BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

249 related articles for article (PubMed ID: 26582740)

  • 21. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.
    Jin G; Lee SW; Zhang X; Cai Z; Gao Y; Chou PC; Rezaeian AH; Han F; Wang CY; Yao JC; Gong Z; Chan CH; Huang CY; Tsai FJ; Tsai CH; Tu SH; Wu CH; Sarbassov dos D; Ho YS; Lin HK
    Mol Cell; 2015 Jun; 58(6):989-1000. PubMed ID: 26051179
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
    Peng M; Yin N; Li MO
    Cell; 2014 Sep; 159(1):122-133. PubMed ID: 25259925
    [TBL] [Abstract][Full Text] [Related]  

  • 23. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
    Wolfson RL; Chantranupong L; Wyant GA; Gu X; Orozco JM; Shen K; Condon KJ; Petri S; Kedir J; Scaria SM; Abu-Remaileh M; Frankel WN; Sabatini DM
    Nature; 2017 Mar; 543(7645):438-442. PubMed ID: 28199306
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Regulation of mTORC1 by the Rag GTPases.
    Lama-Sherpa TD; Jeong MH; Jewell JL
    Biochem Soc Trans; 2023 Apr; 51(2):655-664. PubMed ID: 36929165
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Rheb and Rags come together at the lysosome to activate mTORC1.
    Groenewoud MJ; Zwartkruis FJ
    Biochem Soc Trans; 2013 Aug; 41(4):951-5. PubMed ID: 23863162
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Sestrin2 is a leucine sensor for the mTORC1 pathway.
    Wolfson RL; Chantranupong L; Saxton RA; Shen K; Scaria SM; Cantor JR; Sabatini DM
    Science; 2016 Jan; 351(6268):43-8. PubMed ID: 26449471
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.
    Panchaud N; Péli-Gulli MP; De Virgilio C
    Sci Signal; 2013 May; 6(277):ra42. PubMed ID: 23716719
    [TBL] [Abstract][Full Text] [Related]  

  • 28. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.
    Yuan HX; Wang Z; Yu FX; Li F; Russell RC; Jewell JL; Guan KL
    Genes Dev; 2015 Nov; 29(22):2362-76. PubMed ID: 26588989
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Key mediators of intracellular amino acids signaling to mTORC1 activation.
    Duan Y; Li F; Tan K; Liu H; Li Y; Liu Y; Kong X; Tang Y; Wu G; Yin Y
    Amino Acids; 2015 May; 47(5):857-67. PubMed ID: 25701492
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.
    Gong R; Li L; Liu Y; Wang P; Yang H; Wang L; Cheng J; Guan KL; Xu Y
    Genes Dev; 2011 Aug; 25(16):1668-73. PubMed ID: 21816923
    [TBL] [Abstract][Full Text] [Related]  

  • 31. RagD regulates amino acid mediated-casein synthesis and cell proliferation via mTOR signalling in cow mammary epithelial cells.
    Mu Y; Zheng D; Wang C; Yu W; Zhang X
    J Dairy Res; 2018 May; 85(2):204-211. PubMed ID: 29785899
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
    Parmigiani A; Nourbakhsh A; Ding B; Wang W; Kim YC; Akopiants K; Guan KL; Karin M; Budanov AV
    Cell Rep; 2014 Nov; 9(4):1281-91. PubMed ID: 25457612
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.
    Chantranupong L; Wolfson RL; Orozco JM; Saxton RA; Scaria SM; Bar-Peled L; Spooner E; Isasa M; Gygi SP; Sabatini DM
    Cell Rep; 2014 Oct; 9(1):1-8. PubMed ID: 25263562
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
    Efeyan A; Zoncu R; Chang S; Gumper I; Snitkin H; Wolfson RL; Kirak O; Sabatini DD; Sabatini DM
    Nature; 2013 Jan; 493(7434):679-83. PubMed ID: 23263183
    [TBL] [Abstract][Full Text] [Related]  

  • 35. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
    Agarwal S; Bell CM; Taylor SM; Moran RG
    Mol Cancer Res; 2016 Jan; 14(1):66-77. PubMed ID: 26385560
    [TBL] [Abstract][Full Text] [Related]  

  • 36. RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121.
    Sekiguchi T; Furuno N; Ishii T; Hirose E; Sekiguchi F; Wang Y; Kobayashi H
    Genes Cells; 2019 Feb; 24(2):151-161. PubMed ID: 30570184
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.
    Petit CS; Roczniak-Ferguson A; Ferguson SM
    J Cell Biol; 2013 Sep; 202(7):1107-22. PubMed ID: 24081491
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.
    Ögmundsdóttir MH; Heublein S; Kazi S; Reynolds B; Visvalingam SM; Shaw MK; Goberdhan DC
    PLoS One; 2012; 7(5):e36616. PubMed ID: 22574197
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.
    Dennis MD; Baum JI; Kimball SR; Jefferson LS
    J Biol Chem; 2011 Mar; 286(10):8287-8296. PubMed ID: 21239491
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.
    Demetriades C; Doumpas N; Teleman AA
    Cell; 2014 Feb; 156(4):786-99. PubMed ID: 24529380
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.