249 related articles for article (PubMed ID: 26582740)
1. Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.
Kwak SS; Kang KH; Kim S; Lee S; Lee JH; Kim JW; Byun B; Meadows GG; Joe CO
Cell Signal; 2016 Feb; 28(2):32-41. PubMed ID: 26582740
[TBL] [Abstract][Full Text] [Related]
2. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.
Oshiro N; Rapley J; Avruch J
J Biol Chem; 2014 Jan; 289(5):2658-74. PubMed ID: 24337580
[TBL] [Abstract][Full Text] [Related]
3. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Bar-Peled L; Chantranupong L; Cherniack AD; Chen WW; Ottina KA; Grabiner BC; Spear ED; Carter SL; Meyerson M; Sabatini DM
Science; 2013 May; 340(6136):1100-6. PubMed ID: 23723238
[TBL] [Abstract][Full Text] [Related]
4. Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.
Shen K; Valenstein ML; Gu X; Sabatini DM
J Biol Chem; 2019 Feb; 294(8):2970-2975. PubMed ID: 30651352
[TBL] [Abstract][Full Text] [Related]
5. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
Tsun ZY; Bar-Peled L; Chantranupong L; Zoncu R; Wang T; Kim C; Spooner E; Sabatini DM
Mol Cell; 2013 Nov; 52(4):495-505. PubMed ID: 24095279
[TBL] [Abstract][Full Text] [Related]
6. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.
Deng L; Jiang C; Chen L; Jin J; Wei J; Zhao L; Chen M; Pan W; Xu Y; Chu H; Wang X; Ge X; Li D; Liao L; Liu M; Li L; Wang P
Mol Cell; 2015 Jun; 58(5):804-18. PubMed ID: 25936802
[TBL] [Abstract][Full Text] [Related]
7. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Shen K; Huang RK; Brignole EJ; Condon KJ; Valenstein ML; Chantranupong L; Bomaliyamu A; Choe A; Hong C; Yu Z; Sabatini DM
Nature; 2018 Apr; 556(7699):64-69. PubMed ID: 29590090
[TBL] [Abstract][Full Text] [Related]
8. Amino acid regulation of TOR complex 1.
Avruch J; Long X; Ortiz-Vega S; Rapley J; Papageorgiou A; Dai N
Am J Physiol Endocrinol Metab; 2009 Apr; 296(4):E592-602. PubMed ID: 18765678
[TBL] [Abstract][Full Text] [Related]
9. Rag GTPase in amino acid signaling.
Kim J; Kim E
Amino Acids; 2016 Apr; 48(4):915-928. PubMed ID: 26781224
[TBL] [Abstract][Full Text] [Related]
10. Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
Jewell JL; Kim YC; Russell RC; Yu FX; Park HW; Plouffe SW; Tagliabracci VS; Guan KL
Science; 2015 Jan; 347(6218):194-8. PubMed ID: 25567907
[TBL] [Abstract][Full Text] [Related]
11. Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.
Schweitzer LD; Comb WC; Bar-Peled L; Sabatini DM
Cell Rep; 2015 Sep; 12(9):1445-55. PubMed ID: 26299971
[TBL] [Abstract][Full Text] [Related]
12. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.
Lee M; Kim JH; Yoon I; Lee C; Fallahi Sichani M; Kang JS; Kang J; Guo M; Lee KY; Han G; Kim S; Han JM
Proc Natl Acad Sci U S A; 2018 Jun; 115(23):E5279-E5288. PubMed ID: 29784813
[TBL] [Abstract][Full Text] [Related]
13. Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.
Averous J; Lambert-Langlais S; Carraro V; Gourbeyre O; Parry L; B'Chir W; Muranishi Y; Jousse C; Bruhat A; Maurin AC; Proud CG; Fafournoux P
Cell Signal; 2014 Sep; 26(9):1918-27. PubMed ID: 24793303
[TBL] [Abstract][Full Text] [Related]
14. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Sancak Y; Bar-Peled L; Zoncu R; Markhard AL; Nada S; Sabatini DM
Cell; 2010 Apr; 141(2):290-303. PubMed ID: 20381137
[TBL] [Abstract][Full Text] [Related]
15. Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.
Jung J; Genau HM; Behrends C
Mol Cell Biol; 2015 Jul; 35(14):2479-94. PubMed ID: 25963655
[TBL] [Abstract][Full Text] [Related]
16. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.
Shen K; Sabatini DM
Proc Natl Acad Sci U S A; 2018 Sep; 115(38):9545-9550. PubMed ID: 30181260
[TBL] [Abstract][Full Text] [Related]
17. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y; Peterson TR; Shaul YD; Lindquist RA; Thoreen CC; Bar-Peled L; Sabatini DM
Science; 2008 Jun; 320(5882):1496-501. PubMed ID: 18497260
[TBL] [Abstract][Full Text] [Related]
18. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Bar-Peled L; Schweitzer LD; Zoncu R; Sabatini DM
Cell; 2012 Sep; 150(6):1196-208. PubMed ID: 22980980
[TBL] [Abstract][Full Text] [Related]
19. Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.
Wu D; Chapman JR; Wang L; Harris TE; Shabanowitz J; Hunt DF; Fu Z
J Biol Chem; 2012 Apr; 287(15):12510-9. PubMed ID: 22356909
[TBL] [Abstract][Full Text] [Related]
20. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Wang S; Tsun ZY; Wolfson RL; Shen K; Wyant GA; Plovanich ME; Yuan ED; Jones TD; Chantranupong L; Comb W; Wang T; Bar-Peled L; Zoncu R; Straub C; Kim C; Park J; Sabatini BL; Sabatini DM
Science; 2015 Jan; 347(6218):188-94. PubMed ID: 25567906
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]