BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

201 related articles for article (PubMed ID: 26506415)

  • 1. mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer.
    Cash H; Shah S; Moore E; Caruso A; Uppaluri R; Van Waes C; Allen C
    Oncotarget; 2015 Nov; 6(34):36400-17. PubMed ID: 26506415
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers.
    Moore EC; Cash HA; Caruso AM; Uppaluri R; Hodge JW; Van Waes C; Allen CT
    Cancer Immunol Res; 2016 Jul; 4(7):611-20. PubMed ID: 27076449
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells.
    Martinelli E; Troiani T; D'Aiuto E; Morgillo F; Vitagliano D; Capasso A; Costantino S; Ciuffreda LP; Merolla F; Vecchione L; De Vriendt V; Tejpar S; Nappi A; Sforza V; Martini G; Berrino L; De Palma R; Ciardiello F
    Int J Cancer; 2013 Nov; 133(9):2089-101. PubMed ID: 23629727
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade.
    Penna I; Molla A; Grazia G; Cleris L; Nicolini G; Perrone F; Picciani B; Del Vecchio M; de Braud F; Mortarini R; Anichini A
    Oncotarget; 2016 Jan; 7(4):3947-65. PubMed ID: 26678033
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment.
    Wang P; Song X; Utpatel K; Shang R; Yang YM; Xu M; Zhang J; Che L; Gordan J; Cigliano A; Seki E; Evert M; Calvisi DF; Hu X; Chen X
    Cell Death Dis; 2019 Feb; 10(2):120. PubMed ID: 30741922
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma.
    Guenther MK; Graab U; Fulda S
    Cancer Lett; 2013 Sep; 337(2):200-9. PubMed ID: 23684925
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells.
    Varin J; Poulain L; Hivelin M; Nusbaum P; Hubas A; Laurendeau I; Lantieri L; Wolkenstein P; Vidaud M; Pasmant E; Chapuis N; Parfait B
    Oncotarget; 2016 Jun; 7(24):35753-35767. PubMed ID: 26840085
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways.
    Rastogi R; Jiang Z; Ahmad N; Rosati R; Liu Y; Beuret L; Monks R; Charron J; Birnbaum MJ; Samavati L
    J Biol Chem; 2013 Nov; 288(47):33966-33977. PubMed ID: 24126911
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors.
    Sheppard KE; Cullinane C; Hannan KM; Wall M; Chan J; Barber F; Foo J; Cameron D; Neilsen A; Ng P; Ellul J; Kleinschmidt M; Kinross KM; Bowtell DD; Christensen JG; Hicks RJ; Johnstone RW; McArthur GA; Hannan RD; Phillips WA; Pearson RB
    Eur J Cancer; 2013 Dec; 49(18):3936-44. PubMed ID: 24011934
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Protection by mTOR Inhibition on Zymosan-Induced Systemic Inflammatory Response and Oxidative/Nitrosative Stress: Contribution of mTOR/MEK1/ERK1/2/IKKβ/IκB-α/NF-κB Signalling Pathway.
    Sahan-Firat S; Temiz-Resitoglu M; Guden DS; Kucukkavruk SP; Tunctan B; Sari AN; Kocak Z; Malik KU
    Inflammation; 2018 Feb; 41(1):276-298. PubMed ID: 29110153
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.
    Dungan CM; Williamson DL
    Biochem Biophys Res Commun; 2017 Jan; 482(4):1067-1072. PubMed ID: 27913296
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin.
    Du W; Gerald D; Perruzzi CA; Rodriguez-Waitkus P; Enayati L; Krishnan B; Edmonds J; Hochman ML; Lev DC; Phung TL
    Lab Invest; 2013 Oct; 93(10):1115-27. PubMed ID: 23938603
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells.
    Burmi RS; Maginn EN; Gabra H; Stronach EA; Wasan HS
    Cancer Biol Ther; 2019; 20(1):21-30. PubMed ID: 30261145
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pools of programmed death-ligand within the oral cavity tumor microenvironment: Variable alteration by targeted therapies.
    Shah S; Caruso A; Cash H; Waes CV; Allen CT
    Head Neck; 2016 Aug; 38(8):1176-86. PubMed ID: 27061215
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation.
    Paternot S; Roger PP
    Cancer Res; 2009 Jun; 69(11):4577-81. PubMed ID: 19458076
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation.
    Zhao Y; Zhao MM; Cai Y; Zheng MF; Sun WL; Zhang SY; Kong W; Gu J; Wang X; Xu MJ
    Kidney Int; 2015 Oct; 88(4):711-21. PubMed ID: 26061549
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel HSP90 inhibitor NVP-AUY922 enhances the anti-tumor effect of temsirolimus against oral squamous cell carcinoma.
    Okui T; Shimo T; Fukazawa T; Mohammad Monsur Hassan N; Honami T; Ibaragi S; Takaoka M; Naomoto Y; Sasaki A
    Curr Cancer Drug Targets; 2013 Mar; 13(3):289-99. PubMed ID: 23016912
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.
    de Stephanis L; Bonon A; Varani K; Lanza G; Gafà R; Pinton P; Pema M; Somlo S; Boletta A; Aguiari G
    Clin Exp Nephrol; 2017 Apr; 21(2):203-211. PubMed ID: 27278932
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors.
    Hassan B; Akcakanat A; Sangai T; Evans KW; Adkins F; Eterovic AK; Zhao H; Chen K; Chen H; Do KA; Xie SM; Holder AM; Naing A; Mills GB; Meric-Bernstam F
    Oncotarget; 2014 Sep; 5(18):8544-57. PubMed ID: 25261369
    [TBL] [Abstract][Full Text] [Related]  

  • 20.
    Teh JLF; Cheng PF; Purwin TJ; Nikbakht N; Patel P; Chervoneva I; Ertel A; Fortina PM; Kleiber I; HooKim K; Davies MA; Kwong LN; Levesque MP; Dummer R; Aplin AE
    Cancer Discov; 2018 May; 8(5):568-581. PubMed ID: 29496664
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.