BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 26606751)

  • 1. Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction.
    Rose AS; Zachariae U; Grubmüller H; Hofmann KP; Scheerer P; Hildebrand PW
    PLoS One; 2015; 10(11):e0143399. PubMed ID: 26606751
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.
    Oldham WM; Van Eps N; Preininger AM; Hubbell WL; Hamm HE
    Nat Struct Mol Biol; 2006 Sep; 13(9):772-7. PubMed ID: 16892066
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface.
    Scheerer P; Heck M; Goede A; Park JH; Choe HW; Ernst OP; Hofmann KP; Hildebrand PW
    Proc Natl Acad Sci U S A; 2009 Jun; 106(26):10660-5. PubMed ID: 19541654
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The receptor-bound "empty pocket" state of the heterotrimeric G-protein alpha-subunit is conformationally dynamic.
    Abdulaev NG; Ngo T; Ramon E; Brabazon DM; Marino JP; Ridge KD
    Biochemistry; 2006 Oct; 45(43):12986-97. PubMed ID: 17059215
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular dynamics simulations of the effect of the G-protein and diffusible ligands on the β2-adrenergic receptor.
    Goetz A; Lanig H; Gmeiner P; Clark T
    J Mol Biol; 2011 Dec; 414(4):611-23. PubMed ID: 22037586
    [TBL] [Abstract][Full Text] [Related]  

  • 6. GDP Release from the Open Conformation of Gα Requires Allosteric Signaling from the Agonist-Bound Human β
    Kumar V; Hoag H; Sader S; Scorese N; Liu H; Wu C
    J Chem Inf Model; 2020 Aug; 60(8):4064-4075. PubMed ID: 32786510
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit.
    Kaya AI; Lokits AD; Gilbert JA; Iverson TM; Meiler J; Hamm HE
    J Biol Chem; 2014 Aug; 289(35):24475-87. PubMed ID: 25037222
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins.
    Kapoor N; Menon ST; Chauhan R; Sachdev P; Sakmar TP
    J Mol Biol; 2009 Nov; 393(4):882-97. PubMed ID: 19703466
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding.
    Goricanec D; Stehle R; Egloff P; Grigoriu S; Plückthun A; Wagner G; Hagn F
    Proc Natl Acad Sci U S A; 2016 Jun; 113(26):E3629-38. PubMed ID: 27298341
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The carboxyl terminus of the Galpha-subunit is the latch for triggered activation of heterotrimeric G proteins.
    Nanoff C; Koppensteiner R; Yang Q; Fuerst E; Ahorn H; Freissmuth M
    Mol Pharmacol; 2006 Jan; 69(1):397-405. PubMed ID: 16210429
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model.
    Kim MH; Kim YJ; Kim HR; Jeon TJ; Choi JB; Chung KY; Kim MK
    PLoS One; 2016; 11(8):e0159528. PubMed ID: 27483005
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A G protein-coupled receptor at work: the rhodopsin model.
    Hofmann KP; Scheerer P; Hildebrand PW; Choe HW; Park JH; Heck M; Ernst OP
    Trends Biochem Sci; 2009 Nov; 34(11):540-52. PubMed ID: 19836958
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
    Preininger AM; Funk MA; Oldham WM; Meier SM; Johnston CA; Adhikary S; Kimple AJ; Siderovski DP; Hamm HE; Iverson TM
    Biochemistry; 2009 Mar; 48(12):2630-42. PubMed ID: 19222191
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.
    Chung KY; Rasmussen SG; Liu T; Li S; DeVree BT; Chae PS; Calinski D; Kobilka BK; Woods VL; Sunahara RK
    Nature; 2011 Sep; 477(7366):611-5. PubMed ID: 21956331
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.
    Seifert R; Wenzel-Seifert K; Gether U; Kobilka BK
    J Pharmacol Exp Ther; 2001 Jun; 297(3):1218-26. PubMed ID: 11356949
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor.
    Kaya AI; Lokits AD; Gilbert JA; Iverson TM; Meiler J; Hamm HE
    J Biol Chem; 2016 Sep; 291(37):19674-86. PubMed ID: 27462082
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dissociation of membrane-anchored heterotrimeric G-protein induced by G(α) subunit binding to GTP.
    Louet M; Charlier L; Martinez J; Floquet N
    J Chem Inf Model; 2012 Nov; 52(11):3022-7. PubMed ID: 23094679
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.
    Kalogriopoulos NA; Rees SD; Ngo T; Kopcho NJ; Ilatovskiy AV; Sun N; Komives EA; Chang G; Ghosh P; Kufareva I
    Proc Natl Acad Sci U S A; 2019 Aug; 116(33):16394-16403. PubMed ID: 31363053
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Time-resolved cryo-EM of G-protein activation by a GPCR.
    Papasergi-Scott MM; Pérez-Hernández G; Batebi H; Gao Y; Eskici G; Seven AB; Panova O; Hilger D; Casiraghi M; He F; Maul L; Gmeiner P; Kobilka BK; Hildebrand PW; Skiniotis G
    Nature; 2024 May; 629(8014):1182-1191. PubMed ID: 38480881
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Interactions of the α-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: a critical review and analysis of interacting surfaces, conformational shifts, structural diversity and electrostatic potentials.
    Baltoumas FA; Theodoropoulou MC; Hamodrakas SJ
    J Struct Biol; 2013 Jun; 182(3):209-18. PubMed ID: 23523730
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.