206 related articles for article (PubMed ID: 26645732)
1. Synthesis and Structure-Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors.
Singh A; Kast J; Dirain ML; Huang H; Haskell-Luevano C
ACS Chem Neurosci; 2016 Feb; 7(2):196-205. PubMed ID: 26645732
[TBL] [Abstract][Full Text] [Related]
2. Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).
Singh A; Dirain ML; Wilczynski A; Chen C; Gosnell BA; Levine AS; Edison AS; Haskell-Luevano C
ACS Chem Neurosci; 2014 Oct; 5(10):1020-31. PubMed ID: 25141170
[TBL] [Abstract][Full Text] [Related]
3. Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[beta-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 peptide template.
Wilczynski A; Wilson KR; Scott JW; Edison AS; Haskell-Luevano C
J Med Chem; 2005 Apr; 48(8):3060-75. PubMed ID: 15828845
[TBL] [Abstract][Full Text] [Related]
4. Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
Wilczynski A; Wang XS; Joseph CG; Xiang Z; Bauzo RM; Scott JW; Sorensen NB; Shaw AM; Millard WJ; Richards NG; Haskell-Luevano C
J Med Chem; 2004 Apr; 47(9):2194-207. PubMed ID: 15084118
[TBL] [Abstract][Full Text] [Related]
5. Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position.
Holder JR; Bauzo RM; Xiang Z; Haskell-Luevano C
J Med Chem; 2002 Jun; 45(13):2801-10. PubMed ID: 12061882
[TBL] [Abstract][Full Text] [Related]
6. γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R.
Joseph CG; Yao H; Scott JW; Sorensen NB; Marnane RN; Mountjoy KG; Haskell-Luevano C
Peptides; 2010 Dec; 31(12):2304-13. PubMed ID: 20833220
[TBL] [Abstract][Full Text] [Related]
7. Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity.
Proneth B; Pogozheva ID; Portillo FP; Mosberg HI; Haskell-Luevano C
J Med Chem; 2008 Sep; 51(18):5585-93. PubMed ID: 18800761
[TBL] [Abstract][Full Text] [Related]
8. Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists.
Fleming KA; Freeman KT; Ericson MD; Haskell-Luevano C
J Med Chem; 2018 Sep; 61(17):7729-7740. PubMed ID: 30035543
[TBL] [Abstract][Full Text] [Related]
9. Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μM MC4R Partial Agonist.
Fleming KA; Freeman KT; Powers MD; Santos RG; Debevec G; Giulianotti MA; Houghten RA; Doering SR; Pinilla C; Haskell-Luevano C
J Med Chem; 2019 Mar; 62(5):2738-2749. PubMed ID: 30741545
[TBL] [Abstract][Full Text] [Related]
10. Constitutive activity of neural melanocortin receptors.
Tao YX; Huang H; Wang ZQ; Yang F; Williams JN; Nikiforovich GV
Methods Enzymol; 2010; 484():267-79. PubMed ID: 21036237
[TBL] [Abstract][Full Text] [Related]
11. Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice.
Fleming KA; Ericson MD; Freeman KT; Adank DN; Lunzer MM; Wilber SL; Haskell-Luevano C
ACS Chem Neurosci; 2018 May; 9(5):1141-1151. PubMed ID: 29363944
[TBL] [Abstract][Full Text] [Related]
12. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice.
Kumar KG; Sutton GM; Dong JZ; Roubert P; Plas P; Halem HA; Culler MD; Yang H; Dixit VD; Butler AA
Peptides; 2009 Oct; 30(10):1892-900. PubMed ID: 19646498
[TBL] [Abstract][Full Text] [Related]
13. The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands.
Ericson MD; Freeman KT; LaVoi TM; Donow HM; Santos RG; Giulianotti MA; Pinilla C; Houghten RA; Haskell-Luevano C
Int J Mol Sci; 2023 Jun; 24(12):. PubMed ID: 37373293
[TBL] [Abstract][Full Text] [Related]
14. Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors.
Yang Z; Tao YX
Biochim Biophys Acta; 2016 Sep; 1862(9):1485-94. PubMed ID: 27208795
[TBL] [Abstract][Full Text] [Related]
15. Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.
Carotenuto A; Merlino F; Cai M; Brancaccio D; Yousif AM; Novellino E; Hruby VJ; Grieco P
J Med Chem; 2015 Dec; 58(24):9773-8. PubMed ID: 26599352
[TBL] [Abstract][Full Text] [Related]
16. Structure⁻Activity Relationships of the Tetrapeptide Ac-His-Arg-(
Schlasner KN; Ericson MD; Doering SR; Freeman KT; Weinrich M; Haskell-Luevano C
Molecules; 2019 Apr; 24(8):. PubMed ID: 31013889
[TBL] [Abstract][Full Text] [Related]
17. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.
Doering SR; Freeman K; Debevec G; Geer P; Santos RG; Lavoi TM; Giulianotti MA; Pinilla C; Appel JR; Houghten RA; Ericson MD; Haskell-Luevano C
J Med Chem; 2021 May; 64(9):5577-5592. PubMed ID: 33886285
[TBL] [Abstract][Full Text] [Related]
18. Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity.
Tao YX
Mol Cell Endocrinol; 2005 Jul; 239(1-2):1-14. PubMed ID: 15975705
[TBL] [Abstract][Full Text] [Related]
19. Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence.
Holder JR; Bauzo RM; Xiang Z; Scott J; Haskell-Luevano C
Bioorg Med Chem Lett; 2003 Dec; 13(24):4505-9. PubMed ID: 14643357
[TBL] [Abstract][Full Text] [Related]
20. Identification of novel GPCR partners of the central melanocortin signaling.
Li Y; Wang X; Lu L; Wang M; Zhai Y; Tai X; Dilimulati D; Lei X; Xu J; Zhang C; Fu Y; Qu S; Li Q; Zhang C
Mol Metab; 2021 Nov; 53():101317. PubMed ID: 34400348
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
