BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

224 related articles for article (PubMed ID: 26530776)

  • 1. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease.
    Wang X; Perumalsamy H; Kwon HW; Na YE; Ahn YJ
    Sci Rep; 2015 Nov; 5():16127. PubMed ID: 26530776
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models.
    Wang X; Kim JR; Lee SB; Kim YJ; Jung MY; Kwon HW; Ahn YJ
    BMC Complement Altern Med; 2014 Mar; 14():88. PubMed ID: 24597901
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.
    Johnson ECB; Ho K; Yu GQ; Das M; Sanchez PE; Djukic B; Lopez I; Yu X; Gill M; Zhang W; Paz JT; Palop JJ; Mucke L
    Mol Neurodegener; 2020 Sep; 15(1):53. PubMed ID: 32921309
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Icariin decreases the expression of APP and BACE-1 and reduces the β-amyloid burden in an APP transgenic mouse model of Alzheimer's disease.
    Zhang L; Shen C; Chu J; Zhang R; Li Y; Li L
    Int J Biol Sci; 2014; 10(2):181-91. PubMed ID: 24550686
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MicroRNA-384 regulates both amyloid precursor protein and β-secretase expression and is a potential biomarker for Alzheimer's disease.
    Liu CG; Wang JL; Li L; Wang PC
    Int J Mol Med; 2014 Jul; 34(1):160-6. PubMed ID: 24827165
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.
    Paris D; Ganey NJ; Laporte V; Patel NS; Beaulieu-Abdelahad D; Bachmeier C; March A; Ait-Ghezala G; Mullan MJ
    J Neuroinflammation; 2010 Mar; 7():17. PubMed ID: 20211007
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.
    Paumier JM; Py NA; García-González L; Bernard A; Stephan D; Louis L; Checler F; Khrestchatisky M; Baranger K; Rivera S
    FASEB J; 2019 Feb; 33(2):2910-2927. PubMed ID: 30332299
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
    Sadleir KR; Eimer WA; Kaufman RJ; Osten P; Vassar R
    PLoS One; 2014; 9(7):e101643. PubMed ID: 24992504
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage.
    Netzer WJ; Bettayeb K; Sinha SC; Flajolet M; Greengard P; Bustos V
    Proc Natl Acad Sci U S A; 2017 Feb; 114(6):1389-1394. PubMed ID: 28115709
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
    Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
    Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synaptic abnormalities in a Drosophila model of Alzheimer's disease.
    Mhatre SD; Satyasi V; Killen M; Paddock BE; Moir RD; Saunders AJ; Marenda DR
    Dis Model Mech; 2014 Mar; 7(3):373-85. PubMed ID: 24487408
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo.
    Kim ML; Zhang B; Mills IP; Milla ME; Brunden KR; Lee VM
    J Neurosci; 2008 Nov; 28(46):12052-61. PubMed ID: 19005070
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis.
    Sun J; Roy S
    Dev Neurobiol; 2018 Mar; 78(3):340-347. PubMed ID: 29106038
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A; Hata S; Suzuki T
    J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
    J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.
    Mao P; Manczak M; Calkins MJ; Truong Q; Reddy TP; Reddy AP; Shirendeb U; Lo HH; Rabinovitch PS; Reddy PH
    Hum Mol Genet; 2012 Jul; 21(13):2973-90. PubMed ID: 22492996
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 18. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.
    Kim W; Ma L; Lomoio S; Willen R; Lombardo S; Dong J; Haydon PG; Tesco G
    Mol Neurodegener; 2018 Feb; 13(1):6. PubMed ID: 29391027
    [TBL] [Abstract][Full Text] [Related]  

  • 19. AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice.
    Eketjäll S; Janson J; Jeppsson F; Svanhagen A; Kolmodin K; Gustavsson S; Radesäter AC; Eliason K; Briem S; Appelkvist P; Niva C; Berg AL; Karlström S; Swahn BM; Fälting J
    J Neurosci; 2013 Jun; 33(24):10075-84. PubMed ID: 23761903
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.
    Zhao Y; Wang Y; Yang J; Wang X; Zhao Y; Zhang X; Zhang YW
    Mol Neurodegener; 2012 Jun; 7():30. PubMed ID: 22709416
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.