BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 26463709)

  • 1. First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3-Positive Solid Tumors.
    Meulendijks D; Jacob W; Martinez-Garcia M; Taus A; Lolkema MP; Voest EE; Langenberg MH; Fleitas Kanonnikoff T; Cervantes A; De Jonge MJ; Sleijfer S; Soerensen MM; Thomas M; Ceppi M; Meneses-Lorente G; James I; Adessi C; Michielin F; Abiraj K; Bossenmaier B; Schellens JH; Weisser M; Lassen UN
    Clin Cancer Res; 2016 Feb; 22(4):877-85. PubMed ID: 26463709
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Accelerating drug development by efficiently using emerging PK/PD data from an adaptable entry-into-human trial: example of lumretuzumab.
    Meneses-Lorente G; McIntyre C; Hsu JC; Thomas M; Jacob W; Adessi C; Weisser M
    Cancer Chemother Pharmacol; 2017 Jun; 79(6):1239-1247. PubMed ID: 28497320
    [TBL] [Abstract][Full Text] [Related]  

  • 3.
    Bensch F; Lamberts LE; Smeenk MM; Jorritsma-Smit A; Lub-de Hooge MN; Terwisscha van Scheltinga AGT; de Jong JR; Gietema JA; Schröder CP; Thomas M; Jacob W; Abiraj K; Adessi C; Meneses-Lorente G; James I; Weisser M; Brouwers AH; de Vries EGE
    Clin Cancer Res; 2017 Oct; 23(20):6128-6137. PubMed ID: 28733442
    [No Abstract]   [Full Text] [Related]  

  • 4. Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity.
    Meulendijks D; Jacob W; Voest EE; Mau-Sorensen M; Martinez-Garcia M; Taus A; Fleitas T; Cervantes A; Lolkema MP; Langenberg MHG; De Jonge MJ; Sleijfer S; Han JY; Calles A; Felip E; Kim SW; Schellens JHM; Wilson S; Thomas M; Ceppi M; Meneses-Lorente G; James I; Vega-Harring S; Dua R; Nguyen M; Steiner L; Adessi C; Michielin F; Bossenmaier B; Weisser M; Lassen UN
    Clin Cancer Res; 2017 Sep; 23(18):5406-5415. PubMed ID: 28600476
    [No Abstract]   [Full Text] [Related]  

