BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

229 related articles for article (PubMed ID: 26515069)

  • 1. Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate.
    Knihtila R; Holzapfel G; Weiss K; Meilleur F; Mattos C
    J Biol Chem; 2015 Dec; 290(52):31025-36. PubMed ID: 26515069
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ras-catalyzed hydrolysis of GTP: a new perspective from model studies.
    Maegley KA; Admiraal SJ; Herschlag D
    Proc Natl Acad Sci U S A; 1996 Aug; 93(16):8160-6. PubMed ID: 8710841
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
    Xu S; Long BN; Boris GH; Chen A; Ni S; Kennedy MA
    Acta Crystallogr D Struct Biol; 2017 Dec; 73(Pt 12):970-984. PubMed ID: 29199977
    [TBL] [Abstract][Full Text] [Related]  

  • 4. X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.
    Privé GG; Milburn MV; Tong L; de Vos AM; Yamaizumi Z; Nishimura S; Kim SH
    Proc Natl Acad Sci U S A; 1992 Apr; 89(8):3649-53. PubMed ID: 1565661
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.
    Spoerner M; Hozsa C; Poetzl JA; Reiss K; Ganser P; Geyer M; Kalbitzer HR
    J Biol Chem; 2010 Dec; 285(51):39768-78. PubMed ID: 20937837
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.
    Schweins T; Geyer M; Kalbitzer HR; Wittinghofer A; Warshel A
    Biochemistry; 1996 Nov; 35(45):14225-31. PubMed ID: 8916907
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The protonation states of GTP and GppNHp in Ras proteins.
    Mann D; Güldenhaupt J; Schartner J; Gerwert K; Kötting C
    J Biol Chem; 2018 Mar; 293(11):3871-3879. PubMed ID: 29382720
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanisms of guanosine triphosphate hydrolysis by Ras and Ras-GAP proteins as rationalized by ab initio QM/MM simulations.
    Grigorenko BL; Nemukhin AV; Shadrina MS; Topol IA; Burt SK
    Proteins; 2007 Feb; 66(2):456-66. PubMed ID: 17094109
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate.
    Cepus V; Scheidig AJ; Goody RS; Gerwert K
    Biochemistry; 1998 Jul; 37(28):10263-71. PubMed ID: 9665734
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.
    Scheidig AJ; Burmester C; Goody RS
    Structure; 1999 Nov; 7(11):1311-24. PubMed ID: 10574788
    [TBL] [Abstract][Full Text] [Related]  

  • 11. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
    Lu S; Banerjee A; Jang H; Zhang J; Gaponenko V; Nussinov R
    J Biol Chem; 2015 Nov; 290(48):28887-900. PubMed ID: 26453300
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dissection of the GTPase mechanism of Ras protein by MD analysis of Ras mutants.
    Friedman ZY; Devary Y
    Proteins; 2005 May; 59(3):528-33. PubMed ID: 15789417
    [TBL] [Abstract][Full Text] [Related]  

  • 13. gamma-phosphate protonation and pH-dependent unfolding of the Ras.GTP.Mg2+ complex: a vibrational spectroscopy study.
    Cheng H; Sukal S; Callender R; Leyh TS
    J Biol Chem; 2001 Mar; 276(13):9931-5. PubMed ID: 11124953
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ras catalyzes GTP hydrolysis by shifting negative charges from gamma- to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy.
    Allin C; Gerwert K
    Biochemistry; 2001 Mar; 40(10):3037-46. PubMed ID: 11258917
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Prediction of the GTPase activities by using the semiempirical molecular orbital theory.
    Kinoshita H; Shimizu K
    Bioorg Med Chem Lett; 1998 May; 8(9):1083-8. PubMed ID: 9871712
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study.
    Frech M; Darden TA; Pedersen LG; Foley CK; Charifson PS; Anderson MW; Wittinghofer A
    Biochemistry; 1994 Mar; 33(11):3237-44. PubMed ID: 8136358
    [TBL] [Abstract][Full Text] [Related]  

  • 17. QM/MM modeling the Ras-GAP catalyzed hydrolysis of guanosine triphosphate.
    Grigorenko BL; Nemukhin AV; Topol IA; Cachau RE; Burt SK
    Proteins; 2005 Aug; 60(3):495-503. PubMed ID: 15906320
    [TBL] [Abstract][Full Text] [Related]  

  • 18. What is the role of the helical domain of Gsalpha in the GTPase reaction?
    Shnerb T; Lin N; Shurki A
    Biochemistry; 2007 Sep; 46(38):10875-85. PubMed ID: 17727271
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.
    Johnson CW; Reid D; Parker JA; Salter S; Knihtila R; Kuzmic P; Mattos C
    J Biol Chem; 2017 Aug; 292(31):12981-12993. PubMed ID: 28630043
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers.
    Araki M; Shima F; Yoshikawa Y; Muraoka S; Ijiri Y; Nagahara Y; Shirono T; Kataoka T; Tamura A
    J Biol Chem; 2011 Nov; 286(45):39644-53. PubMed ID: 21930707
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.