These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 2651439)

  • 1. Discrimination between nucleotide effector responses of aspartate transcarbamoylase due to a single site substitution in the allosteric binding site.
    Corder TS; Wild JR
    J Biol Chem; 1989 May; 264(13):7425-30. PubMed ID: 2651439
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cooperative binding of the bisubstrate analog N-(phosphonacetyl)-L-aspartate to aspartate transcarbamoylase and the heterotropic effects of ATP and CTP.
    Newell JO; Markby DW; Schachman HK
    J Biol Chem; 1989 Feb; 264(5):2476-81. PubMed ID: 2644262
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Threonine 82 in the regulatory chain is important for nucleotide affinity and for the allosteric stabilization of Escherichia coli aspartate transcarbamoylase.
    Williams MK; Kantrowitz ER
    Biochim Biophys Acta; 1998 Dec; 1429(1):249-58. PubMed ID: 9920401
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Different amino acid substitutions at the same position in the nucleotide-binding site of aspartate transcarbamoylase have diverse effects on the allosteric properties of the enzyme.
    Wente SR; Schachman HK
    J Biol Chem; 1991 Nov; 266(31):20833-9. PubMed ID: 1939134
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Site-specific substitutions of the Tyr-165 residue in the catalytic chain of aspartate transcarbamoylase promotes a T-state preference in the holoenzyme.
    Wales ME; Hoover TA; Wild JR
    J Biol Chem; 1988 May; 263(13):6109-14. PubMed ID: 3283120
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effectors of Escherichia coli aspartate transcarbamoylase differentially perturb aspartate binding rather than the T-R transition.
    Hsuanyu YC; Wedler FC
    J Biol Chem; 1988 Mar; 263(9):4172-81. PubMed ID: 3279030
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Divergent allosteric patterns verify the regulatory paradigm for aspartate transcarbamylase.
    Wales ME; Madison LL; Glaser SS; Wild JR
    J Mol Biol; 1999 Dec; 294(5):1387-400. PubMed ID: 10600393
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Homotropic effects in aspartate transcarbamoylase. What happens when the enzyme binds a single molecule of the bisubstrate analog N-phosphonacetyl-L-aspartate?
    Foote J; Schachman HK
    J Mol Biol; 1985 Nov; 186(1):175-84. PubMed ID: 3908690
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Replacement of Asp-162 by Ala prevents the cooperative transition by the substrates while enhancing the effect of the allosteric activator ATP on E. coli aspartate transcarbamoylase.
    Fetler L; Tauc P; Baker DP; Macol CP; Kantrowitz ER; Vachette P
    Protein Sci; 2002 May; 11(5):1074-81. PubMed ID: 11967364
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Three of the six possible intersubunit stabilizing interactions involving Glu-239 are sufficient for restoration of the homotropic and heterotropic properties of Escherichia coli aspartate transcarbamoylase.
    Sakash JB; Chan RS; Tsuruta H; Kantrowitz ER
    J Biol Chem; 2000 Jan; 275(2):752-8. PubMed ID: 10625604
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Heterotropic effectors promote a global conformational change in aspartate transcarbamoylase.
    Eisenstein E; Markby DW; Schachman HK
    Biochemistry; 1990 Apr; 29(15):3724-31. PubMed ID: 2187530
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Importance of a conserved residue, aspartate-162, for the function of Escherichia coli aspartate transcarbamoylase.
    Newton CJ; Stevens RC; Kantrowitz ER
    Biochemistry; 1992 Mar; 31(11):3026-32. PubMed ID: 1550826
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The N-terminus of the regulatory chain of Escherichia coli aspartate transcarbamoylase is important for both nucleotide binding and heterotropic effects.
    Sakash JB; Kantrowitz ER
    Biochemistry; 1998 Jan; 37(1):281-8. PubMed ID: 9425049
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Importance of domain closure for homotropic cooperativity in Escherichia coli aspartate transcarbamylase.
    Newton CJ; Kantrowitz ER
    Biochemistry; 1990 Feb; 29(6):1444-51. PubMed ID: 2185840
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Lysine-60 in the regulatory chain of Escherichia coli aspartate transcarbamoylase is important for the discrimination between CTP and ATP.
    Zhang Y; Kantrowitz ER
    Biochemistry; 1989 Sep; 28(18):7313-8. PubMed ID: 2510822
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The allosteric activator ATP induces a substrate-dependent alteration of the quaternary structure of a mutant aspartate transcarbamoylase impaired in active site closure.
    Baker DP; Fetler L; Vachette P; Kantrowitz ER
    Protein Sci; 1996 Nov; 5(11):2276-86. PubMed ID: 8931146
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Site-directed alterations to the geometry of the aspartate transcarbamoylase zinc domain: selective alteration to regulation by heterotropic ligands, isoelectric point, and stability in urea.
    Strang CJ; Wales ME; Brown DM; Wild JR
    Biochemistry; 1993 Apr; 32(16):4156-67. PubMed ID: 8476846
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Weakening of the interface between adjacent catalytic chains promotes domain closure in Escherichia coli aspartate transcarbamoylase.
    Baker DP; Fetler L; Keiser RT; Vachette P; Kantrowitz ER
    Protein Sci; 1995 Feb; 4(2):258-67. PubMed ID: 7757014
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Importance of residues Arg-167 and Gln-231 in both the allosteric and catalytic mechanisms of Escherichia coli aspartate transcarbamoylase.
    Stebbins JW; Zhang Y; Kantrowitz ER
    Biochemistry; 1990 Apr; 29(16):3821-7. PubMed ID: 2191720
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Properties of hybrid aspartate transcarbamoylase formed with native subunits from divergent bacteria.
    Shanley MS; Foltermann KF; O'Donovan GA; Wild JR
    J Biol Chem; 1984 Oct; 259(20):12672-7. PubMed ID: 6386799
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.