  • 5. Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer.
    Schneeweiss A; Park-Simon TW; Albanell J; Lassen U; Cortés J; Dieras V; May M; Schindler C; Marmé F; Cejalvo JM; Martinez-Garcia M; Gonzalez I; Lopez-Martin J; Welt A; Levy C; Joly F; Michielin F; Jacob W; Adessi C; Moisan A; Meneses-Lorente G; Racek T; James I; Ceppi M; Hasmann M; Weisser M; Cervantes A
    Invest New Drugs; 2018 Oct; 36(5):848-859. PubMed ID: 29349598
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phase I pharmacokinetic and pharmacodynamic dose-escalation study of RG7160 (GA201), the first glycoengineered monoclonal antibody against the epidermal growth factor receptor, in patients with advanced solid tumors.
    Paz-Ares LG; Gomez-Roca C; Delord JP; Cervantes A; Markman B; Corral J; Soria JC; Bergé Y; Roda D; Russell-Yarde F; Hollingsworth S; Baselga J; Umana P; Manenti L; Tabernero J
    J Clin Oncol; 2011 Oct; 29(28):3783-90. PubMed ID: 21900113
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in Locally Advanced or Metastatic Epithelial Tumors.
    Juric D; Dienstmann R; Cervantes A; Hidalgo M; Messersmith W; Blumenschein GR; Tabernero J; Roda D; Calles A; Jimeno A; Wang X; Bohórquez SS; Leddy C; Littman C; Kapp AV; Shames DS; Penuel E; Amler LC; Pirzkall A; Baselga J
    Clin Cancer Res; 2015 Jun; 21(11):2462-70. PubMed ID: 26034219
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Preclinical pharmacokinetics, pharmacodynamics, and efficacy of RG7116: a novel humanized, glycoengineered anti-HER3 antibody.
    Meneses-Lorente G; Friess T; Kolm I; Hölzlwimmer G; Bader S; Meille C; Thomas M; Bossenmaier B
    Cancer Chemother Pharmacol; 2015 Apr; 75(4):837-50. PubMed ID: 25702049
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Phase 1 dose escalation study of seribantumab (MM-121), an anti-HER3 monoclonal antibody, in patients with advanced solid tumors.
    Denlinger CS; Keedy VL; Moyo V; MacBeath G; Shapiro GI
    Invest New Drugs; 2021 Dec; 39(6):1604-1612. PubMed ID: 34250553
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors.
    Papadopoulos KP; Kelley RK; Tolcher AW; Razak AR; Van Loon K; Patnaik A; Bedard PL; Alfaro AA; Beeram M; Adriaens L; Brownstein CM; Lowy I; Kostic A; Trail PA; Gao B; DiCioccio AT; Siu LL
    Clin Cancer Res; 2016 Mar; 22(6):1348-55. PubMed ID: 26490310
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A Phase I, First-in-Human Study of GSK2849330, an Anti-HER3 Monoclonal Antibody, in HER3-Expressing Solid Tumors.
    Gan HK; Millward M; Jalving M; Garrido-Laguna I; Lickliter JD; Schellens JHM; Lolkema MP; Van Herpen CLM; Hug B; Tang L; O'Connor-Semmes R; Gagnon R; Ellis C; Ganji G; Matheny C; Drilon A
    Oncologist; 2021 Oct; 26(10):e1844-e1853. PubMed ID: 34132450
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer.
    Reynolds KL; Bedard PL; Lee SH; Lin CC; Tabernero J; Alsina M; Cohen E; Baselga J; Blumenschein G; Graham DM; Garrido-Laguna I; Juric D; Sharma S; Salgia R; Seroutou A; Tian X; Fernandez R; Morozov A; Sheng Q; Ramkumar T; Zubel A; Bang YJ
    BMC Cancer; 2017 Sep; 17(1):646. PubMed ID: 28899363
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phase I study of U3-1287, a fully human anti-HER3 monoclonal antibody, in patients with advanced solid tumors.
    LoRusso P; Jänne PA; Oliveira M; Rizvi N; Malburg L; Keedy V; Yee L; Copigneaux C; Hettmann T; Wu CY; Ang A; Halim AB; Beckman RA; Beaupre D; Berlin J
    Clin Cancer Res; 2013 Jun; 19(11):3078-87. PubMed ID: 23591447
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Safety, Pharmacokinetics, and Pharmacodynamics of a Humanized Anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Solid Tumors.
    Patnaik A; Weiss GJ; Leonard JE; Rasco DW; Sachdev JC; Fisher TL; Winter LA; Reilly C; Parker RB; Mutz D; Blaydorn L; Tolcher AW; Zauderer M; Ramanathan RK
    Clin Cancer Res; 2016 Feb; 22(4):827-36. PubMed ID: 26446947
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phase I Study of Pembrolizumab (MK-3475; Anti-PD-1 Monoclonal Antibody) in Patients with Advanced Solid Tumors.
    Patnaik A; Kang SP; Rasco D; Papadopoulos KP; Elassaiss-Schaap J; Beeram M; Drengler R; Chen C; Smith L; Espino G; Gergich K; Delgado L; Daud A; Lindia JA; Li XN; Pierce RH; Yearley JH; Wu D; Laterza O; Lehnert M; Iannone R; Tolcher AW
    Clin Cancer Res; 2015 Oct; 21(19):4286-93. PubMed ID: 25977344
    [TBL] [Abstract][Full Text] [Related]  

  • 16. First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors.
    Menke-van der Houven van Oordt CW; Gomez-Roca C; van Herpen C; Coveler AL; Mahalingam D; Verheul HM; van der Graaf WT; Christen R; Rüttinger D; Weigand S; Cannarile MA; Heil F; Brewster M; Walz AC; Nayak TK; Guarin E; Meresse V; Le Tourneau C
    Oncotarget; 2016 Nov; 7(48):80046-80058. PubMed ID: 27507056
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phase I study of the HER3-targeted antibody patritumab (U3-1287) combined with erlotinib in Japanese patients with non-small cell lung cancer.
    Nishio M; Horiike A; Murakami H; Yamamoto N; Kaneda H; Nakagawa K; Horinouchi H; Nagashima M; Sekiguchi M; Tamura T
    Lung Cancer; 2015 Jun; 88(3):275-81. PubMed ID: 25891541
    [TBL] [Abstract][Full Text] [Related]  

  • 18. First-in-man phase I study of GC33, a novel recombinant humanized antibody against glypican-3, in patients with advanced hepatocellular carcinoma.
    Zhu AX; Gold PJ; El-Khoueiry AB; Abrams TA; Morikawa H; Ohishi N; Ohtomo T; Philip PA
    Clin Cancer Res; 2013 Feb; 19(4):920-8. PubMed ID: 23362325
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A continuous-time multistate Markov model to describe the occurrence and severity of diarrhea events in metastatic breast cancer patients treated with lumretuzumab in combination with pertuzumab and paclitaxel.
    Xu C; Ravva P; Dang JS; Laurent J; Adessi C; McIntyre C; Meneses-Lorente G; Mercier F
    Cancer Chemother Pharmacol; 2018 Sep; 82(3):395-406. PubMed ID: 29915982
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers.
    Lassen UN; Meulendijks D; Siu LL; Karanikas V; Mau-Sorensen M; Schellens JH; Jonker DJ; Hansen AR; Simcox ME; Schostack KJ; Bottino D; Zhong H; Roessler M; Vega-Harring SM; Jarutat T; Geho D; Wang K; DeMario M; Goss GD
    Clin Cancer Res; 2015 Jan; 21(2):258-66. PubMed ID: 25388164
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.