118 related articles for article (PubMed ID: 26560855)
1. Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies.
Bach A; Pizzirani D; Realini N; Vozella V; Russo D; Penna I; Melzig L; Scarpelli R; Piomelli D
J Med Chem; 2015 Dec; 58(23):9258-72. PubMed ID: 26560855
[TBL] [Abstract][Full Text] [Related]
2. Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase.
Pizzirani D; Bach A; Realini N; Armirotti A; Mengatto L; Bauer I; Girotto S; Pagliuca C; De Vivo M; Summa M; Ribeiro A; Piomelli D
Angew Chem Int Ed Engl; 2015 Jan; 54(2):485-9. PubMed ID: 25395373
[TBL] [Abstract][Full Text] [Related]
3. Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR).
Pizzirani D; Pagliuca C; Realini N; Branduardi D; Bottegoni G; Mor M; Bertozzi F; Scarpelli R; Piomelli D; Bandiera T
J Med Chem; 2013 May; 56(9):3518-30. PubMed ID: 23614460
[TBL] [Abstract][Full Text] [Related]
4. Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors.
Di Martino S; Tardia P; Cilibrasi V; Caputo S; Mazzonna M; Russo D; Penna I; Realini N; Margaroli N; Migliore M; Pizzirani D; Ottonello G; Bertozzi SM; Armirotti A; Nguyen D; Sun Y; Bongarzone ER; Lansbury P; Liu M; Skerlj R; Scarpelli R
J Med Chem; 2020 Apr; 63(7):3634-3664. PubMed ID: 32176488
[TBL] [Abstract][Full Text] [Related]
5. Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors.
Caputo S; Di Martino S; Cilibrasi V; Tardia P; Mazzonna M; Russo D; Penna I; Summa M; Bertozzi SM; Realini N; Margaroli N; Migliore M; Ottonello G; Liu M; Lansbury P; Armirotti A; Bertorelli R; Ray SS; Skerlj R; Scarpelli R
J Med Chem; 2020 Dec; 63(24):15821-15851. PubMed ID: 33290061
[TBL] [Abstract][Full Text] [Related]
6. Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells.
Morad SA; Levin JC; Tan SF; Fox TE; Feith DJ; Cabot MC
Biochim Biophys Acta; 2013 Dec; 1831(12):1657-64. PubMed ID: 23939396
[TBL] [Abstract][Full Text] [Related]
7. Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.
Ortega JA; Arencibia JM; La Sala G; Borgogno M; Bauer I; Bono L; Braccia C; Armirotti A; Girotto S; Ganesan A; De Vivo M
J Med Chem; 2017 Jul; 60(13):5800-5815. PubMed ID: 28603987
[TBL] [Abstract][Full Text] [Related]
8. C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.
Flowers M; Fabriás G; Delgado A; Casas J; Abad JL; Cabot MC
Breast Cancer Res Treat; 2012 Jun; 133(2):447-58. PubMed ID: 21935601
[TBL] [Abstract][Full Text] [Related]
9. Synthesis of some 2(3H)-benzoxazolone derivatives and their in-vitro effects on human leukocyte myeloperoxidase activity.
Soyer Z; Bas M; Pabuccuoglu A; Pabuccuoglu V
Arch Pharm (Weinheim); 2005 Sep; 338(9):405-10. PubMed ID: 16143956
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and biological activity of 4-substituted benzoxazolone derivatives as a new class of sEH inhibitors with high anti-inflammatory activity in vivo.
Tang L; Ma WH; Ma YL; Ban SR; Feng XE; Li QS
Bioorg Med Chem Lett; 2013 Apr; 23(8):2380-3. PubMed ID: 23489630
[TBL] [Abstract][Full Text] [Related]
11. Acid ceramidase, an emerging target for anti-cancer and anti-angiogenesis.
Cho SM; Kwon HJ
Arch Pharm Res; 2019 Mar; 42(3):232-243. PubMed ID: 30661200
[TBL] [Abstract][Full Text] [Related]
12. Progress in the development of β-lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives.
Petracca R; Ponzano S; Bertozzi SM; Sasso O; Piomelli D; Bandiera T; Bertozzi F
Eur J Med Chem; 2017 Jan; 126():561-575. PubMed ID: 27915171
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.
Walker DP; Arhancet GB; Lu HF; Heasley SE; Metz S; Kablaoui NM; Franco FM; Hanau CE; Scholten JA; Springer JR; Fobian YM; Carter JS; Xing L; Yang S; Shaffer AF; Jerome GM; Baratta MT; Moore WM; Vazquez ML
Bioorg Med Chem Lett; 2013 Feb; 23(4):1120-6. PubMed ID: 23298810
[TBL] [Abstract][Full Text] [Related]
14. Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues.
Bhabak KP; Kleuser B; Huwiler A; Arenz C
Bioorg Med Chem; 2013 Feb; 21(4):874-82. PubMed ID: 23312611
[TBL] [Abstract][Full Text] [Related]
15. Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet beta-cells.
Zhu Q; Shan X; Miao H; Lu Y; Xu J; You N; Liu C; Liao DF; Jin J
FEBS Lett; 2009 Jun; 583(12):2136-41. PubMed ID: 19497324
[TBL] [Abstract][Full Text] [Related]
16. Activity-Based Imaging of Acid Ceramidase in Living Cells.
Ordóñez YF; Abad JL; Aseeri M; Casas J; Garcia V; Casasampere M; Schuchman EH; Levade T; Delgado A; Triola G; Fabrias G
J Am Chem Soc; 2019 May; 141(19):7736-7742. PubMed ID: 31030513
[TBL] [Abstract][Full Text] [Related]
17. The molecular medicine of acid ceramidase.
Frohbergh M; He X; Schuchman EH
Biol Chem; 2015 Jun; 396(6-7):759-65. PubMed ID: 25938220
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands.
Fukaya T; Kodo T; Ishiyama T; Kakuyama H; Nishikawa H; Baba S; Masumoto S
Bioorg Med Chem; 2012 Sep; 20(18):5568-82. PubMed ID: 22884355
[TBL] [Abstract][Full Text] [Related]
19. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity.
Realini N; Solorzano C; Pagliuca C; Pizzirani D; Armirotti A; Luciani R; Costi MP; Bandiera T; Piomelli D
Sci Rep; 2013; 3():1035. PubMed ID: 23301156
[TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors.
Chandrasekharappa AP; Badiger SE; Dubey PK; Panigrahi SK; Manukonda SR
Bioorg Med Chem Lett; 2013 May; 23(9):2579-84. PubMed ID: 23528300
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]