159 related articles for article (PubMed ID: 26598462)
1. Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists.
Vu HN; Kim JY; Hassan AH; Choi K; Park JH; Park KD; Lee JK; Pae AN; Choo H; Min SJ; Cho YS
Bioorg Med Chem Lett; 2016 Jan; 26(1):140-4. PubMed ID: 26598462
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists.
Xi N; Bo Y; Doherty EM; Fotsch C; Gavva NR; Han N; Hungate RW; Klionsky L; Liu Q; Tamir R; Xu S; Treanor JJ; Norman MH
Bioorg Med Chem Lett; 2005 Dec; 15(23):5211-7. PubMed ID: 16203144
[TBL] [Abstract][Full Text] [Related]
3. Synthesis, Biological Evaluation and Docking Studies of Sorafenib Derivatives N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-4(5)-phenylpicolinamides.
Wang M; Wu C; Xu S; Zhu Y; Li W; Zheng P; Zhu W
Med Chem; 2017; 13(2):176-185. PubMed ID: 27855595
[TBL] [Abstract][Full Text] [Related]
4. Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.
Packiarajan M; Grenon M; Zorn S; Hopper AT; White AD; Chandrasena G; Pu X; Brodbeck RM; Robichaud AJ
Bioorg Med Chem Lett; 2013 Jul; 23(14):4037-43. PubMed ID: 23770058
[TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.
Kulkarni SS; Nightingale B; Dersch CM; Rothman RB; Newman AH
Bioorg Med Chem Lett; 2006 Jul; 16(13):3371-5. PubMed ID: 16678408
[TBL] [Abstract][Full Text] [Related]
6. 2-(3'-Indolyl)-N-arylthiazole-4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activities.
Tantak MP; Wang J; Singh RP; Kumar A; Shah K; Kumar D
Bioorg Med Chem Lett; 2015 Oct; 25(19):4225-31. PubMed ID: 26298501
[TBL] [Abstract][Full Text] [Related]
7. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).
Turlington M; Noetzel MJ; Chun A; Zhou Y; Gogliotti RD; Nguyen ED; Gregory KJ; Vinson PN; Rook JM; Gogi KK; Xiang Z; Bridges TM; Daniels JS; Jones C; Niswender CM; Meiler J; Conn PJ; Lindsley CW; Stauffer SR
J Med Chem; 2013 Oct; 56(20):7976-96. PubMed ID: 24050755
[TBL] [Abstract][Full Text] [Related]
8. Docking, Molecular Dynamics Simulation and Synthesis of New Fenobam Analogues as mGlu5 Receptor Antagonists.
Javidan A; Taghizadeh MJ; Hosseini SA; Iman M; Jafari R
Comb Chem High Throughput Screen; 2016; 19(9):764-770. PubMed ID: 27585831
[TBL] [Abstract][Full Text] [Related]
9. Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
Felts AS; Bollinger KA; Brassard CJ; Rodriguez AL; Morrison RD; Scott Daniels J; Blobaum AL; Niswender CM; Jones CK; Conn PJ; Emmitte KA; Lindsley CW
Bioorg Med Chem Lett; 2019 Jan; 29(1):47-50. PubMed ID: 30446311
[TBL] [Abstract][Full Text] [Related]
10. 7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5.
Topiol S; Sabio M
Bioorg Med Chem Lett; 2016 Jan; 26(2):484-494. PubMed ID: 26706173
[TBL] [Abstract][Full Text] [Related]
11. New thiazole carboxamides as potent inhibitors of Akt kinases.
Chang S; Zhang Z; Zhuang X; Luo J; Cao X; Li H; Tu Z; Lu X; Ren X; Ding K
Bioorg Med Chem Lett; 2012 Jan; 22(2):1208-12. PubMed ID: 22172705
[TBL] [Abstract][Full Text] [Related]
12. Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.
Chen P; Norris D; Das J; Spergel SH; Wityak J; Leith L; Zhao R; Chen BC; Pitt S; Pang S; Shen DR; Zhang R; De Fex HF; Doweyko AM; McIntyre KW; Shuster DJ; Behnia K; Schieven GL; Barrish JC
Bioorg Med Chem Lett; 2004 Dec; 14(24):6061-6. PubMed ID: 15546730
[TBL] [Abstract][Full Text] [Related]
13. 3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity.
Fisher MJ; Backer RT; Barth VN; Garbison KE; Gruber JM; Heinz BA; Iyengar S; Hollinshead SP; Kingston A; Kuklish SL; Li L; Nisenbaum ES; Peters SC; Phebus L; Simmons RM; van der Aar E
Bioorg Med Chem Lett; 2012 Apr; 22(7):2514-7. PubMed ID: 22386665
[TBL] [Abstract][Full Text] [Related]
14. Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4).
Gogliotti RD; Blobaum AL; Morrison RM; Daniels JS; Salovich JM; Cheung YY; Rodriguez AL; Loch MT; Conn PJ; Lindsley CW; Niswender CM; Hopkins CR
Bioorg Med Chem Lett; 2016 Jul; 26(13):2984-2987. PubMed ID: 27234146
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, docking and biological evaluation of 4-phenyl-thiazole derivatives as autotaxin (ATX) inhibitors.
Balupuri A; Lee DY; Lee MH; Chae S; Jung E; Kim Y; Ryu J; Kang NS
Bioorg Med Chem Lett; 2017 Sep; 27(17):4156-4164. PubMed ID: 28743508
[TBL] [Abstract][Full Text] [Related]
16. Comparative in vitro studies of MR imaging probes for metabotropic glutamate subtype-5 receptor targeting.
Gottschalk S; Engelmann J; Rolla GA; Botta M; Parker D; Mishra A
Org Biomol Chem; 2013 Sep; 11(36):6131-41. PubMed ID: 23925571
[TBL] [Abstract][Full Text] [Related]
17. Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
Bates BS; Rodriguez AL; Felts AS; Morrison RD; Venable DF; Blobaum AL; Byers FW; Lawson KP; Daniels JS; Niswender CM; Jones CK; Conn PJ; Lindsley CW; Emmitte KA
Bioorg Med Chem Lett; 2014 Aug; 24(15):3307-14. PubMed ID: 24969015
[TBL] [Abstract][Full Text] [Related]
18. Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators.
Chae E; Shin YJ; Ryu EJ; Ji MK; Ryune Cho N; Lee KH; Jeong HJ; Kim SJ; Choi Y; Seok Oh K; Park CE; Soo Yoon Y
Bioorg Med Chem Lett; 2013 Apr; 23(7):2134-9. PubMed ID: 23434029
[TBL] [Abstract][Full Text] [Related]
19. Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.
Kulkarni SS; Zou MF; Cao J; Deschamps JR; Rodriguez AL; Conn PJ; Newman AH
J Med Chem; 2009 Jun; 52(11):3563-75. PubMed ID: 19445453
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain.
Son MH; Kim JY; Lim EJ; Baek DJ; Choi K; Lee JK; Pae AN; Min SJ; Cho YS
Bioorg Med Chem Lett; 2013 Mar; 23(5):1472-6. PubMed ID: 23333207
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
