183 related articles for article (PubMed ID: 26494862)
1. Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination.
Huehls AM; Huntoon CJ; Joshi PM; Baehr CA; Wagner JM; Wang X; Lee MY; Karnitz LM
Mol Pharmacol; 2016 Jan; 89(1):53-62. PubMed ID: 26494862
[TBL] [Abstract][Full Text] [Related]
2. UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Pettersen HS; Visnes T; Vågbø CB; Svaasand EK; Doseth B; Slupphaug G; Kavli B; Krokan HE
Nucleic Acids Res; 2011 Oct; 39(19):8430-44. PubMed ID: 21745813
[TBL] [Abstract][Full Text] [Related]
3. 5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity.
An Q; Robins P; Lindahl T; Barnes DE
Cancer Res; 2007 Feb; 67(3):940-5. PubMed ID: 17283124
[TBL] [Abstract][Full Text] [Related]
4. SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress.
Nagaria P; Svilar D; Brown AR; Wang XH; Sobol RW; Wyatt MD
Mutat Res; 2013; 743-744():26-32. PubMed ID: 23253900
[TBL] [Abstract][Full Text] [Related]
5. Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.
Luo Y; Walla M; Wyatt MD
DNA Repair (Amst); 2008 Feb; 7(2):162-9. PubMed ID: 17942376
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil.
Christenson ES; Gizzi A; Cui J; Egleston M; Seamon KJ; DePasquale M; Orris B; Park BH; Stivers JT
Mol Pharmacol; 2021 Jun; 99(6):412-425. PubMed ID: 33795350
[TBL] [Abstract][Full Text] [Related]
7. Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase.
Fischer JA; Muller-Weeks S; Caradonna SJ
Cancer Res; 2006 Sep; 66(17):8829-37. PubMed ID: 16951200
[TBL] [Abstract][Full Text] [Related]
8. Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.
Geng L; Huehls AM; Wagner JM; Huntoon CJ; Karnitz LM
PLoS One; 2011; 6(12):e28862. PubMed ID: 22194930
[TBL] [Abstract][Full Text] [Related]
9. Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.
Grogan BC; Parker JB; Guminski AF; Stivers JT
Biochemistry; 2011 Feb; 50(5):618-27. PubMed ID: 21222484
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.
Yan Y; Han X; Qing Y; Condie AG; Gorityala S; Yang S; Xu Y; Zhang Y; Gerson SL
Oncotarget; 2016 Sep; 7(37):59299-59313. PubMed ID: 27517750
[TBL] [Abstract][Full Text] [Related]
11. dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells.
Yokogawa T; Yano W; Tsukioka S; Osada A; Wakasa T; Ueno H; Hoshino T; Yamamura K; Fujioka A; Fukuoka M; Ohkubo S; Matsuo K
Cancer Sci; 2021 Jan; 112(1):422-432. PubMed ID: 33140501
[TBL] [Abstract][Full Text] [Related]
12. Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.
Huehls AM; Wagner JM; Huntoon CJ; Geng L; Erlichman C; Patel AG; Kaufmann SH; Karnitz LM
Cancer Res; 2011 Jul; 71(14):4944-54. PubMed ID: 21613406
[TBL] [Abstract][Full Text] [Related]
13. Arabidopsis uracil DNA glycosylase (UNG) is required for base excision repair of uracil and increases plant sensitivity to 5-fluorouracil.
Córdoba-Cañero D; Dubois E; Ariza RR; Doutriaux MP; Roldán-Arjona T
J Biol Chem; 2010 Mar; 285(10):7475-83. PubMed ID: 20056608
[TBL] [Abstract][Full Text] [Related]
14. Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.
Baehr CA; Huntoon CJ; Hoang SM; Jerde CR; Karnitz LM
J Biol Chem; 2016 Dec; 291(52):26875-26885. PubMed ID: 27875297
[TBL] [Abstract][Full Text] [Related]
15. Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.
Andersen S; Heine T; Sneve R; König I; Krokan HE; Epe B; Nilsen H
Carcinogenesis; 2005 Mar; 26(3):547-55. PubMed ID: 15564287
[TBL] [Abstract][Full Text] [Related]
16. Nucleotide levels and incorporation of 5-fluorouracil and uracil into DNA of cells treated with 5-fluorodeoxyuridine.
Ingraham HA; Tseng BY; Goulian M
Mol Pharmacol; 1982 Jan; 21(1):211-6. PubMed ID: 6215571
[TBL] [Abstract][Full Text] [Related]
17. Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil.
Kunz C; Focke F; Saito Y; Schuermann D; Lettieri T; Selfridge J; Schär P
PLoS Biol; 2009 Apr; 7(4):e91. PubMed ID: 19402749
[TBL] [Abstract][Full Text] [Related]
18. Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Kemmerich K; Dingler FA; Rada C; Neuberger MS
Nucleic Acids Res; 2012 Jul; 40(13):6016-25. PubMed ID: 22447450
[TBL] [Abstract][Full Text] [Related]
19. [Development of fluoropyrimidine derivatives].
Fujii S; Shirasaka T
Gan To Kagaku Ryoho; 1984 Nov; 11(11):2316-28. PubMed ID: 6238573
[TBL] [Abstract][Full Text] [Related]
20. 5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems.
Fischer F; Baerenfaller K; Jiricny J
Gastroenterology; 2007 Dec; 133(6):1858-68. PubMed ID: 18054558
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
