299 related articles for article (PubMed ID: 26536)
1. Pharmacokinetic model of presystemic metabolism.
Colburn WA; Gibaldi M
Drug Metab Dispos; 1978; 6(2):193-6. PubMed ID: 26536
[TBL] [Abstract][Full Text] [Related]
2. Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.
Pang KS; Chow EC
Drug Metab Dispos; 2012 Oct; 40(10):1869-77. PubMed ID: 22745334
[TBL] [Abstract][Full Text] [Related]
3. Influence of administration route and blood sampling site on the area under the curve. Assessment of gut wall, liver, and lung metabolism from a physiological model.
Klippert PJ; Noordhoek J
Drug Metab Dispos; 1983; 11(1):62-6. PubMed ID: 6132799
[TBL] [Abstract][Full Text] [Related]
4. Quantification of absorption, intestinal and hepatic first pass effect in a chronic dog model.
Lemaire M; Bodoky A; Heberer M; Niederberger W
Eur J Drug Metab Pharmacokinet; 1991; Spec No 3():132-5. PubMed ID: 1820867
[TBL] [Abstract][Full Text] [Related]
5. A pharmacokinetic model to differentiate preabsorptive, gut epithelial, and hepatic first-pass metabolism.
Colburn WA
J Pharmacokinet Biopharm; 1979 Aug; 7(4):407-15. PubMed ID: 512846
[TBL] [Abstract][Full Text] [Related]
6. Presystemic and systemic intestinal metabolism of fenoterol in the conscious rat.
Koster AS; Hofman GA; Frankhuijzen-Sierevogel AC; Noordhoek J
Drug Metab Dispos; 1985; 13(4):464-70. PubMed ID: 2863112
[TBL] [Abstract][Full Text] [Related]
7. A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism.
Cong D; Doherty M; Pang KS
Drug Metab Dispos; 2000 Feb; 28(2):224-35. PubMed ID: 10640522
[TBL] [Abstract][Full Text] [Related]
8. Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
Kharasch ED; Walker A; Hoffer C; Sheffels P
Clin Pharmacol Ther; 2004 Nov; 76(5):452-66. PubMed ID: 15536460
[TBL] [Abstract][Full Text] [Related]
9. Evaluation of gastrointestinal absorption and metabolism.
Zimmerman CL; Wen Y; Soria I; Pithavala YK
Drug Metab Rev; 1997 Nov; 29(4):957-75. PubMed ID: 9421681
[No Abstract] [Full Text] [Related]
10. Analysis and prediction of absorption profile including hepatic first-pass metabolism of N-methyltyramine, a potent stimulant of gastrin release present in beer, after oral ingestion in rats by gastrointestinal-transit-absorption model.
Kimura T; Iwasaki N; Yokoe JI; Haruta S; Yokoo Y; Ogawara KI; Higaki K
Drug Metab Dispos; 2000 May; 28(5):577-81. PubMed ID: 10772638
[TBL] [Abstract][Full Text] [Related]
11. Does the well-stirred model assess the intestinal first-pass effect well?
Mizuma T; Tsuji A; Hayashi M
J Pharm Pharmacol; 2004 Dec; 56(12):1597-9. PubMed ID: 15563767
[TBL] [Abstract][Full Text] [Related]
12. [The bioavailability of orally administered drugs with special regard to the liver as a filter for foreign matter].
Raaflaub J
Schweiz Med Wochenschr; 1980 Mar; 110(10):354-62. PubMed ID: 7394464
[TBL] [Abstract][Full Text] [Related]
13. Assessment of intestinal availability of various drugs in the oral absorption process using portal vein-cannulated rats.
Matsuda Y; Konno Y; Satsukawa M; Kobayashi T; Takimoto Y; Morisaki K; Yamashita S
Drug Metab Dispos; 2012 Dec; 40(12):2231-8. PubMed ID: 22930277
[TBL] [Abstract][Full Text] [Related]
14. [First-past Effect (author's transl)].
Leopold G
Arzneimittelforschung; 1977 Feb; 27(2A):241-9. PubMed ID: 577169
[TBL] [Abstract][Full Text] [Related]
15. Estimating human drug oral absorption kinetics from Caco-2 permeability using an absorption-disposition model: model development and evaluation and derivation of analytical solutions for k(a) and F(a).
Usansky HH; Sinko PJ
J Pharmacol Exp Ther; 2005 Jul; 314(1):391-9. PubMed ID: 15833900
[TBL] [Abstract][Full Text] [Related]
16. Role of gut contents, intestinal wall, and liver on the first pass metabolism and absolute bioavailability of isotretinoin in the dog.
Cotler S; Buggé CJ; Colburn WA
Drug Metab Dispos; 1983; 11(5):458-62. PubMed ID: 6138231
[TBL] [Abstract][Full Text] [Related]
17. A new model-independent physiological approach to study hepatic drug clearance and its applications.
Chiou WL
Int J Clin Pharmacol Ther Toxicol; 1984 Nov; 22(11):577-90. PubMed ID: 6389376
[TBL] [Abstract][Full Text] [Related]
18. Estimating drug solubility in the gastrointestinal tract.
Dressman JB; Vertzoni M; Goumas K; Reppas C
Adv Drug Deliv Rev; 2007 Jul; 59(7):591-602. PubMed ID: 17599644
[TBL] [Abstract][Full Text] [Related]
19. In vivo O-de-ethylation of phenacetin in 3-methylcholanthrene-pretreated rats: gut wall and liver first-pass metabolism.
Klippert PJ; Littel RJ; Noordhoek J
J Pharmacol Exp Ther; 1983 Apr; 225(1):153-7. PubMed ID: 6834267
[TBL] [Abstract][Full Text] [Related]
20. [Side effects of drugs in the elderly. A review of various possible causes].
van Bezooijen CF
Tijdschr Gerontol Geriatr; 1985 Oct; 16(5):191-8. PubMed ID: 3909542
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
