BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

99 related articles for article (PubMed ID: 26645570)

  • 1. Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization.
    Al-Eisawi Z; Stefani C; Jansson PJ; Arvind A; Sharpe PC; Basha MT; Iskander GM; Kumar N; Kovacevic Z; Lane DJ; Sahni S; Bernhardt PV; Richardson DR; Kalinowski DS
    J Med Chem; 2016 Jan; 59(1):294-312. PubMed ID: 26645570
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization.
    Stefani C; Al-Eisawi Z; Jansson PJ; Kalinowski DS; Richardson DR
    J Inorg Biochem; 2015 Nov; 152():20-37. PubMed ID: 26335599
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
    Richardson DR; Kalinowski DS; Richardson V; Sharpe PC; Lovejoy DB; Islam M; Bernhardt PV
    J Med Chem; 2009 Mar; 52(5):1459-70. PubMed ID: 19216562
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor activity.
    Jansson PJ; Sharpe PC; Bernhardt PV; Richardson DR
    J Med Chem; 2010 Aug; 53(15):5759-69. PubMed ID: 20597487
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
    Kalinowski DS; Yu Y; Sharpe PC; Islam M; Liao YT; Lovejoy DB; Kumar N; Bernhardt PV; Richardson DR
    J Med Chem; 2007 Jul; 50(15):3716-29. PubMed ID: 17602603
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation.
    Stefani C; Jansson PJ; Gutierrez E; Bernhardt PV; Richardson DR; Kalinowski DS
    J Med Chem; 2013 Jan; 56(1):357-70. PubMed ID: 23276209
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect.
    Quach P; Gutierrez E; Basha MT; Kalinowski DS; Sharpe PC; Lovejoy DB; Bernhardt PV; Jansson PJ; Richardson DR
    Mol Pharmacol; 2012 Jul; 82(1):105-14. PubMed ID: 22508546
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
    Stefani C; Punnia-Moorthy G; Lovejoy DB; Jansson PJ; Kalinowski DS; Sharpe PC; Bernhardt PV; Richardson DR
    J Med Chem; 2011 Oct; 54(19):6936-48. PubMed ID: 21846118
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance.
    Stacy AE; Palanimuthu D; Bernhardt PV; Kalinowski DS; Jansson PJ; Richardson DR
    J Med Chem; 2016 Sep; 59(18):8601-20. PubMed ID: 27524608
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes.
    Lovejoy DB; Jansson PJ; Brunk UT; Wong J; Ponka P; Richardson DR
    Cancer Res; 2011 Sep; 71(17):5871-80. PubMed ID: 21750178
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, characterization and biological activities of semicarbazones and their copper complexes.
    Venkatachalam TK; Bernhardt PV; Noble CJ; Fletcher N; Pierens GK; Thurecht KJ; Reutens DC
    J Inorg Biochem; 2016 Sep; 162():295-308. PubMed ID: 27138101
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites.
    Potůčková E; Roh J; Macháček M; Sahni S; Stariat J; Šesták V; Jansová H; Hašková P; Jirkovská A; Vávrová K; Kovaříková P; Kalinowski DS; Richardson DR; Šimůnek T
    PLoS One; 2015; 10(10):e0139929. PubMed ID: 26460540
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy.
    Lukmantara AY; Kalinowski DS; Kumar N; Richardson DR
    J Inorg Biochem; 2014 Dec; 141():43-54. PubMed ID: 25217717
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity.
    Richardson DR; Sharpe PC; Lovejoy DB; Senaratne D; Kalinowski DS; Islam M; Bernhardt PV
    J Med Chem; 2006 Nov; 49(22):6510-21. PubMed ID: 17064069
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
    Lovejoy DB; Sharp DM; Seebacher N; Obeidy P; Prichard T; Stefani C; Basha MT; Sharpe PC; Jansson PJ; Kalinowski DS; Bernhardt PV; Richardson DR
    J Med Chem; 2012 Aug; 55(16):7230-44. PubMed ID: 22861499
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC.
    Seebacher NA; Richardson DR; Jansson PJ
    Cell Death Dis; 2016 Dec; 7(12):e2510. PubMed ID: 27906178
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity.
    Stacy AE; Palanimuthu D; Bernhardt PV; Kalinowski DS; Jansson PJ; Richardson DR
    J Med Chem; 2016 May; 59(10):4965-84. PubMed ID: 27023111
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity.
    Opletalová V; Kalinowski DS; Vejsová M; Kunes J; Pour M; Jampílek J; Buchta V; Richardson DR
    Chem Res Toxicol; 2008 Sep; 21(9):1878-89. PubMed ID: 18698850
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effect of N(4)-phenyl substitution in 2-oxo-1,2-dihydroquinoline-3-carbaldehyde semicarbazones on the structure, DNA/protein interaction, and antioxidative and cytotoxic activity of Cu(II) complexes.
    Raja DS; Bhuvanesh NS; Natarajan K
    Inorg Chem; 2011 Dec; 50(24):12852-66. PubMed ID: 22074239
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.
    Yu Y; Suryo Rahmanto Y; Hawkins CL; Richardson DR
    Mol Pharmacol; 2011 Jun; 79(6):921-31. PubMed ID: 21389104
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.