BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 26534882)

  • 1. Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry.
    Pacholarz KJ; Peters SJ; Garlish RA; Henry AJ; Taylor RJ; Humphreys DP; Barran PE
    Chembiochem; 2016 Jan; 17(1):46-51. PubMed ID: 26534882
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability.
    Edgeworth MJ; Phillips JJ; Lowe DC; Kippen AD; Higazi DR; Scrivens JH
    Angew Chem Int Ed Engl; 2015 Dec; 54(50):15156-9. PubMed ID: 26482340
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Probing Conformational Diversity of Fc Domains in Aggregation-Prone Monoclonal Antibodies.
    Majumder S; Jones MT; Kimmel M; Alphonse Ignatius A
    Pharm Res; 2018 Sep; 35(11):220. PubMed ID: 30255351
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Stability of monoclonal antibodies at high-concentration: head-to-head comparison of the IgG1 and IgG4 subclass.
    Neergaard MS; Nielsen AD; Parshad H; Van De Weert M
    J Pharm Sci; 2014 Jan; 103(1):115-27. PubMed ID: 24282022
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.
    Majumdar R; Esfandiary R; Bishop SM; Samra HS; Middaugh CR; Volkin DB; Weis DD
    MAbs; 2015; 7(1):84-95. PubMed ID: 25524268
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Native Mass Spectrometry, Ion Mobility, and Collision-Induced Unfolding for Conformational Characterization of IgG4 Monoclonal Antibodies.
    Hernandez-Alba O; Wagner-Rousset E; Beck A; Cianférani S
    Anal Chem; 2018 Aug; 90(15):8865-8872. PubMed ID: 29956914
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Middle Level IM-MS and CIU Experiments for Improved Therapeutic Immunoglobulin Subclass Fingerprinting.
    Botzanowski T; Hernandez-Alba O; Malissard M; Wagner-Rousset E; Deslignière E; Colas O; Haeuw JF; Beck A; Cianférani S
    Anal Chem; 2020 Jul; 92(13):8827-8835. PubMed ID: 32453570
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Insights from native mass spectrometry and ion mobility-mass spectrometry for antibody and antibody-based product characterization.
    Terral G; Beck A; Cianférani S
    J Chromatogr B Analyt Technol Biomed Life Sci; 2016 Oct; 1032():79-90. PubMed ID: 27108304
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Investigating the Degradation Behaviors of a Therapeutic Monoclonal Antibody Associated with pH and Buffer Species.
    Zheng S; Qiu D; Adams M; Li J; Mantri RV; Gandhi R
    AAPS PharmSciTech; 2017 Jan; 18(1):42-48. PubMed ID: 26340951
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Understanding the conformational impact of chemical modifications on monoclonal antibodies with diverse sequence variation using hydrogen/deuterium exchange mass spectrometry and structural modeling.
    Zhang A; Hu P; MacGregor P; Xue Y; Fan H; Suchecki P; Olszewski L; Liu A
    Anal Chem; 2014 Apr; 86(7):3468-75. PubMed ID: 24597564
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related products.
    Ehkirch A; Hernandez-Alba O; Colas O; Beck A; Guillarme D; Cianférani S
    J Chromatogr B Analyt Technol Biomed Life Sci; 2018 Jun; 1086():176-183. PubMed ID: 29684909
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Examination of thermal unfolding and aggregation profiles of a series of developable therapeutic monoclonal antibodies.
    Brader ML; Estey T; Bai S; Alston RW; Lucas KK; Lantz S; Landsman P; Maloney KM
    Mol Pharm; 2015 Apr; 12(4):1005-17. PubMed ID: 25687223
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions.
    Bhambhani A; Kissmann JM; Joshi SB; Volkin DB; Kashi RS; Middaugh CR
    J Pharm Sci; 2012 Mar; 101(3):1120-35. PubMed ID: 22147527
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies.
    Thakkar SV; Joshi SB; Jones ME; Sathish HA; Bishop SM; Volkin DB; Middaugh CR
    J Pharm Sci; 2012 Sep; 101(9):3062-77. PubMed ID: 22581714
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A Mass-Spectrometry-Based Modelling Workflow for Accurate Prediction of IgG Antibody Conformations in the Gas Phase.
    Hansen K; Lau AM; Giles K; McDonnell JM; Struwe WB; Sutton BJ; Politis A
    Angew Chem Int Ed Engl; 2018 Dec; 57(52):17194-17199. PubMed ID: 30408305
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry.
    Wang G; Bondarenko PV; Kaltashov IA
    Analyst; 2018 Feb; 143(3):670-677. PubMed ID: 29303166
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Benefits and Limitations of High-Resolution Cyclic IM-MS for Conformational Characterization of Native Therapeutic Monoclonal Antibodies.
    Deslignière E; Ollivier S; Beck A; Ropartz D; Rogniaux H; Cianférani S
    Anal Chem; 2023 Feb; 95(8):4162-4171. PubMed ID: 36780376
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry.
    Xu J; Coughlin JE; Szyjka M; Jabary S; Saluja S; Sosic Z; Chen Y; Xu CF
    MAbs; 2024; 16(1):2334783. PubMed ID: 38536719
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Local dynamics and their alteration by excipients modulate the global conformational stability of an lgG1 monoclonal antibody.
    Thakkar SV; Kim JH; Samra HS; Sathish HA; Bishop SM; Joshi SB; Volkin DB; Middaugh CR
    J Pharm Sci; 2012 Dec; 101(12):4444-57. PubMed ID: 23060088
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody.
    Arora J; Hickey JM; Majumdar R; Esfandiary R; Bishop SM; Samra HS; Middaugh CR; Weis DD; Volkin DB
    MAbs; 2015; 7(3):525-39. PubMed ID: 25875351
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.