These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics. Datta-Mannan A; Thangaraju A; Leung D; Tang Y; Witcher DR; Lu J; Wroblewski VJ MAbs; 2015; 7(3):483-93. PubMed ID: 25695748 [TBL] [Abstract][Full Text] [Related]
4. SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity. Gonzales NR; Padlan EA; De Pascalis R; Schuck P; Schlom J; Kashmiri SV Mol Immunol; 2004 Jul; 41(9):863-72. PubMed ID: 15261458 [TBL] [Abstract][Full Text] [Related]
5. Engineering antibody heavy chain CDR3 to create a phage display Fab library rich in antibodies that bind charged carbohydrates. Schoonbroodt S; Steukers M; Viswanathan M; Frans N; Timmermans M; Wehnert A; Nguyen M; Ladner RC; Hoet RM J Immunol; 2008 Nov; 181(9):6213-21. PubMed ID: 18941211 [TBL] [Abstract][Full Text] [Related]
6. A two-in-one antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions. Lee CV; Koenig P; Fuh G MAbs; 2014; 6(3):622-7. PubMed ID: 24618680 [TBL] [Abstract][Full Text] [Related]
7. Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework. Hanf KJ; Arndt JW; Chen LL; Jarpe M; Boriack-Sjodin PA; Li Y; van Vlijmen HW; Pepinsky RB; Simon KJ; Lugovskoy A Methods; 2014 Jan; 65(1):68-76. PubMed ID: 23816785 [TBL] [Abstract][Full Text] [Related]
8. The structural basis of antibody-antigen recognition. Sela-Culang I; Kunik V; Ofran Y Front Immunol; 2013 Oct; 4():302. PubMed ID: 24115948 [TBL] [Abstract][Full Text] [Related]
9. Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions. Sidhu SS; Li B; Chen Y; Fellouse FA; Eigenbrot C; Fuh G J Mol Biol; 2004 Apr; 338(2):299-310. PubMed ID: 15066433 [TBL] [Abstract][Full Text] [Related]
10. Structural consensus among antibodies defines the antigen binding site. Kunik V; Peters B; Ofran Y PLoS Comput Biol; 2012; 8(2):e1002388. PubMed ID: 22383868 [TBL] [Abstract][Full Text] [Related]
11. Humanization of rabbit monoclonal antibodies via grafting combined Kabat/IMGT/Paratome complementarity-determining regions: Rationale and examples. Zhang YF; Ho M MAbs; 2017 Apr; 9(3):419-429. PubMed ID: 28165915 [TBL] [Abstract][Full Text] [Related]
12. Length of the antibody heavy chain complementarity determining region 3 as a specificity-determining factor. Barrios Y; Jirholt P; Ohlin M J Mol Recognit; 2004; 17(4):332-8. PubMed ID: 15227640 [TBL] [Abstract][Full Text] [Related]
13. Recombinant genetic libraries and human monoclonal antibodies. Adams JJ; Nelson B; Sidhu SS Methods Mol Biol; 2014; 1060():149-70. PubMed ID: 24037841 [TBL] [Abstract][Full Text] [Related]
14. SDR grafting--a new approach to antibody humanization. Kashmiri SV; De Pascalis R; Gonzales NR; Schlom J Methods; 2005 May; 36(1):25-34. PubMed ID: 15848072 [TBL] [Abstract][Full Text] [Related]
15. Antibody humanization by structure-based computational protein design. Choi Y; Hua C; Sentman CL; Ackerman ME; Bailey-Kellogg C MAbs; 2015; 7(6):1045-57. PubMed ID: 26252731 [TBL] [Abstract][Full Text] [Related]
18. Rational design of CXCR4 specific antibodies with elongated CDRs. Liu T; Liu Y; Wang Y; Hull M; Schultz PG; Wang F J Am Chem Soc; 2014 Jul; 136(30):10557-60. PubMed ID: 25041362 [TBL] [Abstract][Full Text] [Related]
19. Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. Nair DT; Singh K; Siddiqui Z; Nayak BP; Rao KV; Salunke DM J Immunol; 2002 Mar; 168(5):2371-82. PubMed ID: 11859128 [TBL] [Abstract][Full Text] [Related]