142 related articles for article (PubMed ID: 26608390)
1. Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin.
Brautigam H; Moreno CL; Steele JW; Bogush A; Dickstein DL; Kwok JB; Schofield PR; Thinakaran G; Mathews PM; Hof PR; Gandy S; Ehrlich ME
Sci Rep; 2015 Nov; 5():17042. PubMed ID: 26608390
[TBL] [Abstract][Full Text] [Related]
2. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Heilig EA; Xia W; Shen J; Kelleher RJ
J Biol Chem; 2010 Jul; 285(29):22350-9. PubMed ID: 20460383
[TBL] [Abstract][Full Text] [Related]
3. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
4. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
[TBL] [Abstract][Full Text] [Related]
5. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
[TBL] [Abstract][Full Text] [Related]
6. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
Cacquevel M; Aeschbach L; Houacine J; Fraering PC
PLoS One; 2012; 7(4):e35133. PubMed ID: 22529981
[TBL] [Abstract][Full Text] [Related]
7. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
[TBL] [Abstract][Full Text] [Related]
8. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
[TBL] [Abstract][Full Text] [Related]
9. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
Kuzuya A; Uemura K; Kitagawa N; Aoyagi N; Kihara T; Ninomiya H; Ishiura S; Takahashi R; Shimohama S
J Neurosci Res; 2007 Jan; 85(1):153-65. PubMed ID: 17075903
[TBL] [Abstract][Full Text] [Related]
10. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
[TBL] [Abstract][Full Text] [Related]
11. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.
Verdile G; Groth D; Mathews PM; St George-Hyslop P; Fraser PE; Ramabhadran TV; Kwok JB; Schofield PR; Carter T; Gandy S; Martins RN
Mol Psychiatry; 2004 Jun; 9(6):594-602. PubMed ID: 14993906
[TBL] [Abstract][Full Text] [Related]
12. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.
Leroy K; Ando K; Laporte V; Dedecker R; Suain V; Authelet M; Héraud C; Pierrot N; Yilmaz Z; Octave JN; Brion JP
Am J Pathol; 2012 Dec; 181(6):1928-40. PubMed ID: 23026200
[TBL] [Abstract][Full Text] [Related]
13. Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.
Sesele K; Thanopoulou K; Paouri E; Tsefou E; Klinakis A; Georgopoulos S
Aging Cell; 2013 Dec; 12(6):1032-40. PubMed ID: 23826707
[TBL] [Abstract][Full Text] [Related]
14. Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production.
Heilig EA; Gutti U; Tai T; Shen J; Kelleher RJ
J Neurosci; 2013 Jul; 33(28):11606-17. PubMed ID: 23843529
[TBL] [Abstract][Full Text] [Related]
15. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
[TBL] [Abstract][Full Text] [Related]
16. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.
Berezovska O; Lleo A; Herl LD; Frosch MP; Stern EA; Bacskai BJ; Hyman BT
J Neurosci; 2005 Mar; 25(11):3009-17. PubMed ID: 15772361
[TBL] [Abstract][Full Text] [Related]
17. Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.
Li T; Li YM; Ahn K; Price DL; Sisodia SS; Wong PC
PLoS One; 2011; 6(11):e28179. PubMed ID: 22140537
[TBL] [Abstract][Full Text] [Related]
18. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
Brijbassi S; Amtul Z; Newbigging S; Westaway D; St George-Hyslop P; Rozmahel RF
Neurobiol Dis; 2007 Feb; 25(2):291-6. PubMed ID: 17071095
[TBL] [Abstract][Full Text] [Related]
19. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
Kumar VB; Franko M; Banks WA; Kasinadhuni P; Farr SA; Vyas K; Choudhuri V; Morley JE
J Exp Biol; 2009 Feb; 212(Pt 4):494-8. PubMed ID: 19181896
[TBL] [Abstract][Full Text] [Related]
20. Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.
Ryazantseva M; Skobeleva K; Glushankova L; Kaznacheyeva E
J Neurochem; 2016 Mar; 136(5):1085-95. PubMed ID: 26678016
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
