BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

127 related articles for article (PubMed ID: 26656811)

  • 1. Factors to Govern Soluble and Insoluble Aggregate-formation in Monoclonal Antibodies.
    Fukuda J; Iwura T; Yanagihara S; Kano K
    Anal Sci; 2015; 31(12):1233-40. PubMed ID: 26656811
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nonnative aggregation of an IgG1 antibody in acidic conditions, part 2: nucleation and growth kinetics with competing growth mechanisms.
    Brummitt RK; Nesta DP; Chang L; Kroetsch AM; Roberts CJ
    J Pharm Sci; 2011 Jun; 100(6):2104-19. PubMed ID: 21213307
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nonnative aggregation of an IgG1 antibody in acidic conditions: part 1. Unfolding, colloidal interactions, and formation of high-molecular-weight aggregates.
    Brummitt RK; Nesta DP; Chang L; Chase SF; Laue TM; Roberts CJ
    J Pharm Sci; 2011 Jun; 100(6):2087-103. PubMed ID: 21213308
    [TBL] [Abstract][Full Text] [Related]  

  • 4. High throughput formulation screening for global aggregation behaviors of three monoclonal antibodies.
    Li Y; Mach H; Blue JT
    J Pharm Sci; 2011 Jun; 100(6):2120-35. PubMed ID: 21491438
    [TBL] [Abstract][Full Text] [Related]  

  • 5. High Throughput Prediction Approach for Monoclonal Antibody Aggregation at High Concentration.
    Zidar M; Šušterič A; Ravnik M; Kuzman D
    Pharm Res; 2017 Sep; 34(9):1831-1839. PubMed ID: 28593474
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Examination of thermal unfolding and aggregation profiles of a series of developable therapeutic monoclonal antibodies.
    Brader ML; Estey T; Bai S; Alston RW; Lucas KK; Lantz S; Landsman P; Maloney KM
    Mol Pharm; 2015 Apr; 12(4):1005-17. PubMed ID: 25687223
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Kinetics of Monoclonal Antibody Aggregation from Dilute toward Concentrated Conditions.
    Nicoud L; Jagielski J; Pfister D; Lazzari S; Massant J; Lattuada M; Morbidelli M
    J Phys Chem B; 2016 Apr; 120(13):3267-80. PubMed ID: 27007829
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of Protein Conformation, Apparent Solubility, and Protein-Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1Monoclonal Antibody.
    Kalonia C; Toprani V; Toth R; Wahome N; Gabel I; Middaugh CR; Volkin DB
    J Phys Chem B; 2016 Jul; 120(29):7062-75. PubMed ID: 27380437
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based engineering of a monoclonal antibody for improved solubility.
    Wu SJ; Luo J; O'Neil KT; Kang J; Lacy ER; Canziani G; Baker A; Huang M; Tang QM; Raju TS; Jacobs SA; Teplyakov A; Gilliland GL; Feng Y
    Protein Eng Des Sel; 2010 Aug; 23(8):643-51. PubMed ID: 20543007
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Investigating the Degradation Behaviors of a Therapeutic Monoclonal Antibody Associated with pH and Buffer Species.
    Zheng S; Qiu D; Adams M; Li J; Mantri RV; Gandhi R
    AAPS PharmSciTech; 2017 Jan; 18(1):42-48. PubMed ID: 26340951
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies.
    Thakkar SV; Sahni N; Joshi SB; Kerwin BA; He F; Volkin DB; Middaugh CR
    Protein Sci; 2013 Oct; 22(10):1295-305. PubMed ID: 23893936
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Equilibrium studies of protein aggregates and homogeneous nucleation in protein formulation.
    Kiese S; Pappenberger A; Friess W; Mahler HC
    J Pharm Sci; 2010 Feb; 99(2):632-44. PubMed ID: 19548315
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effects of salts from the Hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an IgG1 monoclonal antibody.
    Majumdar R; Manikwar P; Hickey JM; Samra HS; Sathish HA; Bishop SM; Middaugh CR; Volkin DB; Weis DD
    Biochemistry; 2013 May; 52(19):3376-89. PubMed ID: 23594236
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody.
    Oyama H; Koga H; Tadokoro T; Maenaka K; Shiota A; Yokoyama M; Noda M; Torisu T; Uchiyama S
    J Pharm Sci; 2020 Jan; 109(1):308-315. PubMed ID: 31669120
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conformational and Colloidal Stabilities of Isolated Constant Domains of Human Immunoglobulin G and Their Impact on Antibody Aggregation under Acidic Conditions.
    Yageta S; Lauer TM; Trout BL; Honda S
    Mol Pharm; 2015 May; 12(5):1443-55. PubMed ID: 25871775
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A comparison of biophysical characterization techniques in predicting monoclonal antibody stability.
    Thiagarajan G; Semple A; James JK; Cheung JK; Shameem M
    MAbs; 2016; 8(6):1088-97. PubMed ID: 27210456
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effects of arginine on photostability and thermal stability of IgG1 monoclonal antibodies.
    Maity H; O'Dell C; Srivastava A; Goldstein J
    Curr Pharm Biotechnol; 2009 Dec; 10(8):761-6. PubMed ID: 19939215
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Product and process understanding to relate the effect of freezing method on glycation and aggregation of lyophilized monoclonal antibody formulations.
    Awotwe-Otoo D; Agarabi C; Read EK; Lute S; Brorson KA; Khan MA
    Int J Pharm; 2015 Jul; 490(1-2):341-50. PubMed ID: 25835267
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability.
    Goldberg DS; Bishop SM; Shah AU; Sathish HA
    J Pharm Sci; 2011 Apr; 100(4):1306-15. PubMed ID: 20960568
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aggregation of anti-streptavidin immunoglobulin gamma-1 involves Fab unfolding and competing growth pathways mediated by pH and salt concentration.
    Kim N; Remmele RL; Liu D; Razinkov VI; Fernandez EJ; Roberts CJ
    Biophys Chem; 2013 Feb; 172():26-36. PubMed ID: 23334430
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.