487 related articles for article (PubMed ID: 26581450)
1. Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles.
Zhang J; Doshi U; Suzuki A; Chang CW; Borlak J; Li AP; Tong W
Chem Biol Interact; 2016 Aug; 255():3-11. PubMed ID: 26581450
[TBL] [Abstract][Full Text] [Related]
2. In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries.
Utkarsh D; Loretz C; Li AP
Chem Biol Interact; 2016 Aug; 255():12-22. PubMed ID: 26718876
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse.
Zhang J; He K; Cai L; Chen YC; Yang Y; Shi Q; Woolf TF; Ge W; Guo L; Borlak J; Tong W
Chem Biol Interact; 2016 Aug; 255():45-54. PubMed ID: 27000539
[TBL] [Abstract][Full Text] [Related]
4. Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.
Ware BR; Berger DR; Khetani SR
Toxicol Sci; 2015 Jun; 145(2):252-62. PubMed ID: 25716675
[TBL] [Abstract][Full Text] [Related]
5. Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans.
Atienzar FA; Novik EI; Gerets HH; Parekh A; Delatour C; Cardenas A; MacDonald J; Yarmush ML; Dhalluin S
Toxicol Appl Pharmacol; 2014 Feb; 275(1):44-61. PubMed ID: 24333257
[TBL] [Abstract][Full Text] [Related]
6. Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Sakatis MZ; Reese MJ; Harrell AW; Taylor MA; Baines IA; Chen L; Bloomer JC; Yang EY; Ellens HM; Ambroso JL; Lovatt CA; Ayrton AD; Clarke SE
Chem Res Toxicol; 2012 Oct; 25(10):2067-82. PubMed ID: 22931300
[TBL] [Abstract][Full Text] [Related]
7. Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury.
Goda K; Takahashi T; Kobayashi A; Shoda T; Kuno H; Sugai S
J Toxicol Sci; 2016; 41(5):605-15. PubMed ID: 27665770
[TBL] [Abstract][Full Text] [Related]
8. Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes.
Terelius Y; Figler RA; Marukian S; Collado MS; Lawson MJ; Mackey AJ; Manka D; Qualls CW; Blackman BR; Wamhoff BR; Dash A
Chem Biol Interact; 2016 Aug; 255():31-44. PubMed ID: 26626330
[TBL] [Abstract][Full Text] [Related]
9. Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening.
Gómez-Lechón MJ; Tolosa L
Arch Toxicol; 2016 Sep; 90(9):2049-2061. PubMed ID: 27325232
[TBL] [Abstract][Full Text] [Related]
10. Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay.
Susukida T; Sekine S; Nozaki M; Tokizono M; Ito K
Drug Metab Dispos; 2015 Nov; 43(11):1760-8. PubMed ID: 26329788
[TBL] [Abstract][Full Text] [Related]
11. Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.
Gómez-Lechón MJ; Tolosa L; Donato MT
J Appl Toxicol; 2016 Jun; 36(6):752-68. PubMed ID: 26691983
[TBL] [Abstract][Full Text] [Related]
12. High content analysis assay for prediction of human hepatotoxicity in HepaRG and HepG2 cells.
Saito J; Okamura A; Takeuchi K; Hanioka K; Okada A; Ohata T
Toxicol In Vitro; 2016 Jun; 33():63-70. PubMed ID: 26921665
[TBL] [Abstract][Full Text] [Related]
13. Assessment of mitochondrial dysfunction-related, drug-induced hepatotoxicity in primary rat hepatocytes.
Liu C; Sekine S; Ito K
Toxicol Appl Pharmacol; 2016 Jul; 302():23-30. PubMed ID: 27095095
[TBL] [Abstract][Full Text] [Related]
14. Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions.
Vorrink SU; Zhou Y; Ingelman-Sundberg M; Lauschke VM
Toxicol Sci; 2018 Jun; 163(2):655-665. PubMed ID: 29590495
[TBL] [Abstract][Full Text] [Related]
15. In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties.
Yucha RW; He K; Shi Q; Cai L; Nakashita Y; Xia CQ; Liao M
Toxicol Sci; 2017 Jun; 157(2):487-499. PubMed ID: 28369588
[TBL] [Abstract][Full Text] [Related]
16. Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury.
Xu J; Oda S; Yokoi T
Toxicol In Vitro; 2018 Apr; 48():286-301. PubMed ID: 29407385
[TBL] [Abstract][Full Text] [Related]
17. Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury.
Lin C; Khetani SR
Biomed Res Int; 2016; 2016():1829148. PubMed ID: 27725933
[TBL] [Abstract][Full Text] [Related]
18. The use of hepatocytes to investigate drug toxicity.
Gómez-Lechón MJ; Castell JV; Donato MT
Methods Mol Biol; 2010; 640():389-415. PubMed ID: 20645064
[TBL] [Abstract][Full Text] [Related]
19. Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
Holman NS; Mosedale M; Wolf KK; LeCluyse EL; Watkins PB
Toxicol Sci; 2016 Jun; 151(2):365-75. PubMed ID: 26962055
[TBL] [Abstract][Full Text] [Related]
20. Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats.
Richert L; Baze A; Parmentier C; Gerets HHJ; Sison-Young R; Dorau M; Lovatt C; Czich A; Goldring C; Park BK; Juhila S; Foster AJ; Williams DP
Toxicol Lett; 2016 Sep; 258():207-215. PubMed ID: 27363785
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]