144 related articles for article (PubMed ID: 26602278)
1. Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study.
Kim M; Lee S; Park EB; Kim KJ; Lee HH; Shin JS; Fischer K; Koeberle A; Werz O; Lee KT; Lee JY
Bioorg Med Chem Lett; 2016 Jan; 26(1):94-9. PubMed ID: 26602278
[TBL] [Abstract][Full Text] [Related]
2. Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents.
Park EB; Kim KJ; Jeong HR; Lee JK; Kim HJ; Lee HH; Lim JW; Shin JS; Koeberle A; Werz O; Lee KT; Lee JY
Bioorg Med Chem Lett; 2016 Nov; 26(21):5193-5197. PubMed ID: 27720548
[TBL] [Abstract][Full Text] [Related]
3. Identification of novel mPGES-1 inhibitors through screening of a chemical library.
Park SJ; Han SG; Ahsan HM; Lee K; Lee JY; Shin JS; Lee KT; Kang NS; Yu YG
Bioorg Med Chem Lett; 2012 Dec; 22(24):7335-9. PubMed ID: 23147075
[TBL] [Abstract][Full Text] [Related]
4. Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E
Kim M; Kim G; Kang M; Ko D; Nam Y; Moon CS; Kang HM; Shin JS; Werz O; Lee KT; Lee JY
Bioorg Med Chem Lett; 2021 Jun; 41():127992. PubMed ID: 33775835
[TBL] [Abstract][Full Text] [Related]
5. Novel benzoxazole inhibitors of mPGES-1.
Kablaoui N; Patel S; Shao J; Demian D; Hoffmaster K; Berlioz F; Vazquez ML; Moore WM; Nugent RA
Bioorg Med Chem Lett; 2013 Feb; 23(3):907-11. PubMed ID: 23266122
[TBL] [Abstract][Full Text] [Related]
6. Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1).
Lauro G; Strocchia M; Terracciano S; Bruno I; Fischer K; Pergola C; Werz O; Riccio R; Bifulco G
Eur J Med Chem; 2014 Jun; 80():407-15. PubMed ID: 24794772
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.
Walker DP; Arhancet GB; Lu HF; Heasley SE; Metz S; Kablaoui NM; Franco FM; Hanau CE; Scholten JA; Springer JR; Fobian YM; Carter JS; Xing L; Yang S; Shaffer AF; Jerome GM; Baratta MT; Moore WM; Vazquez ML
Bioorg Med Chem Lett; 2013 Feb; 23(4):1120-6. PubMed ID: 23298810
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.
Hanke T; Rörsch F; Thieme TM; Ferreiros N; Schneider G; Geisslinger G; Proschak E; Grösch S; Schubert-Zsilavecz M
Bioorg Med Chem; 2013 Dec; 21(24):7874-83. PubMed ID: 24183739
[TBL] [Abstract][Full Text] [Related]
9. Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid.
Lee K; Pham VC; Choi MJ; Kim KJ; Lee KT; Han SG; Yu YG; Lee JY
Bioorg Med Chem Lett; 2013 Jan; 23(1):75-80. PubMed ID: 23218602
[TBL] [Abstract][Full Text] [Related]
10. Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
Arhancet GB; Walker DP; Metz S; Fobian YM; Heasley SE; Carter JS; Springer JR; Jones DE; Hayes MJ; Shaffer AF; Jerome GM; Baratta MT; Zweifel B; Moore WM; Masferrer JL; Vazquez ML
Bioorg Med Chem Lett; 2013 Feb; 23(4):1114-9. PubMed ID: 23260349
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of prostaglandin E(2) production by synthetic minor prenylated chalcones and flavonoids: synthesis, biological activity, crystal structure, and in silico evaluation.
Rullah K; Mohd Aluwi MF; Yamin BM; Abdul Bahari MN; Wei LS; Ahmad S; Abas F; Ismail NH; Jantan I; Wai LK
Bioorg Med Chem Lett; 2014 Aug; 24(16):3826-34. PubMed ID: 25027933
[TBL] [Abstract][Full Text] [Related]
12. Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen.
He S; Li C; Liu Y; Lai L
J Med Chem; 2013 Apr; 56(8):3296-309. PubMed ID: 23527738
[TBL] [Abstract][Full Text] [Related]
13. Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.
De Simone R; Bruno I; Riccio R; Stadler K; Bauer J; Schaible AM; Laufer S; Werz O
Bioorg Med Chem; 2012 Aug; 20(16):5012-6. PubMed ID: 22795900
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and PGE₂ production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells.
Kang SM; Lee J; Jin JH; Kim M; Lee S; Lee HH; Shin JS; Lee KT; Lee JY
Bioorg Med Chem Lett; 2014 Dec; 24(23):5418-22. PubMed ID: 25453800
[TBL] [Abstract][Full Text] [Related]
15. Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E(2) synthase-1 inhibitors.
Banerjee A; Pawar MY; Patil S; Yadav PS; Kadam PA; Kattige VG; Deshpande DS; Pednekar PV; Pisat MK; Gharat LA
Bioorg Med Chem Lett; 2014 Oct; 24(20):4838-44. PubMed ID: 25260492
[TBL] [Abstract][Full Text] [Related]
16. Molecular docking and competitive binding study discovered different binding modes of microsomal prostaglandin E synthase-1 inhibitors.
He S; Lai L
J Chem Inf Model; 2011 Dec; 51(12):3254-61. PubMed ID: 22077876
[TBL] [Abstract][Full Text] [Related]
17. Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template.
Wang J; Limburg D; Carter J; Mbalaviele G; Gierse J; Vazquez M
Bioorg Med Chem Lett; 2010 Mar; 20(5):1604-9. PubMed ID: 20144869
[TBL] [Abstract][Full Text] [Related]
18. Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production.
Ikeda-Matsuo Y; Ikegaya Y; Matsuki N; Uematsu S; Akira S; Sasaki Y
J Neurochem; 2005 Sep; 94(6):1546-58. PubMed ID: 16000148
[TBL] [Abstract][Full Text] [Related]
19. Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.
Koeberle A; Werz O
Biochem Pharmacol; 2015 Nov; 98(1):1-15. PubMed ID: 26123522
[TBL] [Abstract][Full Text] [Related]
20. Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
Riendeau D; Aspiotis R; Ethier D; Gareau Y; Grimm EL; Guay J; Guiral S; Juteau H; Mancini JA; Méthot N; Rubin J; Friesen RW
Bioorg Med Chem Lett; 2005 Jul; 15(14):3352-5. PubMed ID: 15953724
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]