BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

303 related articles for article (PubMed ID: 26462155)

  • 1. The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2α by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation.
    Zhao W; Jiang G; Bi C; Li Y; Liu J; Ye C; He H; Li L; Song D; Shao R
    Oncotarget; 2015 Nov; 6(35):37871-94. PubMed ID: 26462155
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cyclizing-berberine A35 induces G2/M arrest and apoptosis by activating YAP phosphorylation (Ser127).
    Zhao W; Liu H; Wang J; Wang M; Shao R
    J Exp Clin Cancer Res; 2018 May; 37(1):98. PubMed ID: 29728107
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Echinoside A, a new marine-derived anticancer saponin, targets topoisomerase2alpha by unique interference with its DNA binding and catalytic cycle.
    Li M; Miao ZH; Chen Z; Chen Q; Gui M; Lin LP; Sun P; Yi YH; Ding J
    Ann Oncol; 2010 Mar; 21(3):597-607. PubMed ID: 19773249
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II.
    Auzanneau C; Montaudon D; Jacquet R; Puyo S; Pouységu L; Deffieux D; Elkaoukabi-Chaibi A; De Giorgi F; Ichas F; Quideau S; Pourquier P
    Mol Pharmacol; 2012 Jul; 82(1):134-41. PubMed ID: 22528119
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde.
    Perng DS; Tsai YH; Cherng J; Wang JS; Chou KS; Shih CW; Cherng JM
    Drug Des Devel Ther; 2016; 10():141-53. PubMed ID: 26792981
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target.
    Alchanati I; Teicher C; Cohen G; Shemesh V; Barr HM; Nakache P; Ben-Avraham D; Idelevich A; Angel I; Livnah N; Tuvia S; Reiss Y; Taglicht D; Erez O
    PLoS One; 2009 Dec; 4(12):e8104. PubMed ID: 19956605
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells.
    Rao VA; Klein SR; Agama KK; Toyoda E; Adachi N; Pommier Y; Shacter EB
    Cancer Res; 2009 Feb; 69(3):948-57. PubMed ID: 19176392
    [TBL] [Abstract][Full Text] [Related]  

  • 8. NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.
    Toyoda E; Kagaya S; Cowell IG; Kurosawa A; Kamoshita K; Nishikawa K; Iiizumi S; Koyama H; Austin CA; Adachi N
    J Biol Chem; 2008 Aug; 283(35):23711-20. PubMed ID: 18596031
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells.
    Gong Y; Firestone GL; Bjeldanes LF
    Mol Pharmacol; 2006 Apr; 69(4):1320-7. PubMed ID: 16385077
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors.
    Park S; Hong E; Kwak SY; Jun KY; Lee ES; Kwon Y; Na Y
    Eur J Med Chem; 2016 Nov; 123():211-225. PubMed ID: 27484510
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II.
    Xu H; Chen Q; Wang H; Xu P; Yuan R; Li X; Bai L; Xue M
    J Exp Clin Cancer Res; 2016 Nov; 35(1):178. PubMed ID: 27852319
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Eukaryotic DNA topoisomerases mediated DNA cleavage induced by a new inhibitor: NSC 665517.
    Gupta M; Abdel-Megeed M; Hoki Y; Kohlhagen G; Paull K; Pommier Y
    Mol Pharmacol; 1995 Oct; 48(4):658-65. PubMed ID: 7476891
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.
    Lin RK; Zhou N; Lyu YL; Tsai YC; Lu CH; Kerrigan J; Chen YT; Guan Z; Hsieh TS; Liu LF
    J Biol Chem; 2011 Sep; 286(38):33591-600. PubMed ID: 21828038
    [TBL] [Abstract][Full Text] [Related]  

  • 14. NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II{alpha} and DNA-dependent protein kinase.
    Hisatomi T; Sueoka-Aragane N; Sato A; Tomimasu R; Ide M; Kurimasa A; Okamoto K; Kimura S; Sueoka E
    Blood; 2011 Mar; 117(13):3575-84. PubMed ID: 21245486
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine.
    Kim SA; Kwon Y; Kim JH; Muller MT; Chung IK
    Biochemistry; 1998 Nov; 37(46):16316-24. PubMed ID: 9819224
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.
    Yu CC; Pan SL; Chao SW; Liu SP; Hsu JL; Yang YC; Li TK; Huang WJ; Guh JH
    Biochem Pharmacol; 2014 Aug; 90(3):320-30. PubMed ID: 24915421
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Topoisomerase Inhibitors and Targeted Delivery in Cancer Therapy.
    You F; Gao C
    Curr Top Med Chem; 2019; 19(9):713-729. PubMed ID: 30931860
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.
    Robinson MJ; Osheroff N
    Biochemistry; 1991 Feb; 30(7):1807-13. PubMed ID: 1847075
    [TBL] [Abstract][Full Text] [Related]  

  • 19. N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison.
    Bender RP; Lindsey RH; Burden DA; Osheroff N
    Biochemistry; 2004 Mar; 43(12):3731-9. PubMed ID: 15035644
    [TBL] [Abstract][Full Text] [Related]  

  • 20. NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors.
    Onda T; Toyoda E; Miyazaki O; Seno C; Kagaya S; Okamoto K; Nishikawa K
    Cancer Lett; 2008 Jan; 259(1):99-110. PubMed ID: 17998154
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.