261 related articles for article (PubMed ID: 26549032)
1. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.
Ksionda O; Melton AA; Bache J; Tenhagen M; Bakker J; Harvey R; Winter SS; Rubio I; Roose JP
Oncogene; 2016 Jul; 35(28):3658-68. PubMed ID: 26549032
[TBL] [Abstract][Full Text] [Related]
2. Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
Hartzell C; Ksionda O; Lemmens E; Coakley K; Yang M; Dail M; Harvey RC; Govern C; Bakker J; Lenstra TL; Ammon K; Boeter A; Winter SS; Loh M; Shannon K; Chakraborty AK; Wabl M; Roose JP
Sci Signal; 2013 Mar; 6(268):ra21. PubMed ID: 23532335
[TBL] [Abstract][Full Text] [Related]
3. Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis.
Karra L; Romero-Moya D; Ksionda O; Krush M; Gu Z; Mues M; Depeille P; Mullighan C; Roose JP
Oncogene; 2020 Nov; 39(45):6920-6934. PubMed ID: 32989257
[TBL] [Abstract][Full Text] [Related]
4. Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle.
Mues M; Roose JP
Small GTPases; 2017 Jan; 8(1):20-25. PubMed ID: 27159504
[TBL] [Abstract][Full Text] [Related]
5. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
Roose JP; Mollenauer M; Gupta VA; Stone J; Weiss A
Mol Cell Biol; 2005 Jun; 25(11):4426-41. PubMed ID: 15899849
[TBL] [Abstract][Full Text] [Related]
6. Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
Wen Z; Yun G; Hebert A; Kong G; Ranheim EA; Finn R; Rajagoplan A; Li S; Zhou Y; Yu M; Damnernsawad A; Roose JP; Coon JJ; Wen R; Wang D; Zhang J
Blood; 2021 Jun; 137(23):3259-3271. PubMed ID: 33512434
[TBL] [Abstract][Full Text] [Related]
7. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.
Ksionda O; Mues M; Wandler AM; Donker L; Tenhagen M; Jun J; Ducker GS; Matlawska-Wasowska K; Shannon K; Shokat KM; Roose JP
PLoS One; 2018; 13(5):e0193849. PubMed ID: 29799846
[TBL] [Abstract][Full Text] [Related]
8. RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.
Guilbault B; Kay RJ
J Biol Chem; 2004 May; 279(19):19523-30. PubMed ID: 14970203
[TBL] [Abstract][Full Text] [Related]
9. Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.
Carrasco S; Merida I
Mol Biol Cell; 2004 Jun; 15(6):2932-42. PubMed ID: 15064353
[TBL] [Abstract][Full Text] [Related]
10. RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.
Ruiz S; Santos E; Bustelo XR
Mol Cell Biol; 2007 Dec; 27(23):8127-42. PubMed ID: 17923690
[TBL] [Abstract][Full Text] [Related]
11. Investigating increased hematopoietic stem cell fitness in a novel mouse model.
Karra L; Roose JP
Small GTPases; 2022 Jan; 13(1):7-13. PubMed ID: 33517841
[TBL] [Abstract][Full Text] [Related]
12. A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer.
Hsu TC; Rodrigues GOL; Winer H; Hixon JA; Li W; Tarasova NI; Durum SK
Int J Mol Sci; 2023 Jan; 24(2):. PubMed ID: 36675167
[TBL] [Abstract][Full Text] [Related]
13. Inverted signaling hierarchy between RAS and RAC in T-lymphocytes.
Zugaza JL; Caloca MJ; Bustelo XR
Oncogene; 2004 Jul; 23(34):5823-33. PubMed ID: 15184873
[TBL] [Abstract][Full Text] [Related]
14. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.
Felekkis KN; Narsimhan RP; Near R; Castro AF; Zheng Y; Quilliam LA; Lerner A
Mol Cancer Res; 2005 Jan; 3(1):32-41. PubMed ID: 15671247
[TBL] [Abstract][Full Text] [Related]
15. BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma.
Tian XP; Cai J; Ma SY; Fang Y; Huang HQ; Lin TY; Rao HL; Li M; Xia ZJ; Kang TB; Xie D; Cai QQ
Cancer Commun (Lond); 2020 Jun; 40(6):245-259. PubMed ID: 32459053
[TBL] [Abstract][Full Text] [Related]
16. SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.
Kosco KA; Cerignoli F; Williams S; Abraham RT; Mustelin T
Mol Immunol; 2008 Jan; 45(2):510-22. PubMed ID: 17658605
[TBL] [Abstract][Full Text] [Related]
17. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.
Bivona TG; PĂ©rez De Castro I; Ahearn IM; Grana TM; Chiu VK; Lockyer PJ; Cullen PJ; Pellicer A; Cox AD; Philips MR
Nature; 2003 Aug; 424(6949):694-8. PubMed ID: 12845332
[TBL] [Abstract][Full Text] [Related]
18. PI3K/AKT/mTORC1 and MEK/ERK signaling in T-cell acute lymphoblastic leukemia: new options for targeted therapy.
Martelli AM; Tabellini G; Ricci F; Evangelisti C; Chiarini F; Bortul R; McCubrey JA; Manzoli FA
Adv Biol Regul; 2012 Jan; 52(1):214-27. PubMed ID: 21983557
[No Abstract] [Full Text] [Related]
19. Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.
Johnson JE; Goulding RE; Ding Z; Partovi A; Anthony KV; Beaulieu N; Tazmini G; Cornell RB; Kay RJ
Biochem J; 2007 Sep; 406(2):223-36. PubMed ID: 17523924
[TBL] [Abstract][Full Text] [Related]
20. Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.
Reynolds LF; de Bettignies C; Norton T; Beeser A; Chernoff J; Tybulewicz VL
J Biol Chem; 2004 Apr; 279(18):18239-46. PubMed ID: 14764585
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]