BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

115 related articles for article (PubMed ID: 26581561)

  • 1. Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors.
    Hosaka S; Murayama N; Satsukawa M; Uehara S; Shimizu M; Iwasaki K; Iwano S; Uno Y; Yamazaki H
    Biopharm Drug Dispos; 2016 Jul; 37(5):310-3. PubMed ID: 26581561
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase.
    Hosaka S; Murayama N; Satsukawa M; Uehara S; Shimizu M; Iwasaki K; Iwano S; Uno Y; Yamazaki H
    Drug Metab Dispos; 2015 Jul; 43(7):1119-22. PubMed ID: 25948712
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances.
    Hosaka S; Murayama N; Satsukawa M; Uehara S; Shimizu M; Iwasaki K; Iwano S; Uno Y; Yamazaki H
    Biopharm Drug Dispos; 2015 Dec; 36(9):636-43. PubMed ID: 26348733
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase.
    Hosaka S; Murayama N; Satsukawa M; Shimizu M; Uehara S; Fujino H; Iwasaki K; Iwano S; Uno Y; Yamazaki H
    Drug Metab Dispos; 2015 Jan; 43(1):27-33. PubMed ID: 25318994
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate.
    VandenBrink BM; Foti RS; Rock DA; Wienkers LC; Wahlstrom JL
    Drug Metab Dispos; 2011 Sep; 39(9):1546-54. PubMed ID: 21697463
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparison of p450 enzymes between cynomolgus monkeys and humans: p450 identities, protein contents, kinetic parameters, and potential for inhibitory profiles.
    Emoto C; Yoda N; Uno Y; Iwasaki K; Umehara K; Kashiyama E; Yamazaki H
    Curr Drug Metab; 2013 Feb; 14(2):239-52. PubMed ID: 22963393
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations.
    Filppula AM; Laitila J; Neuvonen PJ; Backman JT
    Drug Metab Dispos; 2011 May; 39(5):904-11. PubMed ID: 21289076
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes.
    Uno Y; Uehara S; Yamazaki H
    Biochem Pharmacol; 2016 Dec; 121():1-7. PubMed ID: 27318253
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole.
    Uno Y; Murayama N; Yamazaki H
    Drug Metab Dispos; 2024 Feb; 52(3):266-273. PubMed ID: 38123944
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans.
    Nishimuta H; Sato K; Mizuki Y; Yabuki M; Komuro S
    Drug Metab Pharmacokinet; 2011 Jun; 26(3):300-6. PubMed ID: 21383522
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Selective inhibition of human cytochrome P4502C8 by montelukast.
    Walsky RL; Obach RS; Gaman EA; Gleeson JP; Proctor WR
    Drug Metab Dispos; 2005 Mar; 33(3):413-8. PubMed ID: 15608135
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?
    Uno Y; Hosaka S; Matsuno K; Nakamura C; Kito G; Kamataki T; Nagata R
    Arch Biochem Biophys; 2007 Oct; 466(1):98-105. PubMed ID: 17689485
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function.
    Uno Y; Iwasaki K; Yamazaki H; Nelson DR
    Drug Metab Rev; 2011 Aug; 43(3):346-61. PubMed ID: 21303270
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans.
    Uno Y; Uehara S; Yamazaki H
    Biochem Pharmacol; 2018 Jul; 153():184-195. PubMed ID: 29277691
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cynomolgus monkey CYPs: a comparison with human CYPs.
    Iwasaki K; Uno Y
    Xenobiotica; 2009 Aug; 39(8):578-81. PubMed ID: 19622000
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Substrate Specificity of Human Cytochrome P450 (CYP) 2C Subfamily and Effect of Azole Antifungal Agents on CYP2C8.
    Niwa T; Imagawa Y
    J Pharm Pharm Sci; 2016; 19(4):423-429. PubMed ID: 28057172
    [TBL] [Abstract][Full Text] [Related]  

  • 17. CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.
    Uno Y; Fujino H; Kito G; Kamataki T; Nagata R
    Mol Pharmacol; 2006 Aug; 70(2):477-86. PubMed ID: 16648389
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone.
    Giri P; Gupta L; Naidu S; Joshi V; Patel N; Giri S; Srinivas NR
    Drug Metab Lett; 2018; 12(2):101-116. PubMed ID: 30117405
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cynomolgus monkey cytochrome P450 2C43: cDNA cloning, heterologous expression, purification and characterization.
    Mitsuda M; Iwasaki M; Asahi S
    J Biochem; 2006 May; 139(5):865-72. PubMed ID: 16751594
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Toward reduction in animal sacrifice for drugs: molecular modeling of Macaca fascicularis P450 2C20 for virtual screening of Homo sapiens P450 2C8 substrates.
    Rua F; Di Nardo G; Sadeghi SJ; Gilardi G
    Biotechnol Appl Biochem; 2012; 59(6):479-89. PubMed ID: 23586958
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.