M; Itamochi H; Kawaguchi W; Kudoh A; Sato S; Uegaki K; Naniwa J; Sato S; Shimada M; Oishi T; Terakawa N; Kigawa J; Harada T
    Int J Gynecol Cancer; 2012 Jul; 22(6):922-9. PubMed ID: 22672985
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer.
    Hew KE; Miller PC; El-Ashry D; Sun J; Besser AH; Ince TA; Gu M; Wei Z; Zhang G; Brafford P; Gao W; Lu Y; Mills GB; Slingerland JM; Simpkins F
    Clin Cancer Res; 2016 Feb; 22(4):935-47. PubMed ID: 26482043
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma.
    Kannan K; Coarfa C; Chao PW; Luo L; Wang Y; Brinegar AE; Hawkins SM; Milosavljevic A; Matzuk MM; Yen L
    Proc Natl Acad Sci U S A; 2015 Mar; 112(11):E1272-7. PubMed ID: 25733895
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of active mitogen-activated protein kinase in ovarian serous carcinomas.
    Hsu CY; Bristow R; Cha MS; Wang BG; Ho CL; Kurman RJ; Wang TL; Shih IeM
    Clin Cancer Res; 2004 Oct; 10(19):6432-6. PubMed ID: 15475429
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Selumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: an open-label, single-arm, phase 2 study.
    Farley J; Brady WE; Vathipadiekal V; Lankes HA; Coleman R; Morgan MA; Mannel R; Yamada SD; Mutch D; Rodgers WH; Birrer M; Gershenson DM
    Lancet Oncol; 2013 Feb; 14(2):134-40. PubMed ID: 23261356
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of Targetable Recurrent MAP3K8 Rearrangements in Melanomas Lacking Known Driver Mutations.
    Lehmann BD; Shaver TM; Johnson DB; Li Z; Gonzalez-Ericsson PI; Sánchez V; Shyr Y; Sanders ME; Pietenpol JA
    Mol Cancer Res; 2019 Sep; 17(9):1842-1853. PubMed ID: 31186280
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation.
    Kim K; Kim G; Kim JY; Yun HJ; Lim SC; Choi HS
    Carcinogenesis; 2014 Jun; 35(6):1352-61. PubMed ID: 24517997
    [TBL] [Abstract][Full Text] [Related]  

  • 15. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition.
    Gilmartin AG; Bleam MR; Groy A; Moss KG; Minthorn EA; Kulkarni SG; Rominger CM; Erskine S; Fisher KE; Yang J; Zappacosta F; Annan R; Sutton D; Laquerre SG
    Clin Cancer Res; 2011 Mar; 17(5):989-1000. PubMed ID: 21245089
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.
    Beinke S; Robinson MJ; Hugunin M; Ley SC
    Mol Cell Biol; 2004 Nov; 24(21):9658-67. PubMed ID: 15485931
    [TBL] [Abstract][Full Text] [Related]  

  • 17. microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways.
    Wei R; Yang Q; Han B; Li Y; Yao K; Yang X; Chen Z; Yang S; Zhou J; Li M; Yu H; Yu M; Cui Q
    Oncotarget; 2017 Mar; 8(10):16633-16641. PubMed ID: 28186962
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Preclinical efficacy of RAF/MEK clamp avutometinib in combination with FAK inhibition in low grade serous ovarian cancer.
    McNamara B; Demirkiran C; Hartwich TMP; Bellone S; Manavella D; Mutlu L; Greenman M; Zipponi M; Yang-Hartwich Y; Yang K; Ratner E; Schwartz PE; Coma S; Pachter JA; Santin AD
    Gynecol Oncol; 2024 Apr; 183():133-140. PubMed ID: 38493021
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells.
    Kannan Y; Li Y; Coomes SM; Okoye IS; Pelly VS; Sriskantharajah S; Gückel E; Webb L; Czieso S; Nikolov N; MacDonald AS; Ley SC; Wilson MS
    J Allergy Clin Immunol; 2017 Feb; 139(2):655-666.e7. PubMed ID: 27484038
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cot protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells.
    Hagemann D; Troppmair J; Rapp UR
    Oncogene; 1999 Feb; 18(7):1391-400. PubMed ID: 10050876
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.