BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

171 related articles for article (PubMed ID: 26608299)

  • 21. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
    Jain A; Lamark T; Sjøttem E; Larsen KB; Awuh JA; Øvervatn A; McMahon M; Hayes JD; Johansen T
    J Biol Chem; 2010 Jul; 285(29):22576-91. PubMed ID: 20452972
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex.
    Baird L; Llères D; Swift S; Dinkova-Kostova AT
    Proc Natl Acad Sci U S A; 2013 Sep; 110(38):15259-64. PubMed ID: 23986495
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
    Shibata T; Ohta T; Tong KI; Kokubu A; Odogawa R; Tsuta K; Asamura H; Yamamoto M; Hirohashi S
    Proc Natl Acad Sci U S A; 2008 Sep; 105(36):13568-73. PubMed ID: 18757741
    [TBL] [Abstract][Full Text] [Related]  

  • 24. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A; Motohashi H
    Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
    [TBL] [Abstract][Full Text] [Related]  

  • 25. New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.
    Cheng L; Wang H; Li S; Liu Z; Wang C
    Life Sci; 2021 Oct; 282():119791. PubMed ID: 34229009
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
    Taguchi K; Motohashi H; Yamamoto M
    Genes Cells; 2011 Feb; 16(2):123-40. PubMed ID: 21251164
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.
    Singh A; Misra V; Thimmulappa RK; Lee H; Ames S; Hoque MO; Herman JG; Baylin SB; Sidransky D; Gabrielson E; Brock MV; Biswal S
    PLoS Med; 2006 Oct; 3(10):e420. PubMed ID: 17020408
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The emerging role of the Nrf2-Keap1 signaling pathway in cancer.
    Jaramillo MC; Zhang DD
    Genes Dev; 2013 Oct; 27(20):2179-91. PubMed ID: 24142871
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.
    Tanigawa S; Fujii M; Hou DX
    Free Radic Biol Med; 2007 Jun; 42(11):1690-703. PubMed ID: 17462537
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Cysteine-based regulation of the CUL3 adaptor protein Keap1.
    Sekhar KR; Rachakonda G; Freeman ML
    Toxicol Appl Pharmacol; 2010 Apr; 244(1):21-6. PubMed ID: 19560482
    [TBL] [Abstract][Full Text] [Related]  

  • 31. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.
    Hayes JD; McMahon M
    Trends Biochem Sci; 2009 Apr; 34(4):176-88. PubMed ID: 19321346
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Development of a High-Throughput Cul3-Keap1 Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Identifying Nrf2 Activators.
    Poore DD; Hofmann G; Wolfe LA; Qi H; Jiang M; Fischer M; Wu Z; Sweitzer TD; Chakravorty S; Donovan B; Li H
    SLAS Discov; 2019 Feb; 24(2):175-189. PubMed ID: 30383469
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response.
    Zhang Y; Hou Y; Liu C; Li Y; Guo W; Wu JL; Xu D; You X; Pan Y; Chen Y
    Free Radic Biol Med; 2016 Aug; 97():38-49. PubMed ID: 27212020
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases.
    Pallesen JS; Tran KT; Bach A
    J Med Chem; 2018 Sep; 61(18):8088-8103. PubMed ID: 29750408
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode.
    Georgakopoulos N; Talapatra S; Dikovskaya D; Dayalan Naidu S; Higgins M; Gatliff J; Ayhan A; Nikoloudaki R; Schaap M; Valko K; Javid F; Dinkova-Kostova AT; Kozielski F; Wells G
    J Med Chem; 2022 May; 65(10):7380-7398. PubMed ID: 35549469
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells.
    Yang SP; Yang XZ; Cao GP
    Mol Med Rep; 2015 Jul; 12(1):1145-50. PubMed ID: 25776802
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2).
    Wong DP; Wells G; Hagen T
    Eur J Pharmacol; 2010 Sep; 643(2-3):188-94. PubMed ID: 20599909
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.
    He X; Ma Q
    J Pharmacol Exp Ther; 2010 Jan; 332(1):66-75. PubMed ID: 19808700
    [TBL] [Abstract][Full Text] [Related]  

  • 39. [Prothyomosin alpha interaction with KEAP1 doesn't lead to prothymosin alpha ubiquination and degradation].
    Mel'nikov SV; Evstaf'eva AG; Vartapetian AB
    Mol Biol (Mosk); 2007; 41(5):868-75. PubMed ID: 18240569
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
    Ortet PC; Muellers SN; Viarengo-Baker LA; Streu K; Szymczyna BR; Beeler AB; Allen KN; Whitty A
    J Am Chem Soc; 2021 Mar; 143(10):3779-3793. PubMed ID: 33683866
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.