163 related articles for article (PubMed ID: 26457742)
1. Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors.
Kim HS; Hong M; Lee SC; Lee HY; Suh YG; Oh DC; Seo JH; Choi H; Kim JY; Kim KW; Kim JH; Kim J; Kim YM; Park SJ; Park HJ; Lee J
Eur J Med Chem; 2015 Nov; 104():157-64. PubMed ID: 26457742
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors.
Kim HS; Hong M; Ann J; Yoon S; Nguyen CT; Lee SC; Lee HY; Suh YG; Seo JH; Choi H; Kim JY; Kim KW; Kim J; Kim YM; Park SJ; Park HJ; Lee J
Bioorg Med Chem; 2016 Nov; 24(22):6082-6093. PubMed ID: 27745993
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.
Chang DJ; An H; Kim KS; Kim HH; Jung J; Lee JM; Kim NJ; Han YT; Yun H; Lee S; Lee G; Lee S; Lee JS; Cha JH; Park JH; Park JW; Lee SC; Kim SG; Kim JH; Lee HY; Kim KW; Suh YG
J Med Chem; 2012 Dec; 55(24):10863-84. PubMed ID: 23186287
[TBL] [Abstract][Full Text] [Related]
4. Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents.
Kim HS; Hoang VH; Hong M; Chul Kim K; Ann J; Nguyen CT; Seo JH; Choi H; Yong Kim J; Kim KW; Sub Byun W; Lee S; Lee S; Suh YG; Chen J; Park HJ; Cho TM; Kim JY; Seo JH; Lee J
Bioorg Med Chem; 2019 Apr; 27(7):1370-1381. PubMed ID: 30827868
[TBL] [Abstract][Full Text] [Related]
5. Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha.
Oh SH; Woo JK; Jin Q; Kang HJ; Jeong JW; Kim KW; Hong WK; Lee HY
Int J Cancer; 2008 Jan; 122(1):5-14. PubMed ID: 17764071
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and Evaluation of a Novel Deguelin Derivative, L80, which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90.
Lee SC; Min HY; Choi H; Kim HS; Kim KC; Park SJ; Seong MA; Seo JH; Park HJ; Suh YG; Kim KW; Hong HS; Kim H; Lee MY; Lee J; Lee HY
Mol Pharmacol; 2015 Aug; 88(2):245-55. PubMed ID: 25976766
[TBL] [Abstract][Full Text] [Related]
7. Novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitor: synthesis, anti-invasive and anti-angiogenic properties.
Wang L; Chen G; Lu X; Wang S; Han S; Li Y; Ping G; Jiang X; Li H; Yang J; Wu C
Eur J Med Chem; 2015 Jan; 89():88-97. PubMed ID: 25462229
[TBL] [Abstract][Full Text] [Related]
8. Structural basis for depletion of heat shock protein 90 client proteins by deguelin.
Oh SH; Woo JK; Yazici YD; Myers JN; Kim WY; Jin Q; Hong SS; Park HJ; Suh YG; Kim KW; Hong WK; Lee HY
J Natl Cancer Inst; 2007 Jun; 99(12):949-61. PubMed ID: 17565155
[TBL] [Abstract][Full Text] [Related]
9. Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis.
DeNiro M; Alsmadi O; Al-Mohanna F
Exp Eye Res; 2009 Nov; 89(5):700-17. PubMed ID: 19580810
[TBL] [Abstract][Full Text] [Related]
10. Discovery of a simplified deguelin analog as an HSP90 C-terminal inhibitor for HER2-positive breast cancer.
Nguyen CT; Thanh La M; Ann J; Nam G; Park HJ; Min Park J; Kim YJ; Young Kim J; Hong Seo J; Lee J
Bioorg Med Chem Lett; 2021 Aug; 45():128134. PubMed ID: 34044120
[TBL] [Abstract][Full Text] [Related]
11. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues.
Xia Y; Jin Y; Kaur N; Choi Y; Lee K
Eur J Med Chem; 2011 Jun; 46(6):2386-96. PubMed ID: 21481991
[TBL] [Abstract][Full Text] [Related]
12. Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis.
Lee JH; Lee DH; Lee HS; Choi JS; Kim KW; Hong SS
Oncol Rep; 2008 Jul; 20(1):129-34. PubMed ID: 18575727
[TBL] [Abstract][Full Text] [Related]
13. Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy.
An H; Lee S; Lee JM; Jo DH; Kim J; Jeong YS; Heo MJ; Cho CS; Choi H; Seo JH; Hwang S; Lim J; Kim T; Jun HO; Sim J; Lim C; Hur J; Ahn J; Kim HS; Seo SY; Na Y; Kim SH; Lee J; Lee J; Chung SJ; Kim YM; Kim KW; Kim SG; Kim JH; Suh YG
J Med Chem; 2018 Oct; 61(20):9266-9286. PubMed ID: 30252468
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.
Yao H; Xu F; Wang G; Xie S; Li W; Yao H; Ma C; Zhu Z; Xu J; Xu S
Eur J Med Chem; 2019 Apr; 167():485-498. PubMed ID: 30784881
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and biological evaluation of novel benzylidene-succinimide derivatives as noncytotoxic antiangiogenic inhibitors with anticolorectal cancer activity in vivo.
Luo K; Bao Y; Liu F; Xiao C; Li K; Zhang C; Huang R; Lin J; Zhang J; Jin Y
Eur J Med Chem; 2019 Oct; 179():805-827. PubMed ID: 31295714
[TBL] [Abstract][Full Text] [Related]
16. Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment.
Narise K; Okuda K; Enomoto Y; Hirayama T; Nagasawa H
Drug Des Devel Ther; 2014; 8():701-17. PubMed ID: 24944508
[TBL] [Abstract][Full Text] [Related]
17. A group of novel HIF-1α inhibitors, glyceollins, blocks HIF-1α synthesis and decreases its stability via inhibition of the PI3K/AKT/mTOR pathway and Hsp90 binding.
Lee SH; Jee JG; Bae JS; Liu KH; Lee YM
J Cell Physiol; 2015 Apr; 230(4):853-62. PubMed ID: 25204544
[TBL] [Abstract][Full Text] [Related]
18. Cyclin-dependent kinase inhibitor, P276-00, inhibits HIF-1α and induces G2/M arrest under hypoxia in prostate cancer cells.
Manohar SM; Padgaonkar AA; Jalota-Badhwar A; Rao SV; Joshi KS
Prostate Cancer Prostatic Dis; 2012 Mar; 15(1):15-27. PubMed ID: 22083267
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis, and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities.
Hong S; Kim J; Seo JH; Jung KH; Hong SS; Hong S
J Med Chem; 2012 Jun; 55(11):5337-49. PubMed ID: 22575050
[TBL] [Abstract][Full Text] [Related]
20. Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy.
Kim JH; Kim JH; Yu YS; Shin JY; Lee HY; Kim KW
J Cell Mol Med; 2008 Dec; 12(6A):2407-15. PubMed ID: 18208562
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]