BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

627 related articles for article (PubMed ID: 26543160)

  • 21. Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism.
    Dyachok J; Earnest S; Iturraran EN; Cobb MH; Ross EM
    J Biol Chem; 2016 Oct; 291(43):22414-22426. PubMed ID: 27587390
    [TBL] [Abstract][Full Text] [Related]  

  • 22. ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation.
    Xu D; Dai W; Kutzler L; Lacko HA; Jefferson LS; Dennis MD; Kimball SR
    J Nutr; 2020 May; 150(5):1022-1030. PubMed ID: 31875479
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK.
    Jin HR; Du CH; Wang CZ; Yuan CS; Du W
    Cell Death Dis; 2019 Apr; 10(4):311. PubMed ID: 30952841
    [TBL] [Abstract][Full Text] [Related]  

  • 24. mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
    Wyant GA; Abu-Remaileh M; Wolfson RL; Chen WW; Freinkman E; Danai LV; Vander Heiden MG; Sabatini DM
    Cell; 2017 Oct; 171(3):642-654.e12. PubMed ID: 29053970
    [TBL] [Abstract][Full Text] [Related]  

  • 25. SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1.
    Rebsamen M; Superti-Furga G
    Autophagy; 2016 Jun; 12(6):1061-2. PubMed ID: 26431368
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
    Castellano BM; Thelen AM; Moldavski O; Feltes M; van der Welle RE; Mydock-McGrane L; Jiang X; van Eijkeren RJ; Davis OB; Louie SM; Perera RM; Covey DF; Nomura DK; Ory DS; Zoncu R
    Science; 2017 Mar; 355(6331):1306-1311. PubMed ID: 28336668
    [TBL] [Abstract][Full Text] [Related]  

  • 27. A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling.
    Brüggenthies JB; Fiore A; Russier M; Bitsina C; Brötzmann J; Kordes S; Menninger S; Wolf A; Conti E; Eickhoff JE; Murray PJ
    J Biol Chem; 2022 Dec; 298(12):102629. PubMed ID: 36273589
    [TBL] [Abstract][Full Text] [Related]  

  • 28. mTORC1: turning off is just as important as turning on.
    Benjamin D; Hall MN
    Cell; 2014 Feb; 156(4):627-8. PubMed ID: 24529368
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.
    Lee M; Kim JH; Yoon I; Lee C; Fallahi Sichani M; Kang JS; Kang J; Guo M; Lee KY; Han G; Kim S; Han JM
    Proc Natl Acad Sci U S A; 2018 Jun; 115(23):E5279-E5288. PubMed ID: 29784813
    [TBL] [Abstract][Full Text] [Related]  

  • 30. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
    Wolfson RL; Chantranupong L; Wyant GA; Gu X; Orozco JM; Shen K; Condon KJ; Petri S; Kedir J; Scaria SM; Abu-Remaileh M; Frankel WN; Sabatini DM
    Nature; 2017 Mar; 543(7645):438-442. PubMed ID: 28199306
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Multiple amino acid sensing inputs to mTORC1.
    Shimobayashi M; Hall MN
    Cell Res; 2016 Jan; 26(1):7-20. PubMed ID: 26658722
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis.
    Jin HO; Hong SE; Kim JY; Jang SK; Park IC
    Cell Death Dis; 2021 Dec; 12(12):1127. PubMed ID: 34862383
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The amino acid transporter SLC38A9 regulates MTORC1 and autophagy.
    Jin M; Klionsky DJ
    Autophagy; 2015; 11(10):1709-10. PubMed ID: 26506891
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
    Wengrod J; Wang D; Weiss S; Zhong H; Osman I; Gardner LB
    Sci Signal; 2015 Mar; 8(367):ra27. PubMed ID: 25759478
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Fission yeast TORC1 prevents eIF2α phosphorylation in response to nitrogen and amino acids via Gcn2 kinase.
    Valbuena N; Rozalén AE; Moreno S
    J Cell Sci; 2012 Dec; 125(Pt 24):5955-9. PubMed ID: 23108671
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.
    Saxton RA; Knockenhauer KE; Wolfson RL; Chantranupong L; Pacold ME; Wang T; Schwartz TU; Sabatini DM
    Science; 2016 Jan; 351(6268):53-8. PubMed ID: 26586190
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1.
    Blagojevic B; Almouhanna F; Poschet G; Wölfl S
    Cells; 2022 Nov; 11(23):. PubMed ID: 36497120
    [TBL] [Abstract][Full Text] [Related]  

  • 38. GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress.
    Kato Y; Kunimasa K; Takahashi M; Harada A; Nagasawa I; Osawa M; Sugimoto Y; Tomida A
    Mol Pharmacol; 2020 Dec; 98(6):669-676. PubMed ID: 33033108
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism.
    Schriever SC; Deutsch MJ; Adamski J; Roscher AA; Ensenauer R
    J Nutr Biochem; 2013 May; 24(5):824-31. PubMed ID: 22898570
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Regulation of mTORC1 by amino acids.
    Bar-Peled L; Sabatini DM
    Trends Cell Biol; 2014 Jul; 24(7):400-6. PubMed ID: 24698685
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 32.